"Propranolol": analogues, tilmaamaha loo isticmaalo, sharaxaad iyo dib u eegis

"Propranolol" - daawo ka tirsan kooxda blockers la xushay. daroogada waxay leedahay saamayn antianginal, antiarrhythmic iyo hypotensive. medicament The maamulo ujeeddo ah daaweynta cudurada wadnaha ischaemic, thyrotoxicosis, hypertension. Daawada waa wax ku ool ah dystonia neuro, xanuunka dhanjafka. Waxa loo isticmaalaa in hirgelinta daaweynta wadnaha, kog. Daawada jidhka ka faa'iideysan in Wadnaxanuun myocardial. Waxay ula dhaqmaan arrhythmia iyo cardiomyopathy hypertrophic. Marka bukaanka ma ku haboon yahay dhigooda "Propranolol" waxaa loo arkaa a qorayaasha ku takhasusay in bukaanka waa fiicnayn.

Form sii daayo

Waxaad ka iibsan kartaa laba nooc oo ah daroogada - daroogada "Propranolol" iyo daroogada "Propranolol Nycomed". Tani waa daawooyin la mid ah in waxa soo saarey saarayaasha kala duwan ee kiniiniga.

Qaybaha daroogada

diyaarinta la sameeyey oo ku saleysan propranolol walaxda firfircoon. Qiyaasta qayb weyn ee laga yaabaa kala duwan - 10, 40, 80 iyo 160 mg in sidiisa oo kiniin kasta.

maaddooyinka darran loo isticmaalaa in soo saaridda ee kiniiniyada way kala duwan yihiin oo ay ku xiran tahay farsameeya. Si loo ogaado si sax ah waxa dawada ka hor inta la isticmaalayo waxaa lagama maarmaan ah in la akhriyo buuga.

Saamaynta daweynta ee daroogada

Bandhigay awood u leh inay xannibi receptors beta-adrenergic macnihiisu waa "Propranolol" diiwaanka. Analogues leeyihiin on jidhka ka mid ah in ay tallaabo ka. Kiniiniga saamayn on vascular derbiyada receptors beta 1 iyo 2. Saamaynta inhibitory on receptors kuwaas oo keenta in nasashada ee derbiyada vascular, oon baabi'inta badan oo dhibaatooyin ah - cadaadis dhiig oo sareeya, kordhay baahida wadnaha loo helo oxygen, sahayda saboolka ah ee nafaqo iyo oksijiin unugyada iyo xubnaha.

tallaabo Antiarrhythmic daroogada kor u muuqaalka kore ee isbedel wanaagsan ee jirka, sida caadi Guntin Dalqada wadnaha automaticity ah, hoos u tabinta Guntin atrioventricular, tirtirista excitability kordhay ee unugyada in ka kooban myocardium ah. Thanks to "Propranolol" soo celiyey hawlgalka caadiga ah ee wadnaha, ma jiraan wax cadaanyo ku meersan dibadda, kuwaas oo si xun u saamayn kara ay laxanka.

analogues "Propranolol" kor u qaado horumarka of saamaynta anti-anginal oo muujinayaa gobolka hagaagay ee muruqa wadnaha, yareynta qadarka oksijiin looga baahan yahay in ay hawlgalka. Taas macnaheedu waa in wadnaha waxay u baahan tahay ogsijiin yar in la dhimay, iyo inta jeer ee foosha, kuwaas oo sidoo kale waa la dhimay.

tallaabo Hypotensive ku salaysan yahay korodhka Lumen marinnada dhiigga iyo nasashada ee derbiyadooda. Codsiga of dhoos keli ah kiniin keenaysaa in la yareeyo cadaadiska dhiigga, saamaynta ay keentay waa la hadhay ugu yaraan 20 saacadood habeenkii. saamayn hypotensive deggan ayaa lagu arkay laba toddobaad isticmaalka joogtada ah ee kiniinka ka dib. Daawada ma ku haboon yahay gargaarka ee xaaladaha weheliyay kor u kac wayn ee cadaadiska, waxaa la tilmaamay for therapy waqtiga dheer ee hypertension.

isticmaalka daroogada muddada dheer keenaysaa in horumarka saamaynta cardioprotective. Muuji hoos u dhac in jaaniska ah ku xoogeystay of Wadnaxanuun myocardial ka dib markii therapy sida loola jeedaa dib u eegista "Propranolol", tilmaamaha. Si weyn u yareeyo khatarta dhimashada lama filaan ah ku dhaco. Waxaa la og yahay in daawadu ay leedahay saamayn togan ee cadaadiska intraocular kacsantahay.

Pharmacokinetics

Ka dib markii gudaha qayb jirka ugu weyn ee la nuugo daroogada (oo ku saabsan 90%), halka index ee bioavailability waa mid laga samri. Isgaarsiinta la borotiinada u dhiganta 93%. jidhka ka Drug laga saaro kaadida, kaas oo dhici metabolites. noocyada Constant ayaa in ka yar boqolkiiba hal daawo.

maragga

"Propranolol" edbinta analogues kuu ogolaanayaa inaad inuu ku meeleeyo daaweynta ee xaaladaha iyo cuduro gaar ah. Waxay loola dhaqmo hypertension portal iyo halbowlayaasha, Dystrophy myocardial, tayroodh. Daawada ka caawiyaa yareeyo xaalad ee Lumen cidhiidhi ah ee quseyo, gariirka lagama maarmaanka ah, weerarada argagaxa, waxaa loo isticmaali karaa sida qalab loogu isticmaalo prophylaxis ee xanuunka dhanjafka. Kiniiniga ku haboon daaweynta wadnaha ee askari ee, Wadnaxanuun myocardial, arrythmia. Daawada waxaa maamula in bukaanka qaba prolapse waalka mitral. By muujinaya waxaa ka mid ah tachycardia supraventricular iyo sanka. Howl hab sameeyo syndrome baxaan, kog, akathisia, oo sababo ay sabab u tahay isticmaalka neuroleptics. Daawada in bukaanka qaba pheochromocytoma for therapy isku dhafan. Daawada waxaa loo isticmaalaa in itaaldarrada dhaqdhaqaaqa shaqada ka dib dhalmo-dayska in la baabi'iyo daliilka ay negative.

sababo

Waxaa jira qaar ka mid ah sababo for "Propranolol" daroogada. Analogs la soo xulay kartaa in kiisaska daroogada ma ku haboon. Sababo ka mid ah:

• diid oo macnaheedu yahay qaybaha;
• lama filaan ah cardiogenic;
• bradycardia, inta lagu guda jiro taas oo tirada wadne halkii daqiiqo waa 55 sp.;
• aysiidh dheefshiidka,
• wadnaha chronic ama foomamka ba'an;
• rhinitt vasomotor;
• block sinoatrial, atrioventricular (2-dii, heerka 3aad);
• Prinzmetal angina ,
• cadaadiska dhiigga oo hooseeya;
• Isticmaal of insulin;
• syndrome Ulasocto sanka,
• Muddada ay joogaan inta lagu jiro taas oo soonka la joogo dheer;
• dhibaatooyin la xiriira wareegga durugsan (tallaabo decompensation);
• cudurka hanuun hore wareejiyay, taas oo saameyn ku marinnada hawada, neefta, helitaanka bronchospasm.

Waxa kale oo jira xaaladaha halkaas oo digniin loo baahan yahay. In arrimaha soo socda, waxaad dooran kartaa halkii daroogada analogues "Propranolol", micne ah:

• daweeyay gravis;
• diabetes (decompensated, subcompensation);
• kaafi muruqa wadnaha (asthma), beerka, kelyaha,
• ulcerös caydi,
• niyad-jabka,
• block atrioventricular (heerka kowaad),
• psoriasis,
• function kordhay qanjirka thyroid ka,
• Foomamka chronic ee boronkiitada,
• sonkorta dhiigga ee hooseeya,
• emphysema;
• da 'weyn;
• Inta aad uurka leedahay, naaska.

daaweynta daroogada

Bukaanka qaba dhiig-karka waa in la qaato qiyaasta daawada laba jeer maalintii of 40 mg halkii dose hal. Its korodhka suurto gal ah 14-28 maalmood gudahood. Haddii loo baahdo, kiniin cabbi karo maalin walba in qiyaasta 80 160 mg. Inta jeer oo ka mid ah hab la helo waa isku mid.

Markii bukaanada qaangaarka tachyarrhythmia cabbay saddex ama afar jeer maalin kasta laga bilaabo 10 ilaa 30 mg soo dhaweynta "propranolol" waxaa loola jeedaa. Analogs waxaa loo isticmaali karaa, haddii wax soo saarka this aan ku haboonayn. bukaanka ka yar qaba dhibaato la mid ah daroogada ay maamusho ee lacagta ah ee ka soo 0.2 si 0.4 mg halkii miisaanka jidhka kiilo. Inta jeer ee codsiga waxay ka dhigan tahay - sida saddex ama afar jeer maalintii.

Iyadoo tallaabo ka hortag ah in bukaanka loo aqoonsaday angina magacaabi afar qaadashada daawada maalin walba. Hal dose oo ah 20 mg. Its u kordhay waa suurto gal, waayo, intii toddoba maalmood ah. 40 mg ah ee daawada loo qaato heer la mid ah, 80 mg - wax yar ka yar inta badan (labo jeer).

Ka dib markii prophylaxis Wadnaxanuun myocardial loo baahan yahay. Orod waxaa medicament karaa "Propranolol". Size dose hal ku habboon yahay 40 mg, dhaweyntiisa daroogada ah maalin kasta waa in la maamulo saddex. Kordhiso qaadashada ilaa ugu badnaan 80 mg.

tallaabooyinka ka hortagga xanuunka dhanjafku waa in la buuxiyaa iyadoo la isticmaalayo 40 mg ah ee daawada laba jeer maalintii. Waxay u baahan yihiin in la kordhiyo qiyaasta 80 mg qaadashada daawada maalin kasta waxaa laga yaabaa in laba ama saddex, iyo carruurta - saddex ama afar. Xisaabinta qiyaasta dadka bukaanka yar la sameeyaa in tixgelinta miisaankooda, halkii kiilo of - ka 1.5 ilaa 2 mg.

Thyrotoxicosis - cudur ay daroogada la siiyo 10 mg laakiin aan ka badnayn 40 u helo saddex ama afar jeer maalintii.

Haddii aad qorsheyneysid inaad therapy pheochromocytoma, daroogada la weheliso blockers Alfa ah.

waxyeellooyin

Waa in aad bixiso waxa go'aaminaya dhibaatooyinka soo raaca daawooyinka "Propranolol" diiwaanka dareenka. Analogs dib u eegista - ma ahan xog yar oo muhiim ah, saamaynta doorashada ee daawooyinka loogu daweeyo. Si aad u halista ah ee dhibaato ee jirka waa ay yar tahay, waxaa lagama maarmaan ah in ay si taxadar leh u akhri tilmaamaha, waxaa waxtar leh in la ogyahay.

Daawada haddii loo isticmaalo si khaldan waxyeelayn kara nidaamka wadnaha sababa rabshooyin ee nidaamka dhexe ee habdhiska, habka hormoonada jidhka ah. daliilka negative suurto gal on qayb ka mid ah marinka dheef shiidka, rabshin laga yaabaa in xuubka iyo maqaarka. Waxaa ka mid ah dhibaatooyinka soo raaca ee ku qoran tilmaamaha - dhibaatooyin ka haysta neefsashada. Waxaa laga yaabaa in waxyeelo kale.

qiimaha Analogs

Ka hor inta iibsiga "Propranolol" analogues daroogada, qiimaha waxaa inta badan bartay bukaanka. Iibso kiniinka noqon kartaa 16-75 rubles. Price waxaa lagu go'aamiyaa tirada kaniiniyada halkii pack. Bedel daroogada wuxuu noqon karaa "Propranobene" medicaments "obzidan" ama "Inderal". Waxa kale oo aad ka dhigi kartaa daaweynta "Inderalom LA", "Inderalom".

By tixraacayo daroogada tilmaamaha "Propranolol" loo isticmaalo, qiimaha, analogs siiyaan macluumaad muhiim ah taas oo ka caawisa go'aan ugu fiican marka aad dooranayso daawooyinka iyo daawaynta.

Reviews

Rogaal inta badan wanaagsan. Waxay sheegay in daaweyn daroogada badanaa waa wax ku ool ah. Intaa waxaa dheer, dad badan oo ku qanacsan yihiin daawooyinka qiimo yar yahay. "Propranolol" maamula si ay u sii cadaadis dhiig oo heer caadi ah, si deg deg ah laga takhaluso wadno. Daawada yaraysaa astaamaha cudurka wadnaha, meesha dareen aadanaha. Faallooyin aan fiicanayn caadi ahaan waa dad ka tago sababta oo ah waxyeelo halis ah oo laga yaabaa inuu dhaco inta lagu jiro daaweynta. Mararka qaarkood waxaa jira tabar daran, dhibaatooyin hurdo, qarow.