Falanqaynta lagmamaarmaanna u ah dhiig. ALT iyo AST: waxqabadka kelmadaha

Aminotransferase, ama ALT iyo alanine aspartate, ama AST, waa ensaymes, kuwaas oo ku jira unugyada jirka, oo ay ku lug-shiid amino acid. Waxay ku taalaa waxa kaliya ee unugyada unugyo iyo dhiigga xubnaha galo unugyada dhacdaa oo keliya marka suuska ee dhaawacyo ama heley.

noocyada kala duwan ee cudurada

heerarka xad dhaafka ah ee ALT muujinaysaa horumarka heley xubnaha unugyada kaas oo ay jiraan waa tirada ugu badan. Waxaa jira sababo wixii badnaa ee ahaa aminotransferase cudurada beerka alanine. Raaxo iyo xanuun Rubuca saxda sare, shuban, xayd icteric oo ka mid ah maqaarka iyo xub-axaleedka, yaaqyaaqsi, lagu yarayn qadhaadh - kuwani waa calaamadaha kordhiyo ALT. In fulinta baaritaan dhiig si ALT oo kordhay iyo AST biiray heerarka bilirubin Qolol, halkaas oo ay jiraan horumarinta hepatitis. Inta badan siyaadiyaa ALT muujinaysaa ah ee cudurrada kale. fiirsashada ALT waa si toos ah ay ku xidhan tahay heerka uu cudurka darnaanta.

habka Necrotic ee muruqa wadnaha ee dhiigga oo dood la sii daayo ensaymes kuwaas. Siyaadiyay serum sidoo kale ku hadla ee ku saabsan horumarinta kardiopatology kale: failure, caabuq muruqa wadnaha. Dheeraad ah, sababaha kororka uruureen ALT serum joogo in dhaawacyada jirka kuwaas oo la xiriira dhaawac in unugyada muruqa, iyo ganaca wuxuu noqon karaa.

Falanqaynta lagmamaarmaanna u ah dhiig on ALT iyo AST ayaa tilmaamaya laga yaabaa in cudurka beerka, xameetida, wadnaha. Marka-fiirsashada AST kardioinfarkte kordhiyaa dhowr jeer, iyo ALT - yar.

Tilmaamayaasha waayo,

HAY'ADAHA jidhka bini'aadamka ku jira xaddi kala duwan ee falgalka ALT iyo AST, si sii kordhaysa fiirsashada of enzyme gaar ah waxay muujinaysaa a lesions xubin gaar ah:

• ALT waxaa inta badan ku yaala unugyada beerka, wadnaha, kelyaha iyo ganaca. In the case of burburinta ka mid ah meydadka in dhiiggiisa la sii daayay badan oo ALT. Markaas, si loo xaqiijiyo cudurka loo baahan yahay si ay u bartaan alanine ku aminotransferase.

• AST waxaa inta badan laga helo unugyada dareenka, muruqyada, beerka iyo wadnaha, iyo tiro yar oo unugyada ka mid ah unugyada ganaca, sambabada iyo kelyaha. Sidaa darteed, in daraasad dhacdo in this on alanine aspartate.

A ALT baaritaanka dhiigga iyo AST (transcript) waxay muujinaysaa xubnaha gobolka. Kordhi in ay caddayn xubnaha dhaawac jirka, taas oo ku yaalaan ensaymes kuwaas. Iyo, sida, hoos u caddayn bogsiiyey. korodhka A yar ee ALT in bilaha ugu horreeya ee uurka, waxaa la ogol yahay, laakiin waa in dib-u-baaro alanine dhiigga, si looga fogaado dhaawac beerka.

Lagmamaarmaanna falanqaynta dhiigga (tilmaamayaasha ee ALT, AST) waxa lagu qoray markii kardioinfarkt ee la tuhunsan yahay, iyagu waa calaamad hore ee cudur muhiimka ah. AST sharaxaad at falanqaynta lagmamaarmaanna u ka dhigayaa suurto gal ah in la ogaado oo la socdaan isbeddello kale ee dhaqdhaqaaqa muruqyada wadnaha, cudurada beerka iyo cudurrada muruqyada striated.

Diyaarinta si ay dhiig u ururinta waxbarasho ee

Dhiig for falanqaynta Kiimikada noole waxa laga soo qaatay xididka aroortii calool madhan. Waqtiga falanqaynta tegayo 8:00. isticmaalka ee la soo dhaafay of cunto ah. 24 saac. si sampling dhiigga waxaa ka mamnuuc ah isticmaalka khamriga iyo shiilay iyo cuntooyinka dufanka leh. Waxaa lagu talinayaa in la yareeyo fiznagruzki. Isla markii ultrasound ah, X-ray, waxbarasho fluorography, colonoscopy ama dhiig daaweynta dabiiciga ah laguma talinayo in ay doortaan, waayo, falanqaynta, haddii kale waxaa lagu margado doonaa Kiimikada noole qoraalka. Wixii 1-2 toddobaad. waxbarashada lagmamaarmaanna u baahan tahay in aad joojisid qaadashada dawada. Marka ay tahay wax aan macquul aheyn in ay la kulmaan xaalad this, jihada ladan dhakhtar for falanqaynta, note on dhaweynta ah ee daroogada iyo qiyaasta. On the lagmamaarmaanna falanqaynta dhiigga (qoraalka ALT, AST) saamayn kara fiznagruzki culus, iyo sidoo kale isticmaalka khamriga iyo hemolysis haysta.

Deciphering baaritaanka dhiigga - ALT, AST: caadi

Maxaa tiro ka mid ah ensaymes kuwaas waa in lagu hayaa dhiig caafimaad aadanaha? Barbaro chemistry dhiigga (transcript ALT, AST), heerka loogu tala galay dumarka - laga bilaabo 31 ilaa 35 halbeeg halkii litir oo dhiig ah. Si aad galmo xoog, tiradaasi waa wax yar oo kala duwan. ALT Normal in dhiiggii nimankan (Kiimikada noole kelmadaha) - laga bilaabo 41 ilaa 50 U / L. In dhallaanka (illaa 1 bil.) U dhiganta reading caadiga ah ee 75 cutub, 2 ilaa 12 bilood. - wax ka badan 60 halbeeg, iyo hal sano iyo ilaa 14 sano - in ka yar 45 cutub. Falanqaynta Dhiig (kelmadaha ALT, AST) oo leh calaamad muujinaysa sare waxay muujin kartaa dhaawac cirrhotic ama ba'an caabuq ku dhaca beerka, joonis gabsiiya ama hemolytic, cudur kale ee beerka (iyo neoplasms r. H), angina-yada qalalka, carditis, myopathy, Stasis bile rheumatic ba'an , cudurka thromboembolic lungemboli iyo pankreatit ba'an. imtixaanka ALT iyo AST dhiigga (kelmadaha) la sii kordhaya muujinaya arkay dhaawacyo, qalliinka wadnaha ama angiokardiografii. La kordhiyo heerka AST 20-50 jeer xaaladaha qaarkood, caddaynta cudurka beerka, Ulasocto galleeyda, hepatitis iyo etiology viral. Heerarka sare ee AST 2-5 jeer ka hadli karaa cudurro hemolysis, dhaawacyada muruqa, pankreatit ba'an iyo gangrene. Marka ifafaale side ee muruqyada iyo dermatomyositis arkay koror 8-laab ACT.

Wehliyaha Rytis

Si aad u hesho falanqayn sax ah oo ka mid ah jawaabaha ee ALT dhiigga iyo AST (kelmadaha) muujinaysaa transferases tilmaamayaasha xiriirka. la xiriirta Tani waxay muujinaysaa Wehliyaha de Ritis sameeyay mid ka mid serum waxbarasho. Haddii tirada kor ku xusan iska caadi ah (N = 1,3), waxay muujinaysaa joogitaanka kardioinfarkta, iyo marka ay tahay hoos ku tilmaamayaasha caadiga ah - on hepatitis viral.

Tan iyo aminotransferases leedahay deegaamaynta unugyada, falanqaynta dhiigga muujiso cudurada myocardial AST kelmadaha iyo ALT - cudurada beerka, i.e. joogitaanka burburka gacanta:

• Marka ay jirto xad dhaaf ah 2 jeer ama ka badan, ee qalbigiisu go'aaminta wadno.

• A ALT baaritaanka dhiigga iyo AST (transcript) tusay xad-dhaaf ah oo la taaban karo - waa caddayn of hepatitis faafa ee Xilliga cudurku ku.

• By yareynta tilmaamayaasha alanine - la'aanta jidhka ee pyridoxine. Waxaa u baahan tahay uurka difdiagnostiki.

xeeladaha

Sida caadiga ah, ee serum transferase jira qiyaasta yaryar. Dhamaan doorashooyinka si loo hagaajiyo alanine jidka khasab mari baaritaanka.

Si ay u bilaabaan falanqaynta labaad lagmamaarmaanna u ah dhiig (qoraalka ALT, AST) waa in la qabtaa. Dib-u-baadhista ee qaar ka mid ah shakhsiga (deeq) oo ku saabsan mid ka mid ah saddex-meelood meel ka mid ah xaaladaha muujinaya heerarka caadiga ah.

Next aad u baahan tahay in si taxadar leh u soo ururin taariikhda iyo samayn baaritaan buuxa.

Doorka taariikhda fulinta decryption ah

taariikhda ee la soo dhaafay waxaa ka mid ah warbixin ku saabsan soo dhoweynta ee daawooyinka, dhiig lagu shubo, joogitaanka joonis ama hepatitis syndrome, cudurada qoys beerka ama joogitaanka habka cirrhotic in iyada calool xanuun, kansarka, sonkorowga, cayilka ama, taa ka duwan, si degdeg ah miisaanka oo yaraada.

cudurka beerka Qoyska - waa ku tiirsanaanta khamriga, cudurka Wilson ee , iyo kuwa kale.

Haddii ALT iyo baaritaan dhiig AST (transcript) tusay kor qiimaha caadiga ah ee ka yar laba jeer, waxaa lagama maarmaan ah inuu abaabulo ilaalinta iyo kormeerka of 2-laab. xeelad Tani waa fiicnayn dadka bukaanka ah.

A ALT baaritaanka dhiigga iyo AST - qoraalka ee cudurada qaar ka mid ah

Kororka yar ee transferases la egyahay muujinaysaa nonalcoholic nooca dhaawac beerka, oo ay ku jiraan "beerka dufanka leh", steatogepatoz nonalcoholic, hepatitis viral qaab raaga.

korodhka Dhexdhexaad jira in viral ama khamriga bararka beerka iyo cudur beerka ku gaamuuray kala duwan leh ama aan lahayn waxaa dhaawac cirrhotic.

Heerarka sare ee caadiga ah ee hepatitis ba'an, sun ama daroogada galleeyda, lama filaan ah ama ischemia cagaarshowga.

Baahnayn in heerar sare (ka weyn yahay 2,000-3,000 U / L) lagaga overdosing acetaminophen iyo adeegsadaan in bukaanka khamriga ku tiirsan in si lama filaan ah iyo / ama ischemia cagaarshowga.

Waa in la ogaadaa, tan iyo ALT waa in unugyada dhiigga cas, lagama maarmaan ah si looga hortago burburkii diyaarinta serum for falanqaynta. ALT laga yaabaa in la naaquso marka lagu kaydiyaa serum dhowr maalmood.

Doorka qalab caafimaad, iyo geedo yaryar iyo waxyaabaha kale ee

Taxaddar qaadashada taariikhda iyo shaybaarka kelmadaha natiijada ay muhiim u yihiin garashada transferases kordhay-laaluusheen daroogada. dhaawaca beerka la mid ah la ogaado in 1-2% ee kiisaska barar chronic qaab beerka. Waxay waxaa la xidhiidha qaadashada antibiotics, antiepileptics, inhibitors ee inhibitors reductase hydroxymethylglutaryl-CoA, daawooyinka anti-bararka magnyl iyo medicaments oo lagu daweeyo qaaxada.

Habka ugu fudud si loo ogaado tiirsanaanta ee kororka of aminotransferases oo leh awood wax kasta - si ay u joojin, iyo inay dhawrayaan heerka eulayska. baajinta No loola jeedaa xiriirka this aan la go'aamin karaa.