"Ursofalk": analogues, tilmaamaha loo isticmaalo iyo foomka sii daayo

Medicament "Ursofalk" diiwaanka tilmaamaysaa sida daroogada la qaybaha kala duwan ee hawlaha, taas oo uu leeyahay, iyo kuwo kale, hepatoprotective, cholelitolitic, guryaha immunomodulatory. Sidoo kale, daroogada si weyn u yaraynaysaa heerka kolestaroolka dhiiggaaga.

wax firfircoon

Walaxda firfircoon ee medicament ku dhaqmo ursodeoxycholic acid. Oo waa hadiyad in lacagta qaar ka mid ah in bile aadanaha, laakiin iyadoo ay sabab u cudurada qaarkood shaqeeya Avv beerka iyo sida, content oo ah walaxda in bile waa la dhimi karaa.

acid Ursodeoxycholic sida qayb weyn joogo ma aha oo kaliya in diyaarinta "Ursofalk". Analogs of Halabuurka iyo pharmacological guryaha - kuwan daroogada sida "Ursosan", "Ursol", "Urdoksa". La hadal dheeraad ah oo ku saabsan hoos.

saamaynta daweynta "Ursofalk" hab

• saamayn Choleretic waa hoos u dhac ku yimid qaddarka lacagta ee acids bile hydrophobic iyo kor u sii daayo ee Lumen xiidmaha. Intaa waxaa dheer, daroogada ay sabab u tahay in ay xidhiidhka la axalaha hoos receptors nuugista acids sun hydrophobic.
• tallaabo Immunomodulating waxaa keena xaqiiqda ah in ursodeoxycholic acid waa awood yaraynta hadalka ee u taagoo HLA hepatocytes fasalka ugu horeysay, iyo cholangiocytes - taagoo HLA fasalka labaad. Sidoo kale daawo yaraynaysaa ereygu wuxuu ahaa ee cytokines pro-bararka.
• Saamaynta cytoprotective waa awooda oo ka mid ah walxaha firfircoon si ay u dhex gasho galay lakabka la egyahay xuubka unug ka, taasoo keentay in xuub gacanta degto hantida ilaalinta waxaa hagaagay.
• saamayn Hypercholesterolemic ku salaysan yahay dhimista ee axalaha soo nuugista iyo hoos u dhac Avv kolestaroolka beerka, iyo sidoo kale ay Digo ee bile ah.

Ka sokow saameynta kor ku xusan, "Ursofalk" daroogada (tilmaamaha loo isticmaalo daliil) foomamka crystal dareere la Britain ee kolestaroolka yareeya bile lithogenicity ah. Sababo la xiriira diinta ee xeryahooda kolestaroolka hoos u formation of dhagaxyo waa fasakha.

Pharmacokinetics

Ka dib markii maamulka afka daroogada ee xiidmaha yar nuugo ursodeoxycholic acid, nuugo waxaa ku badan gaadiidka firfircoon axalaha ee qaybta terminal, iyo gaadiidka dadban - ee jejunum iyo axalaha ee qaybta sare. Qiyaastii 60-80 boqolkiiba qiyaasta helo dhiiga.

walaxda firfircoon waxaa dheefshiida beerka iyo qayb disintegrates ku jira xiidmaha, taas oo horseedaysa formation of sun toddoba-Keto acid lithocholic, taas oo, markeeda, waxaa nuugo dhiiga iyo ilaa xad yar oo ka saara beerka. Half-nolosha ee daroogada - saddex - shan maalmood. Waxaa inta badan raaca saxarada sida metabolites.

Tilmaamayaasha loo isticmaalo

Diyaarinta "Ursofalk" qaab diiwaanka loo isticmaalaa in cudurada of xameetida, beerka, Ulasocto kordhiyo kolestaroolka dhiiggaaga, cholestasis, beerka hawlaha hoos u gaar ah. Ka mid ah xanuunnada sida la xusay waxaa laga yaabaa in cirrhosis biliary (hoose), gastritis reflux biliary, cholangitis sclerosing (hoose), esophagitis reflux biliary, hepatitis of etiology kala duwan, cystic fibrosis.

Daawada waxaa loogu joogitaanka soosaaray, laakiin waa haddii ay rentgennegativnye dhexroor, oo ay size kama badna shan iyo toban milimitir, iyo bukaanka ma carqaladeeyo hawlaha khalkhalka ah. medicament waxaa sidoo kale loo isticmaalaa in ay dhacdo sumoobo beerka (tus, sumowga khamriga), ay cudurada Ulasocto cholestasis (carruurta), Tardive biliary, atresia ee laga shido bile intrahepatic. bukaanada ka qaaddid oo uu on nafaqada parenteral, si ay u tirtiraan fadhiidka ah ee bile, iyo sidoo kale dadka qaatay qaliin beerka.

Sida wakiilka profilatikada a maamula daroogada "Ursofalk" (analogs daroogada ayaa sidoo kale waxaa loo isticmaali karaa in kiisaskan) isku mar la soo dhaweynta ah ee daroogada taas oo si xun u saameyn kara hawlaha beerka (uurka hormoonnada ah, daroogada iyo saamayn cholestatic).

foomka Release iyo halabuurka

Laba foomamka sii daayo daroogada uu leeyahay "Ursofalk": ganaax (analogues no, soo saaray Switzerland) iyo kaabsoosha (analogs waxaa la soo saaray ee Germany). version hore ee daroogada waxaa inta badan loo isticmaalaa carruurta ama dadka leh wax liqidda oo dhib ah. kaabsoosha gelatin yihiin Doolaal, adag, cover iyo jidhkaaguba rinji cad, gudaha - dhagaxyada ah caddaan ama budo. Available in baakado 10, 25, 50 ama 100 oo gogo '. Hakinta ayaa sidoo kale waxay leedahay midab cad, lagu gartaa joogta ah oo dhqaalaha, ka kooban goobooyin hawo ah, waxa ay leedahay caraf liin ah. Available in sibraar oo 250 millilitir, complete lifaaqan qiyaaso qaaddo.

250 mg ah ursodeoxycholic acid waxaa ku jira diyaarinta kaabsal, tiro la mid ah oo ah walaxda firfircoon joogo shan millilitir (mid qaadada) slurry "Ursofalk" a. sharoobada wuxuu ka kooban yahay qaybaha kaabayaal: glycerol, acid ammooniya qaarna, xylitol, tones propylene, chloride sodium, cellulose mikrokristallin, Benzosyrene acid, dhadhan liin, sitraydh sodium, biyo la safeeyey, sodium cyclamate. maaddooyinka Sare ee kaabsoosha bandhigay Kolloidol dioxide Silicon, titanium dioxide, sodium lauryl sulfate, galleyda, milmahayn magnesium, gelatin, biyo sifaysan.

Sida loo qaato "Ursofalk"

medicament The in ay dhacdo meel dhaweynta hal dooni inaad hesho fiidkii. Kaabsol waxaa liqday, aan qaadka, iyo hoos u maydhay biyo in tirada saxda ah. Sida horeba loo xusay, "Ursofalk" daawo loogu talagalay carruurta waa fiican in la isticmaalo qaab ganaax ah (syrup). qiyaasta waa in la xisaabiyaa dhakhtar, ku salaysan nooca cudurka iyo astaamaha jirka bukaanka. Dhallaanka (oo leh miisaan ah shan kiilo) waa in la siiyaa at quarter hurdada slurry qaaddo qiyaaseed.

Sida caadiga ah, waayo, beerka dose maalin ee dadka waaweyn waa 10-15 mg halkii miisaanka jidhka kiilo, koorsada of therapy socdaa lix bilood ilaa laba sano, laguma talinayo in ay taasi dhacdo nasashada ee medicament soo dhaweynta. Waayo, dadka qaba esophagitis reflux biliary ama gastritis reflux biliary maalin dose "Ursofalk" daroogada - daaweynta 250 mg - toban - afar iyo toban maalmood. Marka cholangitis sclerosing iyo cirrhosis biliary maalin kasta, sida caadiga ah kuu qori qaadato 10-15 mg halkii miisaanka jidhka kiilo, laakiin haddii loo baahdo, ee qiyaasta kordhay ilaa 20 mg 1 kg. Therapy inta badan socdaa lix bilood ilaa laba sannadood. Bukaanka qaba cystic fibrosis daawada maalin kasta qaadan at dose oo ah 20-30 mg halkii kiilo ee miisaanka jidhka ka badan lix bilood ilaa laba sannadood. In the case of sumoobo beerka lagu muujiyay si ay u fuliyaan daroogada at dose maalinle ah oo 10-15 mg halkii kiilo ee miisaanka jidhka muddo lix - laba iyo toban bilood.

"Ursofalk" daawo. analogs

Dabeecadaha la barbardhigo daawooyinka daawooyin la mid ah in Halabuurka iyo guryaha pharmacological.

• Drug "Ursosan". Alaabta Tani waxaa la macmalay ee Jamhuuriyadda Czech iyo Germany, waa la heli karaa oo kaliya ee foomka of kaabsulka. hab ay of tallaabo ee daawooyinka la mid ah. Si kastaba ha ahaatee, daaweynta, hepatologists, dhakhaatiirta cudurada faafa on su'aasha ah oo daroogada waa ka sii wanaagsan, "Ursosan" ama "Ursofalk" si wadajir ah uga jawaabaan in ay tahay ka fiican in la doorto labaad. gunaanad noocan oo kale ah ayaa la sameeyey by khubaro ku saleysan indhaynta caafimaad oo iyaga u gaar ah oo ra'yi ka bukaanka. Daawo "Ursofalk" waxaa loo wareejiyey badan ka sahlan analog loo arkaa, waxa ay sidoo kale normalizes doonaa gobolka functional of beerka. Laakiin ha iloobin oo ku saabsan sifooyinka gaarka ah ee u shaqeeyo, waxaa jira dad ka dhigan tahay "Ursosan" caawisaa wanaagsan. Intaa waxaa dheer, daroogada waa qiimo yar yahay xoogaa ka jaban, pack 50 kaabsulka ku kici doonto 650-830 rubles, halka 50 kaabsoosha daawada "Ursofalk" bixin doontaa 850-1200 rubles.
• macnihiisu yahay "Urdoksa". Daawada generic la soo saaray gudaha. Si kastaba ha ahaatee, soo saara shirkad ah dawooyinka si aad u iibsato waxyaabaha lagama maarmaanka ah ee dibadda, iyo in Russia waxaa jira oo kaliya habka wax soo saarka daroogada. Waxaa sidoo kale laga heli karaa kaabsoosha, qiimaha 50 gogo 'kala duwan 440-960 rubles. Labada daroogada la mid, in saamayn farqiga weyn ka soo saaray aan arkay waa.
• "Ursol" daawo. Medicine, sida in kiiska la soo dhaafay, waxaa la sameeyey ee Russia. Si kastaba ha ahaatee, dad badan ayaa sheegaya in dhammaan lacagaha waa dhagaxyo u kala diray waxaa u roon in xameetida. Laakiin waxaa jira kuwa waxtarka daawaynta ahaa sare marka la qaadanayo daawada "Ursofalk". kaabsoosha waxay leeyihiin qaab la mid ah, si siiyaan doorashada si hal ama doorasho kale waa ay adag tahay. Haddii aad diiradda saaraan qiimaha, waxa fiican in ay u soo iibsadaan daawada "Ursol" waa ka raqiisan - 460-905 rubles 50 kaabsulka.

waxyeellooyin

medicament "Ursofalk" Pretty si fiican loo dulqaatay by bukaanka. daroogada Analogs sidoo kale lagu gartaa tolerability wanaagsan. Mararka qaar, inta lagu guda jiro daawaynta jiro kalshum soosaaray horumarinta saxaro fudud, xanuun gaastari ah. Intaa waxaa dheer, waxaad laga yaabaa in xasaasiyad qaab pruritus, urtikaria. Wararka qiyaasta xad dhaafka ayaa la soo sheegay in ay taariikhda.

sababo

dareen High gaarka ah si ay qaybaha daroogada waa aasaas u ah diidmada isticmaalka. Daawada waa u siiyo dadka qaba cholangitis, ama qabsamin of koollo u bile fibrosis, cholecystitis ba'an. Ha kuu qori daroogada si uu bukaanka ka cabanaya xadgudub ku ah shaqo motor of kaadi haysta, calool bile ah.

Uurka iyo nuujinta

Sida laga soo xigtay waxbarashada, ursodeoxycholic acid ma muujiyaan mutagenic, teratogenic, hawl embryotoxic, laakiin ay awoodda si ay u dhexgalaan kala ooday gematoplatsentarny iyo saamayn koorsada ee uurka aan la bartay ilaa dhamaadka. Sidaa darteed, qaado daawada "Ursofalk" inta lagu guda jiro iyo wallacaaga oo keliya marka ay muhiim noqoto dhakhtar soo qoray. Khibrad isticmaalka daawada muddada nuujinta ee aan la heli karin.

Isdhexgalka daawooyin kale

daaweynta wadajira diyaarinta ka kooban hydroxide aluminium ashito, iyo daawada "Colestipol" iyo "Cholestyramine" keenaysaa in hoos u nuugista systemic oo ah walaxda firfircoon. Daawada bedali kara fiirsashada ee plasma dhiig daroogada "takrolimus". Haddii ay jirto baahi loo qabo isticmaalka wadajirka ah ee daawooyinka sida waa in la qaato dura ugu yaraan laba saacadood.