"Alfa Epoetin": diiwaanka, dib u eegista iyo analogues

heerka Uncharacteristic fiirsashada of hemoglobin - mid ka mid ah calaamadaha anemia. Dhab ahaantii, tani ma aha cudurka, laakiin kaliya calaamad in uu yahay astaanta of cuduro badan oo. horukaca cudurka sida astaan u noqon kartaa nabar hoose ee nidaamka dhiigga.

saameeyaan of erythropoiesis, oo loo yaqaan magaca caalamiga ah non-lahaansho sida tilmaamaha "Epoetin Alfa" loo isticmaalo sida reagent qabto waxqabadka sare ah guryaha pharmacological waxaa lagu hagaa inay ku daaweynta iyo ka hortaga dhiigyaraanta of etiologies kala duwan. qiyaasta habboon u doortay waxaa ka caawisaa ma aha oo kaliya xasiloonida dhismeedka qayb dhiig, laakiin sidoo kale waxa uu leeyahay saamayn togan ku muruqa wadnaha.

foomka Release iyo Halabuurka kiimikada

Shayga, daawooyinka waxaa laga heli karaa farmasiyada qaab:

• saliingaha la tuuro oo Nadiif ah la qiyaas horena (design siinayaa cirbadaha ilaalinta oo dheeraad ah);
• Xalka in fijaan.

Doorka qayb kaabayaal ah waxaa la siiyaa:

• biyo la isku duro,
• dihydrate chloride iyo hydrogenphosphate sodium,
• polysorbate-80.

Waxqabadka noolaha oo ah walaxda in dhalada noqon kartaa kala duwan. Xaaladaha intooda badan, kun ama laba kun Units International per ml 0.5 ee dareeraha ah. Si kastaba ha ahaatee, waxaa jira sidoo kale iibinta foomamka reagent kale, oo ay ku jiraan "epoetin Alfa" 10,000 kumbiyuutarada. / 1 ml.

hab ay of tallaabo pharmacological

guryaha Biological iyo difaaca ee alaabta ku dhexsameeysmo jirka waa inay isku erythropoietin dabiiciga ah. Sidaa darteed, daawooyinka aad u wax ku ool ah lagu cabudhibayo calaamadaha anemia, oo hagaajiya dhiigga sida glycoprotein caadiga ah. waa waxaan idinku leeyahay, "Alfa epoetin" ugu horrayn looga dan leeyahay sii kordhaya hiimotokiriit iyo heerka hemoglobin caadi. Uu "shaqo wadnaha," iyo sidoo kale u janjeera ka mid ah qaybaha uu u wanaajiyo socodka dhiigga unugyada waa yar fahmayaan.

bar-time:

• duro xididka - afar saacadood
• marka subcutant duray - oo ku saabsan maalinta a.

fiirsashada ugu badan ee reactant ah ee plasma in la filayo 12-18 saacadood ka dib.

Gudigga pharmacokinetic

Daraasado ayaa muujiyey in daroogada tilmaamay xaadiriyaan formation of antibodies ee hab "nasinta", iyo muhiimadda ay leedahay pharmacological in geedi socodkii fibrosis dhuuxa lafaha ku dhow yahay inuu eber. The protein jajab medicament "Epoetin Alfa" ka kooban oo ku saabsan 165 acids amino (58% wadarta miisaanka ku kelli), kanna waa ka muuqataa in ay degree iyo tayada qaybaha ay saameyn ku qeybinta / kaladuwan ee unugyada progenitor.

Soo noqnoqda maamulka xididka (in maqnaanshaha heley kelyaha) noqonin mid horseeda in raasamaal oo ah walaxda firfircoon; caruurta da'doodu ka yar tahay 12 sano waa Dheereyn badan tahay ee T1 / 2 muddo ilaa 6 saacadood.

Tilmaamayaasha waayo,

"Alfa Epoetin" waxaa lagu talinayaa in la isticmaalo haddii:

• anemia cudurka sida disorder ah function hematopoietic, taas oo uu weheliyo kansarka (dhacaan in ay burooyin aan myeloid);
• bukaanku uu baahida loo qabo in si joogto ah kelyaha ama saarista xuubka hoose ,
• waa su'aal ah fulinta qalliinka adag iyadoo la isticmaalayo in dhiig lagu shubo allogeneic;
• bukaanka cudurka HIV iyo helidda daaweynta ku salaysan zidovudin;
• Goolasha u baahan tahay ka hortagga.

The mudada kacmaha fiicnayn

Wixii diyaarinta "Alfa Epoetin", caanaha ee xulista shakhsiga ah ee qiyaasta maalinlaha ah. Si kastaba ha ahaatee, talooyinka guud ee soo saaraha ku eg tahay xeerarka sida iyo heerka:

• at edbinta bilowday wajigii konton unugyada ficil (IU) halkii miisaanka jidhka kiilo, laakiin aan ka badnayn saddex irbado / infusions wiigii;
• ay ka maqan yihiin shaqada la arki karo: 75 halbeeg / kg at bareeg ka mid ah, laakiin aan ka horeyn ka badan hal bil ka dib markii bilow daawaynta,
• in xaaladda gaarka ah: 100-200 U / kg, si adag u hoggaansanaayeen sheegay in jadwalka isku duro (tallaabo kordhay - 25 halbeeg / bishii);
• therapy dayactirka: dose maamula at heerka ahayd oo kala duwan hiimotokiriit of 30-35 vol ah. %.

Sida dhaqanka shows, ee heerka "standard" caadi ahaan la qaataa hal of 30-100 IU / kg, kaas oo sida caadiga ah la wado dhamaadka dialysis. Muddada aan fiicnayn i of / v galiyey - hal ilaa laba daqiiqo, hab loo gaarsiiyo subcutaneous oo ka mid ah walxaha firfircoon raacaan isla xeerasha.

Qoondaynta oo ah saamaynta gurracan ee suurogalka

On dareen-celin xaaladood shaqeeyo atypical ee joogitaanka qaybaha daroogada "Epoetin Alfa" diiwaanka ayaa sheegay in soo socda:

• suurto gal ah in arki calaamadaha u gaarka ah fayraska hargabku - wareer aad u daran, murugada, daciifnimo, qandho, daran xanuun wadajir / murqaha;
• ogol yahay ee isu dheelitir la'aanta ka mid ah halbowlayaasha wadnaha iyo dhiig - kor u kac wayn ee cadaadiska dhiigga, dhiig-karka malignant,
• mid ka mid is illowsiin kartaa halista thrombocytosis (cudurka, inkastoo ay saamayn waa mid aad u dhif ah, laakiin waa ben la dhibaatooyin daran);
• reagent in nidaamka kaadida waa inay awoodaan inay saamayn by beddelo xaddiga potassium iyo phosphate ee jirka (heerarka kariyaatiniin ma eryey kordhiyo plasma dhiig).

On maqaarka sidoo kale waa cuncun mararka qaarkood dareemi huriyay hordhaca ah ee "Alfa Epoetin" diyaarinta. Tilmaamaha, gaar ahaan, ku hadla ee finanka, cambaarta, anjioedema. Oo waxa xiiso leh: marka subcutaneous duro darnaanta boqolkiiba waa badan: celcelis kun kiisaska, xisaabiyenimo ah oo ku saabsan 4 dhacdooyin (with on / in infusions - 1.6 keliya).

On isbedel difaaca jirka ee keeni lahaa ayaa sheegay in walax, ma macluumaad lagu kalsoonaan karo (xusid mudan marka laga reebo in awoodda hore u soo sheegnay ee daroogada si uu u abaari formation of antibodies).

Sida laga soo xigtay sababo saaraha

Iyada oo ku saleysan macluumaadka lagu siiyey in guide rasmiga ah, "Epoetin Alfa" (analogs sida "Binokrit" iyo "Eralfon" saaraysa sida ugu dhow in asalka ah) waa in aan la isticmaalaa haddii:

• cudurka hypertension caasiyoobay,
• bukaanka ku dhacdaa diidmo in Cuntadan;
• Falanqaynta hordhaca tusay a khadadka dhiig heley muhiim ah;
• bukaanka wadna xanuun (waxaan ka hadleynaa ee la soo dhaafay dhawaan) ah;
• ay jirto sabab lagu rumaysan in carqalad ah ee socodka dhiigga caadiga ah ee maskaxda ku jira.

In si kale loo dhigo, bilowga daaweynta waa in uu ka muuqadaa baaritaan caafimaad.

ganaaxyada

"Alfa Epoetin" (tradename qaab samaynta isku kala duwanaan karaan - tusaale ahaan, sida bedelkiisa loo soo bandhigi karaa analogs "Aeprin", "Repoetin-SP", "Epokomb", "Eprex", iwm ...) Waa in la isticmaalo iyadoo kordhay digniin ka dhan ah dadka ka cabanaya xanuunada / noq chronic ee muruqyada durugsan. Xeerkani waa run gaar ahaan haddii taariikh sida jawaab oo jidhka ah in qaadashada daawooyinka qaarkood hore u diiwaan dhacdooyin of falcelinta convulsive.

Waxa aanu faragelin feejignaan iyo turqo. Lahjadda ugu horeysay u baahan tahay in meel arrimo la xiriira cadaadis dhiig oo dhacdo ee madax xanuun (antihypertensives - mid ka mid ah kuwan soo socda kaabidda Dabcan caafimaad). Si kastaba ha ahaatee, waxaa sidoo kale muhiim ah in la qiimeeyo oo gobolka dhabta ah ee dukaamada bir ah (ka hor irbado joogto ah). Marka u gudanno howlaha ku filan kama muuqato marka la eego cadaadiska dhiigga, farsamo ku tilmaamay wax soo saarka pharmacological la joojiyo.

Waa in aan xasuusnaano in kelyaha, kansarka iyo HIV ku jira liiska cudurrada ee koorsada of taas oo, ka dhanka ah asalka ah fiirsashada hiimotokiriit ah, waxaa jira hoos u dhac caan heerka birta ee plasma dhiigga. Si loo yareeyo isu dheelitir la'aanta miciinka in daaweyn beddelaad ah oo ku lug leh reactants Fe-ka kooban.

Baarka hemoglobin waxaa lagu talinayaa in ay qaataan 1 time 7 maalmood oo kasta. Sidoo kale intii lagu jiray olole caalami ah oo laba bilood ah ayaa loo baahan yahay la socodka joogtada ah ee dhiig xinjirowga. Oo 5-10 maalmood ka hor qaliinka, bukaan waxaa maamula walxaha card daawo isagoo guryaha antithrombotic.

saaraha isagu meesha kama saarayo in qaybaha daroogada saamayn ku yeelan kartaa noocyo ka mid ah burooyinka, si daawashada bukaanka waa in aan la joojiyay tan iyo dhammaadka wejiga firfircoon ee daaweynta.

Waxa la sameeyo haddii ay dhacdo of badinta?

"Alfa Epoetin" (micne-daroogo, kadis ah, fal hab la mid ah) oo la badinta u dhaqmo sida algorithms ka daray in formula kiimikada ee recombinant erythropoietin i.e. ku dhirfinaya polycythemia heerka hiimotokiriit iyo oscillations. Sababo la la'aanta ah ee lidka-classic, tallaabooyin gaar ah oo ku saabsan deactivation ee maaddooyinka looma fuliyo - kaliya la joojiyay daawo kale ballan.

daadinta ula kac ah lagu dabaqi karo xaaladaha degdegga ah, markii tilmaame badan-xadka ah ee unugga muujinaysaa khatar dhab ah in ay nolosha.

Isdhexgalka la Medicines

In qabashada multi-yada therapy adag waa mid aad u muhiim ah in la fahmo mabaadii'da "dhaqanka pharmacological" "Epoetin Alfa" reagent (foomka sii daayo, sida kor lagu sharaxay, waxay noqon kartaa kala duwan, laakiin hab ay cadaanyo this lagmamaarmaanna aysan waxba ka beddelin).

Sayidka, gaar ahaan, la siman in hordhaca ah ee alaabta dhiig leedahay saamayn togan ku saabsan hagaajinta dhaqdhaqaaqii. Laakiin waa in aan xasuusano Barxo ee xal kale waa mid aan la'ogolaan karin. Daawada waa "union" cyclosporin ben la hoos-fiirsashada ee dambe (ratio si mug leh volumetric dose la go'aamiyo siman) ka.

Comments

Falanqaynta fikradaha ay muujinaysaa in tirada ugu badan ee su'aalaha kac marka ay timaado xulashooyinka diyaar u ah xalinta dhibaatada isku. Tusaale ahaan, dhowr ka mid ah bukaannada u yaqaanna in khilaafaadka ka qaadanayso meel u dhaxaysa waxyaabaha pharmacological sida, sida "Alfa epoetin" iyo "beta epoetin."

Waa maxay farqiga u - fududahay in la fahmo, hadii aan lacag bixisid si aad u comments dhakhaatiir dareenka. Xaqiiqada ah in model ah dhismaha ee erythropoietin dabiiciga ah waxaa wakiil laba silsiladood, la tarin on nidaamka dhiigga labada leeyihiin. Soo-saareyaasha ayaa isku daawada, sababtoo ah colaada ee technology, ama synthesize Alfa-jab ama beta.

Sida for comments on diyaarinta laftiisa, qaar badan oo ka mid ah kuwa lahaa in ay isku dayaan naftaada, show in ka dhigan tahay arrin wax ku ool ah, iyo xaaladaha gaarka ah qaar ka mid ah iyo dhamaan maarmaan waayo qaybaha qaar ka mid ah bukaanka.