Waayo, waa maxay ujeedada tijaabada waxaa la qabtaa Coombs?

Coombs - tijaabo gaar ah shaybaarka u ogolaanaya si loo ogaado unugyada difaaca ee plasma ama dusha unugyada dhiigga cas. nidaamka Tani waxay u ogolaaneysaa in la ogaado difaaca anemia hemolytic, oo ay ku jiraan dhashay, sidoo kale si loo ogaado reactions shubo hemolytic. Coombs si firfircoon loo isticmaalaa in cilmi sayniska foreensiga iyo genetics si loo ogaado cudur erythrocyte ah. Compliance leh oo dhan xeerarka falanqaynta noocan ah waxay fursad si aad u hesho natiijooyinka ugu kalsoonaan karo.

Ujeeddada imtixaanka antiglobulin

imtixaanka Direct Coombs lagu ogaan karaa unugyada anti-erythrocytic, kuwaas oo go'an on erythrocytes ah. dareen-celin wanaagsan marka daraasad la mid ah tilmaamay, in horumarka, shalalka anemia hemolytic. Waa in la ogaadaa in natiijo xun kama saarayso joogitaanka cudurka shalalka, tan iyo antibodies badanaa laga helaa qaab xor ah, i.e. aan xiriir la lahayn erythrocytes. Xaaladaha noocaas ah waxaa lagu talinayaa in la fuliyo baaritaanka Coombs aan toos ahayn, taas oo go'aan ka gaadhi doona wakiilada maamulka ee serum.

Sidee waa falanqaynta?

W dhiig-arooriyaha bukaanka guraa waa la fuliyay calool madhan subaxdii, inkastoo xaqiiqda ah in wax kasta oo arrimo muhiim ah in ay saameyn ku natiijada kama dambaysta ah ee imtixaanka this, waxaa lama soo dejin. wax Store ogol qaaday at 2 ilaa 8 ° C aan ka badnayn toddoba maalmood ah. Si tilmaamayaasha daraasaddan ahaayeen sida saxda ah ee suurtogalka ah, dhiigga oo dhan inta lagu jiro labada saacadood ee ugu horeeya in la geeyo shaybaarka. Sida habboon tijaabada Coombs waa in ay muujiyaan natiijo xun, taasoo muujinaysa maqnaanshaha isbedel hemolytic ee jirka.

Deciphering wadaraha

Coombs waa hab cilmi halkii caadi ah, taas oo u baahan si taxaddar leh oo sax ah. Marka la isticmaalayo imtixaanka noocan oo kale ah waxaa laga yaabaa in la kulamay dhibaatooyin qaar ka mid ah in ay yihiin xiriir la leh fasiraadda aan sax ahayn oo ka mid ah natiijada kama dambaysta ah ay sabab u tahay muujinta daciif ah reactions wanaagsan. Waa in la ogaadaa in falanqaynta unreliability ah - kuwaas oo wanaagsan Coombs - waxaa laga yaabaa in natiijo ah oo hawlqabad la'aan xiriir erythrocytes dhaqashada dufan
dusha iyo dhexdhexaadnimada qaybaha antiglobulin reagents serum. khasaaro kale ee habkan waa xasilooni darro ah waxyaabaha waxbarasho qaaday shubo taas oo uu leeyahay muuqaalada qaarkood.

Sababta oo ah natiijada been-negative noqon kartaa xad-dhaaf ah oo ganaax ruxaya ee erythrocytes in resuspension. Natiijooyinka khalad sidoo kale sabab u noqon kara jiritaanka nijaasta antibody anticomplement kuwaas oo adsorbed dushiisa lagu jiro cudurku ee erythrocytes imtixaanka, oon ku abuuraya muuqaalka kore ee natiijo wanaagsan. Haddii aad si taxadar leh ku dhaq-baaryada oo loola socon lahaa xaaladda falcelinta, khasaaraha, kuwaas oo si fudud la suulin karin, taas oo kordhinaysa fursadaha helitaanka tilmaamayaasha ugu kalsoonaan karo baaritaanka Coombs.