The daroogada "Celebrex": dib u eegista, analogs, tilmaamaha loo isticmaalo, qiimaha

guuldaradii dhabarta, xanuun aad u daran ee xubnaha iyo hawlaha isbedelka unugyo ku saabsan asalka ah ee caabuq - nasiib daro, cuduro kuwanu waxay ahaayeen kuwa ugu badan ee aannu mar. On xaaladda noocan ah saameeyaa hab nololeed, la'aanta dhaqdhaqaaqa jirka caadiga ah, xaaladaha firka. Waxa intaa dheer in xanuun aad u daran in dadka ku xanuunsado in xaaladda this, hadyada meejeeda, oo awood u baabbi'iyeen shaqeeyo oo dhan, beddelidda kiimikada dhiigga iyo saamaynaya hawlaha caadiga ah ee xubnaha gudaha.

Sidaas awgeed waa muhiim in lala socdo caafimaadka iyo waqti in lagu daweeyo cudurka. Mid ka mid ah daawooyinka inta badan wax ku ool ah, kaas oo iska leh kooxda ee daawooyinka aan steroid ahayn yeedhay medicament "Celebrex". Reviews dhakhaatiir xaqiijin ah waxtarkeeda marka la barbardhigo line la mid ah daawooyinka anti-bararka.

Saamaynta ugu weyn ee daroogada

Faa'iidada of daroogada waxaa loo yeedhi karaa awooddiisa ah inuu xakameeyo hawlaha nidaamka bararka marxaladaha kala duwan ee cudurka. Marka dhiigga, daroogada waa awoodaa inuu xakameeyo nidaamka TSOG2 keenta in gargaarka ah caabuq. "Celebrex" daroogada waxay leedahay hantida xanuunka a hawl qandhada xoog leh. Sidaa darteed, ma aha oo kaliya ay meesha Axdigu barar ah, laakiin sidoo kale si fiican u saaraysaa xitaa xanuun aad u daran, yaraynaysaa qandho.

Faa'iidooyinka wax soo saarka waxa ka mid ah ay saamayn yar ku platelets ah, in uu yahay, daroogada ma keeno dhibaatooyinka xinjirta dhiigga. Marka aad hesho wakiilka a non-steroidal in uu jiro cuncun lahayn oo ka mid ah caloosha iyo mindhicirrada, yareeyo khatarta hore-boogaha iyo bukaanka gastritis.

Sidaa darteed, ee kaniiniga "Celebrex" waxaa loo isticmaalaa waxyaabo kale oo badan si ballaaran ka badan daroogada NSAID kale, "naproxen", "Aspirin", "ibuprofen".

jiho

kaabsoosha "Celebrex" awood u leeyihiin in ay yareeyaan darnaanta xanuunka si wadajir ah, qallafsanaan la baabi'iyo inay la qabsadaan barar xad-dhaaf ah. gaadhista noocan oo kale ah ay suuragal tahay in lagu daweeyo bukaanada qaba cudurka rheumatoid arthritis, osteoarthritis. Saamaynta daroogada gaaro saamaynta ugu badan wuxuu ahaa 24-48 saacadood ka dib marka ugu horeeysa ee. daroogada Dysmenorrhea wax ku ool ah ay meesha xanuunka, xitaa ugu ba'an. Sidoo kale, waxaa si waxtar leh loo adeegsado gargaarka ee xanuun ka dib markii qaliin (maxillo-wajiga iyo qalliinka lafaha).

Bukaanka qaba spondylitis ankylosing daroogada "Celebrex" fogaado habka cudurada iyo hagaajinaysaa awoodda jidhka ee uu u shaqeeyo. Marka logu dhaqdhaqaaqa of qoyska isticmaalka polyposis adenomatous daroogada keentay in hoos u dhac weyn ee koritaanka of polyps ee mindhicirka iyo malawadka: yareeyo tirada iyo baaxadda. Dhakhaatiirta sheegan in qaadasho ku filan daawada iyo u hogaansanaanta daaweyntu socoto gaari karo natiijooyin fiican iyadoo la isticmaalayo "Celebrex" daroogada. Kurtumm tusi waxyeellooyin yar inta aad qaadanaysid dawadan.

The qaab iyo Halabuurka daroogada

Aadka inhibitor la xushay waa kaabsal gelatin a ku dhowaad caddaan ama caddaan, ma ay joogaan hufan oo waxaa lagu calaamadeeyay leh strips buluug ah ku tilmaamay "7767" hal dhinac iyo "100" iyo "200" oo dhinaca kale ah. waxyaabaha kaabsol: granulated midabaynta cad.

Halabuurka The daroogada waxaa ka mid ah: celecoxib (qayb aasaasi ah oo firfircoon), lactose, K30 povidone, sodium lauryl sulfate, milmahayn magnesium, sodium croscarmellose. qolof ah laga sameeyey oo titanium dioxide, iyo gelatin la cuni karo. Haddii maamulka ku habboon oo ka mid ah irbado intramuscularly daroogada waxaa loo magacaabay "Celebrex". Noocan daawada ah laga saaro qaab xal la isku duro of 2.2 ml ampoules - celecoxib walax aasaasiga ah.

Pharmacokinetics

daroogada ayaa waxaa si fiican u nuugo galay dhiig ee gobolka soonka iyo gaaro waxqabadka ugu badan ka dib ku saabsan 2-3 saacadood. Si kastaba ha ahaatee, isticmaalka hab wada jir ah ula cuntada dufanka leh a dib u dhigi karaan ay raasamaal 1-2 saacadood. Sidaas awgeed waa lagama maarmaan in la tasho dhakhtar oo ku saabsan waqtiga daawada.

Marka dhiigga, walxaha firfircoon ha ku xidhaan in unugyada dhiigga cas, laakiin hab ay wax saameyn ah kuma guusha ee-fiirsashada la rabay ee daroogada ah ee jirka ku. Drug metabolized beerka by qayilo iyo glucuronidation lug enzyme CYP2C9. Output ka dhigan tahay iyadoo kaadida iyo saxarada qaab metabolites fudud, iyo% oo ah walaxda firfircoon oo kaliya 3 isma badelin.

Drug "Celebrex", analogues kuwaas oo la mid ah in Halabuurka, helay hab, keenaya waxyeello yar caafimaadka, sababtoo ah halka ay awoodda in la nuugo sida ugu badan ee suurto gal ah iyo ku dhowaad si buuxda u hartay jirka. Iyada oo miisaanka jirka oo hooseeya arkay uruuray sare ee daroogada ee dhiigga, iyo this ifafaale ayaa lagu arkay in ka badan haweenka. Lama oga sababta, laakiin sidoo kale in dadka kiiyoo arkay dhaqdhaqaaqa isku. Sidaa darteed, kuwaas oo kooxaha bukaanada qoray qiyaas hoose ee daawo bilowga ah ee daaweynta.

Tilmaamayaasha

Sida a non-steroidal anti-bararka wakiilada for daroogada daaweyn astaamaha qoray "Celebrex". Tilmaamayaasha in loo isticmaalo:

• arthritis rheumatoid;
• osteoarthritis,
• spondylitis;
• algomenorrhea;
• xanuun ba'an (muddada post-operative, dhabar xanuun, muruqyada cudurada);
• loo isticmaalo daaweynta polyposis adenamotoznogo.

Waa in la ogaadaa in daaweyn ku filan u yeelaan karaan oo kaliya dhakhtar ku saleysan cilmi.

Hababka maamulka daroogada

Qaadashada daroogada waa in ay gudaha, iyadoo aan loo eegin hadhuudhka ah. kiniin la calaashado waa in aanay noqon, waxaad u baahan tahay in aad cabto biyo cad. Waa in la ogaadaa in dhibaatooyin wadnaha dhici karaan maamulka chronic ee daroogada. Sidaa darteed, dhakhaatiirta qori "Celebrex" Dabcan kooban ee daaweynta. khubaro Martida loo xaqiijiyo in qiyaasta ugu badan ee daaweynta mudada dheer waa in aanay ka badan 400 mg maalin kasta!

• Daaweynta osteoarthritis - filan dose waa 200 mg maalintii. Fursada dose hal ama kala galay laba (si joogto ah).
• Rheumatoid arthritis - dose filayaa of 100 ama 200 mg ilaa 2 jeer maalintii. Marka noocyada ugu daran - ilaa 400 mg laba jeer maalintii.
• Ankylosing spondylitis - 200 mg maalin kasta, waayo, 1 ama 2 qiyaasood oo kala qaybsan. In ikhtiyaar dhakhtarka qiyaasta laga yaabaa in la kordhiyo si ku filan aamin
• Dysmenorrhea iyo xanuun xoog leh - bilaabmaa therapy la 400 mg maalintii iyo ku daray 200 mg kale maalinta ugu horeysa ee daaweynta, haddii loo baahdo. In ka maalmood ee soo socda, waa in aad qaadato 200 mg laba jeer maalintii.

Duration daaweynta waxaa lagu go'aamiyaa uu dhakhtarka xaadirka ah.

Sababo isticmaalka daroogada

Waxa intaa dheer in dareen diidmo oo xasaasiyadeed suurto gal ah in dadka deegaanka ee daroogada, waxaa jira xayiraad hoostiisa waxaa ka mamnuuc ah oo isticmaalaya "Celebrex" daroogada:

1. neefta bronki, urtikaria, xasaasiyad NSAIDs kale.
2. Muddada postoperative ka dib markii isku tallaalidda aortkoronarnogo.
3. boog ulcer (daridda).
4. dhiig GI.
5. cudur mindhicireed barar leh.
6. Heart failure.
7. kaafi cagaarshowga daran.
8. kaafi kelyaha.
9. Uurka iyo nuujinta.
10. Ma talinayo in la isticmaalo ka yar 18 sano.
11. Diidmo u soo doortay oo ka mid ah daroogada iyo sulfonamides.

Taxadarka waa in ay isticmaalaan daroogada la dareeraha ee jirka, cudurada nidaamka wadnaha, cudurka macaanka.

waxyeellooyin

Inkastoo awoodba sare ee daroogada, hab dhaweynta dheer ama aan sax ahayn iyo qiyaasta noqon kartaa waxyeelo daroogada "Celebrex". Kurtumm tusi ugu badan ee calaamadaha (noqnoqda) sida:

• dareen diidmo oo xasaasiyadeed oo ay ku jiraan finan, urtikaria, pruritus.
• Yaaqyaaqsi, dyspepsia, barar, hurdo la'aan.
• Qufac, rhinitt, dareen-celin u eg hargab iyo caabuqyada neef-mareenka.
• cudurada kaadi mareenka.

Badan ka yar waxaa jira kordhay walaaca, dhiig yari, tinnitus, dareen, arrhythmia, hypertension halbowlaha. Bukaanjiifka qaar ayaa waxaa laga soo minguuriyay lagu yeesho ee marinka dheef shiidka, barar angionevropatichesky, formation of bullae on maqaarka, sii daridda ah ganaca ama dhinaca horumarinta, wareer. calaamadaha intaas oo dhammu waxay dhici kartaa oo keliya marka koorso of daaweyn waa kooban (ilaa 12 toddobaad, aan ka badnayn 800 mg). Laakiin in ay dhacdo daaweyn muddo dheer (ilaa 3 sano) waxaa lagu arkay:

• Common: niyad of a kursi, hypertension, caabuq gala dhegaha, angina, Wadnaxanuun myocardial, lalabo, dysphagia, prostatitis, kariyaatiniin kordhay.
• More dhif ah: arrhythmia, angina, stroke ischaemic, atherosclerosis, hurda, dhiig-bax siilka, boogaha afkaaga, dysmenorrhea ah, korodhka hemoglobin, hoos u dhac ku hiimotokiriit.

dhexgalka ee daroogada daawooyin kale

medicament The si firfircoon biotransformed lug P450 2C9 (cytochrome). Sidaas awgeed waa in dhexgalka suurto gal toos ah daroogada la wakiilada kale:

1. isticmaalka daroogada saameen "Warfarin" kordhiyaa halista dhiig-bax lagu dhinto.
2. Diyaarinta "Ketanazol" iyo "fluconazole" kordhin fiirsashada of celecoxib walax firfircoon labanlaab.
3. Qaadashada blockers ama celiyeyaasha ACE NSAIDs angiotenzita yareyn karaan antigipertinzivny saamayn
4. waxyaabaha isku dhafan oo ka kooban lithium, waxa si weyn u kordhin kartaa heerka dhiigga.
5. Waa mamnuuc in isku mar u isticmaalaan daroogada analogs ah "Celebrex" kooban celecoxib, NSAIDs kale!

analogues daroogada

Waxaa xusid mudan in "Celebrex" kharashka daawada aan aad u badan, oo ay qiimaha waa celcelis ahaan 400 450 rubles. 10 kaabsoosha (100 qiyaasta mg). Si kastaba ha ahaatee, daaweynta sida waa wax qaali ah therapy muddo dheer bukaan-socodka. Xaaladdan oo kale, wax ogolaansho ah dhakhtar, doorataa wakiilada ka kooban celecoxib. Waayo, daroogada "Celebrex" analogues ee soo socda:

• daroogada "Ranselak";
• daroogada "Revmoksib";
• kiniiniyada "Flogoksib";
• kaabsal "Artoksib".

analogs waxa ku jira walax isku mid ah oo firfircoon oo ay leeyihiin saamayn ku ool ah isku-daweynta ee daawaynta cudurada. Ogsoonow in qiyaasta ku filan ee analoogga ah ayaa sidoo kale loo xilsaaray kaliya uu dhakhtarka xaadirka ah. Xaaladdan oo kale dhakhtarku u arko qalabka Halabuurka kala duwan ee analogs, waxay ka kooban daro kala duwan marka loo eego daroogada "Celebrex". Waxbarashada dib u dhakhaatiirtu soo jeedin suurtagalnimada of dareen xaasaasi ah by bukaanka u excipients daawooyinka kala duwan hal group.