"Plagril": tilmaamaha loo isticmaalo, dhakhaatiirta dhabta ah. analogues Drug "Plagril"

Cudurada of nidaamka wadnaha waa in daawo casri ah laga yaabee in meesha ugu horeysa. Heerka dhimashada ka cuduradan waa ugu sareeya. Waxaa jira dhibaatooyin degaanka in noqnoqon karaan qof ka xaadirka ah ee dhalashada. Si kastaba ha ahaatee, waxaa jira kuwa taas oo horumarka qofka u gaar ah kana soobixiya wax badan "qaaraan". Mid ka mid ah cudurada sida - atherosclerosis. Haddii dhibaatadan inta badan saameeyaa halbowlayaasha nooca-muruqa dabacsan iyo laastikada. Nuxurka cudurka in, ay sabab u tahay xadgudubyada protein iyo shiid la egyahay ururto halbowleyaasha of kayd kolestarool ah iyo dadka deegaanka ee qaar ka mid ah Lipoproteins. Sayidka sameeyay dabar atherosclerotic. Waqti ka, nudaha connective derbiyada weel ku dabar kuwaas ballaariyo, taasoo keentay in meel cidhiidhi ah Lumen ee halbowlaha ilaa qabsamin ah.

In si ay u caawiyaan bukaanada kuwan, cilmi yeelatay liiska daroogada in hoos u dhigi karaan ama gabi ahaanba lagu cabudhinayo habka xulkii (xeryahooda, lagala kulmo) ee platelets. Muqaadaraadka la awoodaha noocan ah waxaa loo yaqaan antiplatelet (antithrombotics). Mid ka mid ah daroogada oo kale waa "Plagril".

Qaab dhismeedka iyo Curiska

daroogada waxaa laga heli karaa kiniin dahaarka leh kula casaan daahan filim. Kiniinnada waxaa ku wareegsan, biconvex. On hal dhinac sarreysa embossing "C 127". The qayb weyn ee firfircoon ee daroogada - clopidogrel. Waana mid ka, ee daroogada ah "Plagril" INN (International noocan Name) waa inay isku magaca qayb weyn ee - clopidogrel. content The mugga, halkii kaniini - 75 mg. Ka sokow qaybaha ugu muhiimsan ee medicament waa excipients: cellulose mikrokristallin, mannitol, sodium croscarmellose, Silicon Kolloidol dioxide, milmahayn magnesium. Soo-saareyaasha ayaa soo saari daroogada ee baakad fin of 10 xabbadood.

farsamo ee daroogada

Daawada waa inhibitor gaar ah - xulkii (joogsada joogsada, cabudhinayo geedi socod kasta) (xarunta) platelets. Waxay leedahay tallaabo koronarorasshiryayuschee. Hab-deceleration xulkii dhiig xinjirowga (40%) waxaa lagu arki karaa 2 saacadood ka dib markii uu qofku cuno ee daroogada ee qiyaasta ah 400 mg ka dib. Si loo gaaro hufnaan ugu badan (60% Iscelin of xulkii) saamaynta ka kiniin "Plagril", tilmaamaha loo isticmaalo sidii baahida loo qabo therapy for 4-7 maalmood. Qiyaasta guud ee maalin kasta waa in 50 ilaa 100 mg. Xaaladdan oo kale, saamayn antiplatelet socon doono mudo wareegga oo dhan nolosha ee platelets (7 ilaa 10 maalmood). 5 maalmood ka dib bixitaanka heerka daroogada ee xulkii dhiig xinjirowga, iyo waqti dhiig-in-qabadka hore dib gudahood.

Raaca "Plagril" kelyaha iyo xiidmaha (50% iyo 46% siday u kala horreeyaan). deducing Period - 120 saacadood ka dib markii maamulka.

The macaamiisha ugu muhiimsan ee "Plagrila"

Waxaa jira koox gaar ah ee bukaanka wadnaha kuwaas waxaa lagu muujiyey in aad codsato daawada "Plagril". Tilmaamaha waxaa looga baahan yahay in ay qaataan daroogada ah dadka ka cabanaya atherosclerosis. Daawada waa wax ku ool ah sida qiyaas ka hortag ah si loo yareeyo halista jahawareerka la xiriira thrombosis in dadka isa soo Wadnaxanuun myocardial infarction ama stroke ischaemic. Sidoo kale waa run dadka buka ee ka qabsamin (oo sii daraysa ee permeability) halbowlayaasha durugsan.

In la kala dhantaalay acetylsalicylic acid (aspirin) waxaa loo isticmaali karaa "Plagrila" si looga hortago dhibaatooyin thrombotic in kuwa ay dhibaatadu ka ba'an syndrome wadnaha. Tani waxay ka mid noqon kara dadka qaba angina (foomka deganayn), la Wadnaxanuun myocardial aan formation ruxruxo Q. Waxaad isticmaali kartaa daroogada ee bukaanka stenting maray. Nuxurka hawlgalka - rakibo ee stent ah weel saameysey (tube biraha ganaax-meshed khafiif ah), taas oo markii danbe waa laga badbadiyay buufin gaar ah, markaa si ay kordhaan permeability ee markabka iyo hagaajinta dhiigga ku shubma wadnaha ah.

hababka codsiga: Qiyaasta

Medicine bukaanka "Plagril" loo qaadan karaa afka, iyadoo aan loo eegin cunto. In dadka buka lagu Wadnaxanuun myocardial, stroke ischaemic ama cudurka la aasaasay oo ku saabsan patency ee sii xumaanaysa halbowleyaasha, qiyaasta of 75 mg qaataa hal mar maalintii. Muddada daaweynta daawada ka dib Q-ruxruxo Wadnaxanuun myocardial kor socon karaa ilaa 35 maalmood. In stroke ischaemic, ku xiran tahay darnaanta xaaladda, daawo u dhaxayn kartaa 7 maalmood in ay muddo lix bilood ah.

Marka stroke qaab aan daganayn ah, iyo Wadnaxanuun myocardial aan formation of Q-ruxruxo caadi ahaan waa mudada caadiga ah ee kiniiniyada waa sida soo socota: marka hore, hal mar qiyaas loading of 300 mg, raaceen by 75 mg maalintii ay la socdaan aspirin (75 325 mg maalintii). Maxaa yeelay, qaadashada ee aspirin kordhiyaa halista dhiig-bax, qiyaasta ugu badan ee hal waa in aanay ka badan 100 mg. daaweynta Drug - ilaa 1 sano.

soo dhaweynta "Plagril" therapy antiplatelet ayaa sidoo kale tilmaamay for Wadnaxanuun myocardial ba'an. U qoraan dadka kiniiniga in ay qaataan at dose oo ah 75 mg, in hal maalin. Waxa lagu talinayaa in la bilaabo daweynta, qiyaasta loading hore isku dhafan oo acetylsalicylic acid. Waxaa laga yaabaa in thrombolytics qaadashada isku midka ah (ama laga yaabaa in aanay qaadan).

Haddii bukaan ayaa u gudbay 75 sano da'da xaddidan, "Plagril" (oo la mid ah clopidogrel sidoo kale waa la aqbali karo) waxaa loo doortay iyada oo aan qiyaas loading hore. Ka dib markii muuqaalka kore ee daaweynta isku dhafan ee calaamadaha waa in la bilaabay sida ugu dhaqsaha badan. Dabcan waa in ugu yaraan 4 todobaad.

Cilladaha

Inta lagu guda jiray daaweynta diyaarinta "Plagril" diiwaanka wargelinaysaa in noocyo kala duwan oo waxyeelo ay suurto gal ka hababka kala duwan iyo xubnaha.

nidaamka xinjirowga dhiigga inta badan ka jawaabi karaan muuqaalka kore ee dhiigbaxa caloosha iyo mindhicirka. In ka yar inta badan laga yaabaa in stroke dhiigbaxa, dhiigbaxa sanka iyo, guud ahaan, korodhka waqtiga dhiig. Marar dhif ah, ayaa laga yaabaa inuu hematomas, hematuria.

qaab oo kala duwan ka soo nidaamka hemopoietic. Kuwaas waxaa ka mid eosinophilia, neutropenia, Torombositobiiniya. Si weyn u yar tahay in ay horumariyaan granulocytopenia, dhiig oo fudud ama aplastic.

On qayb ka mid ah habdhiska dhexe iyo durugsan laga yaabaa in madax xanuun, wareer, paresthesia, vertigo (luma dheelitirka, Ulasocto dareen wareeg oo alaab ah oo jidhka ah, ama qeybsanaan - jirka ah ee wareeg), dhalanteed, wareer. Waxay jeelyihiin in dhif ah, laakiin xaaladaha dhacdooyinka xun dhacaan nidaamka wadnaha iyo, marka la eego cadaadiska dhiigga oo hoos u, horumarinta vaskulitis. Bronchospasm iyo pneumonitis interstitial - this waxaa laga yaabaa in uu cadaanyo ba'an ee qaabka neefsashada si ay u helaan daawada.

Inta badan daawo "Plagril" (dib u eegista ah dhakhaatiirta iyo bukaanka xaqiijin xaqiiqda) sameynayso nidaamka dheefshiidka. falcelinta ee jirka waxaa la muujiyey in horumarinta shuban, dyspepsia, calool xanuun. reactions suurto gal ka yar caadiga ah sida lalabo, matag, calool, gastritis ba'an iyo gastric iyo dyspepsia, yaaqyaaqsi. dhacdo dhif ah laakiin suurto galka ah ee cudurada sida colitis, ganaca, stomatitis, hepatitis, dhadhanka doorsoon, horumarinta beerku failure.

nidaamka Osteo-muruqa laftiisa sheegi kartaa arthritis, myalgia. In kasta oo ay dhacdo dhif ah. Glomerulonephritis ku keeni karta dareen-celinta nidaamka kaadida. Xirfadleyaasha haragga ee soo jeedinaya in natiijo macquul ah "Plagrila" waa cuncun, finan bullous, finan erythematous, lichen planus ', cambaarta. Waxaa laga yaabaa in horumarinta dareen diidmo oo xasaasiyadeed oo ah qaab anjioedema, anaphylaxis, bukaanka serum. Oo ka mid ah waxyeellooyin caadi ah in la ogaadaa laga yaabaa in qandho, kariyaatiniin serum kacsantahay.

Isticmaalka "Plagrila": waxa la raadinayo

Haddii xaalad gaar ah saameyn antiplatelet aan loo baahnayn, ama waa inay qalliin, waa in aad baajiso daweynta leh "Plagril". Tilmaamaha loogu isticmaalo talinaysaa in ay sidaa sameeyaan ugu yaraan 7 maalmood ka hor qalliinka. Ka dib markii la baabiiyo of daroogada si loo joojiyo dhiigga si lama filaan ah ku bilowday baahan doonaa waqti dheeraad ah. Bukaan-socodka waa in loo digay oo ku saabsan iyo talinayaa in la wargeliyo takhtarka ku saabsan dhiig kasta oo aan caadi ahayn. In danta bukaanka in la wargeliyo takhtarka ku saabsan daaweynta "Plagrilom" mararka kuwa, haddii ay noqon qaliin kasta, ama bukaan-socodka lagu qoro wax daroogada cusub.

In koorsada of therapy caafimaad waa muhiim in gacanta ku koobin nidaamka of homeostasis ah (xinjirowga tirin, imtixaanada dhaqdhaqaaqa functional, APTT). Waxqabadka functional ah ee beerka iyo waa in la joogto ah u ilaaliya iyo qiimeeyo sida leexashooyinkaasi daran in ay shaqada sii kordhi karta halista in diathesis hemorrhagic.

Medicaments, kuwaas oo ugu weyn ee firfircoon yahay clopidogrel (analogs "Plagril"), laguma talinayo kuwa soo gaaray ah Wadnaxanuun myocardial ba'an, ugu yaraan inta lagu guda jiro dhowr toddobaad ka dib bilawga ugu horeysay. xirfadlayaasha caafimaad ha ku talinaynaa "Plagrilom" therapy haddii bukaanku leeyahay angina deganayn, la stroke ischaemic ee qalliinka isku tallaalidda wadnaha.

Iyada oo xaddi gaar ah oo digniin laga rabaa inay qaataan daroogada ah oo loogu talagalay dadka naafada ah ee ku shaqaynaya ee kelyaha.

Si looga hortago-dhawaynta "Plagrila"?

"Plagril" (kiniin) edbinta mamnuucayaa bukaanka qaba diidmo ama dulqaad in qaybaha ugu muhiimsan iyo kaabayaal ah oo shakhsi ah medicament ah. Ha qaadan daawada kasta cudurada xasiloooni dhiig kaa yimaado (gastric iyo dyspepsia, hyperfibrinolysis, kansarka sanbabada, qaaxada, iwm). saldhig A xoog leh oo ah ku-isticmaalka aan "Plagrila" waa failure cagaarshowga ba'an, dhiigbaxa syndrome. Waxa intaa dheer in kor ku xusan, waa u qaataa daawo loogu tala galay dumarka uurka leh iyo hooyooyin carruurtaada nuujiya. Ma aha in la qoro daroogada si uu caruurta ka yar 18 sano jir.

Diyaargaraw analogues

In suuqa dawooyinka maanta, koox ka mid ah daroogada wakiilada antiplatelet ( "Plagril" micne ah ay ka kooban oo ka mid ah qaybaha ugu muhiimsan ee firfircoon) la heli karo ku filan si ballaaran. In ka badan 3 darsin daroogada - wakiilada antiplatelet leeyihiin qayb ka mid ah oo firfircoon (clopidogrel) iyo qiyaasta la mid ah (75 mg). ka saarayaasha Ruush reebo soo saaraan shirkadaha Indian antiplatelet dawooyinka, shirkadaha Hungary, Israa'iil, Malta, France.

"Dr. Reddies Laboratories" "Plagril" laftiisa soo saarta shirkad Indian. Isu ekaysiinta, waxaan ka mid noqon kara ee "Plavix" Jarmal "ratiopharm Clopidogrel," Faransiis Hungarian "Clopidogrel-Richter," Israel "Clopidogrel Teva," Malta "Liporel" Makedoniya "Listab 75". "Zilt" la takooro karaa ugu caansan oo si ballaaran in baahida wakiilada Ruush.

"Zilt" - Ruush "Plagril"

The walax ugu weyn ee firfircoon ee diyaarinta "Zilt" ( "Plagril" in in ay si buuxda u waafaqsan tahay) waa clopidogrel. Daawada iska leh kooxda ee wakiilada antiplatelet. Qiyaasta hore (for "Zilt" - 400 mg) 2 saacadood ka dib markii maamulka ka dib markii loogu talla galay xulkii dhiig xinjirowga. Sida "Plagril", "Zilt", la siiyaa helo 50-100 mg maalintii siin doonaa saamaynta ugu badan ku daweyn 4-7 maalmood ka dib.

Medicament metabolized beerka. The Halabuurka ee dhiigga ee metabolites firfircoon ee la ogaado. Qiyaastii 50% "Zilta" saxarrada kelyaha, ka harsan tahay 46%, 5 maalmood gudahood ka dib markii aqbaliddoodii noqon doonaa iyada oo loo marayo xiidmaha.

Tilmaamayaasha in loo isticmaalo ee ah "Zilta" waxay la mid yihiin in "Plagrila": ka hortagga formation thrombus in bukaan qaliin Wadnaxanuun myocardial, stroke ischaemic ama ka cabanaya xanuunada patency halbowlaha.

opinion macaamiisha

Like daroogo kasta, "ayuu Plagrila" ayaa labada qiimeynta wanaagsan ee macaamiisha, labada dib u eegista togan iyo kuwa taban. Waxaa jira bukaan kan daroogada ayaa loo magacaabay for daaweynta angina oo naftiisa daroogada aad wax ku ool tusay. Iyada oo ay isticmaalaan weerarro ka dhacay ama at dhan, ama waxay noqdeen yar. Wada jir ah ula macaamiisha ee qiimaynta daawooyinka "Plagril" jawaab ka dhakhaatiirta.

Si kastaba ha ahaatee, waxaad kula kulmi kartaa iyo indha indheyn ku saabsan dhibaatooyinka soo raaca sababa isticmaalka daawada. Dadka qaar ayaa qoray oo ku saabsan muuqaalka kore ee burbur, qaar kalena si cad u muujiyey anemia. Waxay ahaayeen bukaanka iyo dhacdooyin madax xanuun aad u daran, iyo cudura jiho aad u kala duwan ee habka dheef shiidka. Rare, laakiin waxaa la maqli karaa on sare ee habka la helo "Plagrila" boog gastric ama boog dyspepsia.

Guud ahaan, waa in la sheegay in ay daroogada "Plagril 'tilmaamaha loogu isticmaalo waa taagan yahay sida daroogada ku filan halis ah lama jaanqaadi karaan dawooyinka oo dhan. Liiska cadaalad ah oo ballaaran sababo, wax badan oo waxyeelo u keeni karaa noocyo kala duwan oo nidaam iyo xubnaha. isticmaalka la xakamaynin wuxuu ku dhiiri galin kartaa xun ku filan (oo mararka qaarkood karin) cawaaqib caafimaadka bukaanka.

Go'aanku wuxuu ka kor ku xusan oo dhan waa cad cad. "Plagril" koorsada daaweyn waa in la magacaabay uu dhakhtarka xaadirka ah. Iyo ikhtiyaarka ugu fiican ee lagu daaweeyo daroogada this - isbitaalka iyo iyada oo ay kormeerayaan khubaro hormood ah. Kaliya kiiskan aan qabi karaan saamayn togan ee daroogada halis yar ee waxyeelo.