Drug "Armadin": tilmaamaha loo isticmaalo (irbadaha)

Si aad u taariikhda, daroogada "Armadin" waxaa sii kordheysa helay dhaqanka caafimaad oo casri ah. Tilmaamaha loogu isticmaalo (irbado - aan loo tixgeliyaa qaabka) ee qalabka waa wax adag, waayo, horumarinta, oo xidhiidh la leh taas oo dad badan oo door bidaan in la raadiyo xog dheeraad ah laga heli karaa.

Next aan eegno sida qalab ay tahay, waa maxay faa'iidada iyo khasaaraha ay, iyo sidoo kale sidii ay u si fiican u isticmaalin.

pharmacodynamics

"Armadin" waa inhibitor ah oo khaas u ah hababka free-xagjirka, waa sokeeye xuub. In geeddi-socodka ah ee la helo hab waa nootropic, antihypoxic, stressoprotektornoe iyo saamaynta anxiolytic, daroogada ayaa sidoo kale si weyn u kordhiyaa caabbinta in ay saameyn ku leeyihiin arrimaha waxyeello kala duwan kislorodzavisimym iyo dalalka bahal ah.

By daroogada tilmaamaha "Armadin" loo isticmaalo (irbadaha) Qoraallada Hagidda xaqiiqda ah in waxa la isticmaalayo hagaajinaysaa socodka cerebral dhiig iyo dheef cerebral, hoos trombotsiotov xulkii, wanaajiyo rheology dhiig iyo microcirculation. Isla mar ahaantaana inta badan dhakhaatiirtu liiska firfircoon oo dhammeystira in in habka loo xilsaaray sabab u ah xasilinta dhismayaasha xuub hemolysis unugyada dhiigga marka, ay soo dhaweynta sida hoos sarkhaan enzymatic qoomiyadda iyo toxemia in ay dhacdo ganaca ba'an.

Sidee u shaqeeyaan?

Enough qeexayaa macnihiisu yahay "Armadin" farsamo ee diiwaanka ficil (irbadaha), sababo, iyo meelaha kale. Operation of this ka dhigan tahay waxa keena membranoprotektornym iyo saamaynta antioxidant. In geeddi-socodka ah ee qaata hawlaha sii kordhaya ee dismutase superoxide dhaxalsiiyeen peroxidation la egyahay korodho ratio "egyahay-protein", iyo hoos u ku nafwaayay ee xuub, sidaasna ay ku kordhiyaan ay isbeddello. Intaa waxaa dheer, soo dhaweynta ah ee daroogada modulate karaa waxqabadka of falgalka kala duwan oo adag receptor xuub-ku xidhay, taas oo uu leeyahay saamayn togan ku awoodooda inay xidhxidhaan si ligands iyo ilaaliyaa ururka dhismaha iyo hawlaha gaarka ah ee xuubka noolaha.

fiiro gaar ah in la bixiyo, in ay xaqiiqada ah in in daroogada "Armadin" diiwaanka (irbadaha) qeexaya qaababka ugu muhiimsan ee ay hawlgalka iyo sidoo kale muujinaysaa caadi ah hababka dheefshiidka ee myocardium ah ischaemic, hoos u galleeyda, hoos iyo horumar ku xiga ee dhaqdhaqaaqa korontada iyo contractility ee myocardium ah, iyo sidoo kale kordhaya ee socodka dhiigga wadnaha ee degaanka ischaemic. Waxaadna helaysaan waxa taasi ka dhigan tahay in ay gacan ka ilaalinta muddada-dheer ee unugyada ganglion isha iyo macdantaa dareemayaasha optic lacala neuropathy horusocod ah, taas oo keeni karta in hypoxia chronic iyo ischemia.

Waxaa ka mid ah waxyeelada kale waa horumar gaar ah xusid mudan in hawshu functional of optic nerve retina, taas oo kordhinaysa toosan muuqaalka qofka.

Pharmacokinetics

By maamulka muruqyada dhexdooda daroogada waxaa lagu go'aamiyaa iyadoo adeegsanayo in plasma dhiig muddo ka badan afar saacadood ah. Markii ugu total si ay u gaaraan C _max waa inta u dhaxaysa 0.45 ku saabsan in 0.5 saac.

Waxaa xusid mudan in xaqiiqda ah in daroogada waxaa si deg deg ah uu bilaabay in uu ka dhiiga guurto unugyada kala duwan iyo xubnaha, ka dibna jirka oo ka hartay. Tani waxay dhacdaa in kaadida, kiisaska intooda badan qaab glyukuronkonyugirovannoy faa'iidada badan iyo tiro yar, iyo foomka iska beddelin. Waxaa si gaar ah diyaarinta lagu soo bandhigay this "Armadin" (irbadaha). Halabuurka The qalab this ka mid ah emoxypine in si deg deg ah u nuugo in mareenka caloosha iyo mindhicirka.

Emoxypine ee jidhka bini'aadamka uu bilaabo inuu metabolize arrin culus oo la hoos dheeraad ah oo ay glyukuronokonyugata. Xaaladaha intooda badan in ka badan qiyaastii 12 saacadood faa'iido saarka kaadida oo ku saabsan 0.3% daroogada beddelin, halka 50% - oo ah qaab glyukuronokonyugata ah.

xoogooda ugu badan eilmetilgidroksipiridina succinate ay weheliyaan uu glyukuronokonyugatom raaca inta lagu jiro afarta saacadood ee ugu horeeya ka dib markii la isticmaalayo daroogada this. Marar badan, oo macneheedu yahay ee "Armadin" (shots) ee dib u eegista dhakhaatiir ka mid ah xogta in Digo in xuduudaheedu kaadida ee element iyo metabolites ay kala duwan yihiin tirayn shaqsi badan.

Marka waxa laga soo qaatay?

Sida la og yahay, qalab waxaa laga heli karaa in laba nooc - a irbado caadiga ah iyo kiniiniyada. doorasho kasta waxaa loo isticmaalaa in noocyo kala duwan oo ka mid ah xaaladaha, si aad u baahan tahay in si fiican loo fahmo marka iyo nooca ugu fiican in aad doorato. Xaaladaha intooda badan dhakhaatiirta faa'iidada badan kuwaas oo qoray qalab, foomka madax bannaan ayaa tilmaamaya in ay soo dhaweynta.

irbado

By (shots) daroogada "Armadin" war muujinaysaa in sidan isticmaalkeeda lagu muujiyay xaaladaha soo socda:

• joogitaanka xanuunada ba'an ee wareegga cerebral nidaamka;
• cawaaqibka dhaawac kala duwan maskaxda;
• cardiopsychoneurosis;
• encephalopathy;
• joogitaanka disorder wax walaaca lagu jiro neurosis percolation iyo dalalka ka waalan,
• yar kala dhantaalnaan fahanka in Bilowgii ee atherosclerosis,
• dhacdo of glaucoma hoose furan xagal ee marxaladaha kala duwan (haddii ay taasi si daroogada "Armadin" (irbadaha) edbinta ku qeexan yihiin in ay la isticmaalo lagu muujiyay sida element isku dhafan ee therapy);
• gargaarka ee astaamaha u-barashada in ay dhacdo Khamriga, haddii heysatay xanuunada neurocirculatory iyo neurosis-sida.

kiniiniyada

Qaabkan daroogada waa muujinaya xoogaa kala duwan loo isticmaalo:

• neurosis ama waalan dalalka leh calaamado kala duwan oo walwalka,
• cawaaqibka xanuunada ba'an ee wareegga cerebral nidaamka;
• cardiopsychoneurosis;
• Bilowgii kala duwan encephalopathy;
• Light xanuunada garashada of Bilowgii kala duwan;
• xasuusta oo yaraada, ama joogitaanka deficiency maskaxda ee dadka ku jira da 'weyn;
• dhaawac madaxa yar iyo cawaaqibka ay;
• absinentny syndrome khamriga ay goobjoog ka ahaayeen neurosis autonomic ama xanuunada vascular,
• xaaladaha asthenic kala duwan ama gaadhista arrimaha ba'an;
• xaalad sarkhaan danbe horumariyo hab antipsihotropnymi kala duwan;
• cudurka halbowlaha wadnaha,
• Wadnaha ee therapy isku dhafan;
• dislipoproteinemia nooca atherogenic.

Sidee irbado?

Sidaas dhakhtarku qoro daawada "Armadin". Cirbadaha intramuscularly ama faleebo maamulo u dareerin karaa ama jet. Qiyaasta kiis kasta oo lagu doorto si gaar ah isticmaalaya hab shakhsi ah, sidaas darteed waa in la qabtay dhakhaatiir aqoon u leh.

Marka la isticmaalayo hab this maamul ee diyaarinta galiyey waa in la furo in xal sodium chloride nafsaaniga ah. Waxaa lagu talinayaa in la bilaabo daweynta dadka waaweyn ee qiyaasood oo ka soo 50 ilaa 100 mg, kaas oo ay maamusho hal ilaa saddex jeer maalintii. Muga Ka dibna waa la kordhin karaa, kaas oo la tilmaamay in ay daroogada "Armadin" (irbadaha) edbinta. ampoules waxa ku jiri daroogada laftiisa, oo waa in lagu maamulo si tartiib ah in ka badan 5-7 daqiiqo jet, halka faleebo ah "Armadin" waxaa soo bandhigay ee ku saabsan xawaaraha 40-60 dhibciyo daqiiqad kasta. Ugu badnaan dose suurto gal ah maalin kasta ee medicament waa 800 mg.

In jiritaanka xaalado ba'an ee wareegga cerebral in nidaamka of daroogada waxaa la siiyaa oo qayb ka ah daawada isku dhafka ah 2-4 maalmood intravenously in dadka waaweyn ee 200-300 mg 24 saacadood ee kasta, ka dib markii taas loo isticmaalo qaab irbado duridda at dose oo ah 100 mg ah saddex jeer maalintii. Xaaladdan oo kale, muddada daaweynta ay gaari karaan afar iyo toban maalmood.

Haddii ay tahay dhaawac cranial ama saamaynta ay kala duwan, daroogada loo isticmaalo 10-15 maalmood lagu duro xididka in mugga a of 200 500 mg 2-4 jeer maalintii.

Diyaarinta "Armadin" (irbadaha) maamulay la encephalopathy vascular decompensated halkaas oo intravenously waxaa loo isticmaalaa by duro faleebo ee qiyaasood oo 100 mg laba ama saddex jeer maalintii muddo 14 maalmood ah, ka dib markii taas oo intramuscularly waxaa loo isticmaalaa laba toddobaad at 100 mg laba jeer maalintii. Intaa waxaa dheer, daroogada waxaa loo isticmaalaa in nidaamka iyo ka hortagga dabcan encephalopathy vascular in dadka waaweyn ee maamulka muruqyada dhexdooda of 100 mg laba jeer maalintii muddo ah laga bilaabo 10 ilaa 14 maalmood.

Wadnaxanuun myocardial infarction

Haddii bukaanka gaaray Wadnaxanuun ba'an myocardial, kiiskan, daroogada "Armadin" (shots) intramuscularly ama faleebo lagu duraa 14 maalmood iyada oo therapy caadiga ah, oo ay ku jiraan dhammaan noocyada thrombolytics, celiyeyaasha ACE, Astaamaha, antiplatelet iyo wakiilada xinjirowga, iyo sidoo kale Nitrate. Shantii maalmood ee ugu horeysay ee ay la isticmaalo si loo gaaro saamaynta ugu badan ee suurtogalka ah, waxaa lagu talinayaa in la isticmaalo qalab ah intravenously. Intii lagu guda jiray sagaalkii maalmood ee soo socda hore u bixisaa maamulka muruqyada dhexdooda.

Maamulka xididka waxaa lagu fuliyaa by galiyey faleebo, iyo daroogada this waa in lagu maamulo si tartiib ah si ay u la baabi'iyo khatarta waxyeellooyinka. medicament loo isticmaalo in 0.9% xal sodium chloride ama 5% xal dextrose mugga ah oo ku saabsan 100-150 ml. hordhaca ah waxaa lagu fuliyaa for 30-90 daqiiqo. Haddii loo baahdo, daroogada "Armadin" (irbadaha) maamula bolusdose gaabis ah ugu yaraan 5 daqiiqo.

Wakiilka waa in lagu maamulo saddex jeer maalintii 8 saacadood kasta saacadood kasta. Qiyaasta maalin walba daweyn, haddii ay taasi u dhaxeysa 6 ilaa 9 mg halkii kiilo ah oo miisaankeedu yahay jirka bukaanka, iyo qiyaasta hal ka mid ah, siday u kala horreeyaan, 2.3 mg / kg miisaankiisa jirka. Ugu badnaan dose maalin walba suurtagal tahay 800 mg, halka-mar ka mid ah lagu taliyay in la maamulo wax ka badan 250 mg.

cudurada kale ee

In joogitaanka khamriga syndrome absinentnogo daroogada la maamulo ee dose oo ah 100-200 mg intramuscularly laba ama saddex jeer maalintii, ama waxaa loo isticmaali karaa faleebo xididka 1-2 jeer maalintii for 5-7 maalmood, sida ka muuqata hab "Armadin" User codsiga (irbadaha). Reviews dhakhtarrada ayaa sidoo kale soo jeedinaya in ay goobjoog ka ahaayeen nooca daawooyinka sarkhaan ba'an daroogada waa in la maamulo intravenously kaliya ee qiyaasood oo laga bilaabo 50 mg ilaa 300 mg maalin kasta 7-14 maalmood.

Haddii ay jirto hababka wax bararka ee hab saabka caloosha waxaa loo xilsaaray sida lamaguraan a maalinteedii kowaad, ka dibna - sida therapy postoperative. Xaaladdan oo kale, qiyaasta toos ah ku xirnaan doontaa cudurka darnaanta iyo foomamka kacay, dabcan kiliinikada iyo geedi socodka faafinta. Waa in la ogaadaa in haddii loo baahdo, ka qaato daroogada taas waa in la sameeyaa si tartiib tartiib ah, oo kaliya ka dib marka la gaari saamaynta caafimaad iyo shaybaar joogto ah wanaagsan.

Marka an medicament pankreatit edematous ba'an waxaa loo isticmaalaa in dose of 100 mg saddex jeer maalintii intravenously ama intramuscularly ku xiran reading dhakhtarka.

ganaaxyada

fiiro gaar ah waa in la siiyaa magacaabidda daroogada si uu bukaan isagoo taariikhda xasaasiyad. Mararka qaarkood, dadka qaba xiiqda in joogitaanka dareen xad-dhaaf ah si ay u sulphate laga dheehan karo horumarinta reactions diidmo daran. Ka dib markii dhamaystiri doono maamulka parenteral, si ay u ilaaliyaan saamaynta gaari waxaa lagu dhiirigelinayaa in ay sii wadaan isticmaalka qalab gudaha ah oo ah qaab kiniin.

Waxaa jira baaritaano caafimaad oo no si fiican loo koontaroolay ku saabsan ammaanka xarunta this at dhaweyn inta lagu jiro nuujinta ama uurka looma fuliyo, sidaa awgeed dhakhaatiirta ma ku talinaynaa u isticmaalaya in muddo this. Sidoo kale, waxbarashada ayaa la sameeyay oo ku saabsan ammaanka daroogada ee ay la isticmaalo oo lagu daweeyo carruurta oo xidhiidh la leh waxa loogu talagalay waxaa sidoo kale aan lagu talinayaa in ay la isticmaalo, xataa haddii ay dhacdo cudurada ogalayn in.

Intaa waxaa dheer, waxaa xusid mudan in in koorsada daawada loo baahan yahay in ay gutaan taxaddaraan marka ay baabuur-wadidda baabuurta ama habab kala duwan, sida ka muuqata hab tilmaamo "Armadin" loo isticmaalo (irbadaha). Analogs daroogada oo inta badan ku kala duwan yihiin waxyeelo la mid ah. Tani, tusaale ahaan, sida "Meksidol", "Mexicor", "Meksifin", "Neurox".

Iyada oo la isticmaalo daba dheeraaday ee medicament ku tilmaamay muujin karaa tiro cayiman oo waxyeelo, oo ay ku jirto daal, dibiro ama barar durugsan. Marka intravenously maamulo (waxay khuseysaa gaar ahaan jet) ayaa u muuqan kara dhadhan macdan ah oo afka, dhuun xanuun, dareenka kulaylka jidhka, uurkuna waa, tachycardia oo dhan, bafinayo ee wajiga iyo tiro ka mid ah saamaynta kale, kaas oo la xidhiidha duritaanka xawaare aad u sareeya "Armadin" ( irbado). Reviews soo jeedinaynaa in saameyn taas ay muddo kooban ah.