Beta-agonister: description, liiska tallaabo daroogada

daroogada kasta loola jeedaa koox pharmacological qaarkood. Taas macnaheedu waa in daawooyinka qaar ka mid ah waxay leeyihiin hab la mid ah garoomada, tilmaamo iyo waxyeelo. Mid ka mid ah kooxaha ugu waaweyn ee dawooyinka - taasi waa a agonister beta-adrenergic. Daawooyinkan waxaa hubkaas ayaa loo isticmaalaa in lagu daaweeyo heley neefsashada iyo wadnaha.

Waa maxay In-agonister?

Beta-agonister - Koox ka mid ah qalabka caafimaadka loo isticmaalo in lagu daaweeyo cudurro kala duwan. In jidhka, Waxay isku xidhxidhaan si receptors gaar ah oo ku yaalla muruqa siman oo ka mid ah unugyada hawomareenno, ilmo galeenka, wadnaha iyo xididdada dhiigga. dhexgalka noocan oo kale ah waxay keentaa in kicinta ah ee unugyada beta ah. Sidaas darteed of hawshooda u ah ee geedi socodka nafeedba u kala duwan. Marka qabanaya of B-agonister in receptors wuxuu kobciyaa soo saarka ee wakiilada noolaha, sida dopamine iyo adrenaline. waa magac kale oo ah waxyaalahan - beta-agonister. saamaynta Major dhanba - xawaaraha ah garaaca wadnaha, cadaadiska dhiigga oo kordhay iyo in la wanaajiyo conductivity bronki.

Beta-agonister: ficilka ah ee jirka ku

Beta-agonister kala qaybsan yihiin V1- iyo agonister B2-adrenergic. Dhaweeyayaasha for walxaha kuwanu waa in ay xubnaha gudaha. Marka qabanaya in beta-agonister ay keeni hawshooda u ah ee geedi socodka badan ee jirka ku jira. Waxaa jira saamaynta soo socda ee B-agonister:

1. Kordhinta automaticity wadnaha iyo horumar conductivity.
2. garaaca wadnaha oo kordha.
3. Acceleration of lipolysis. In la isticmaalo, B1-agonister muuqan in acids ee dufanka dhiigga oo lacag la'aan ah kuwaas oo ah wax soo saarka ee burbur ee triglycerides.
4. La kordhiyo cadaadiska dhiigga. saamayn Tan waxa u sabab kicinta ee habka renin-angiotensin-aldosterone (Raas).

Si aad u isbedel ku qoran ee jirka ku keenaysaa in ku qabanaya of agonister receptors B1. Waxay ku yaalaan ee muruqa wadnaha, xididdada dhiigga, unugyada adipose iyo hay'adaha juxtaglomerular unugyada kelyaha.

receptors B2 ku yaalaan hawomareenno, ilmo galeenka, murqaha lafaha, habka dhexe ee neerfayaasha. Intaa waxaa dheer, ay yihiin wadnaha iyo xididada dhiiga. Beta-2-agonister keeni saamaynta soo socda:

1. Horumarinta ee conductivity bronki. saamayn Tan waxa u sabab nasashada ee muruqyada siman.
2. Acceleration of glycogenolysis ee muruqyada. Sidaas darteed of murqaha lafaha dhakhso badan oo la dhimay.
3. nasashada ee myometrium ah.
4. glycogenolysis dardargelinta in unugyada beerka. Tani waxay keenaysaa in kordhay heerka sonkorta dhiigga.
5. garaaca wadnaha oo kordha.

Waa maxay daawooyinka waa koox ka mid ah B-agonister?

Dhakhaatiirta badanaa qori beta-agonister. Daawooyinka ka tirsan kooxdan pharmacological, qaybsan daawooyinka gaaban oo degdeg ah-simaha. Intaa waxaa dheer, daroogada go'doon leeyihiin saamayn doorashada xubnaha qaarkood oo keliya. Daawooyinka qaarkood ayaa si toos ah u dhaqmaan on the V1- iyo V2-receptors. Daawooyinka-ugu wanaagsan ee loo yaqaan ka tirsan ee beta-agonister jira daawooyin "salbutamol", "fenoterol", "dopamine". agonister The isticmaalo in lagu daaweeyo cudurrada sambabada iyo wadnaha. Sidoo kale qaar ka mid ah iyaga ka mid ah waxaa loo isticmaalaa in shuruudaha qaybta daryeelka degdegga ah (daroogada "Dobutamine"). daawooyinka ka yar caadiga ah ee kooxdan waxaa loo isticmaalaa in ku dhaqanka dumarka.

Qoondaynta oo ah beta-agonister: noocyo ka mid ah daawooyinka

Beta-agonister - kooxdan pharmacological, oo ay ku jiraan tiro badan oo ah dawooyinka. Sidaa darteed, waxay u qaybsan yihiin kooxo dhowr ah. Qoondaynta B-agonister ka mid ah:

1. Non-xushay agonister beta-adrenergic. Kooxdan waxaa ka mid ah daroogada "ortsiprenalina" iyo "Isoprenaline".
2. Selective B1-agonister. Waxay waxaa loo isticmaalaa in cudurada wadnaha iyo qaybaha daryeelka degdegga ah. Wakiilada ee kooxdan oo ah daroogada waa "Dobutamine" iyo "dopamine".
3. beta-2-agonister Selective. Kooxdan waxaa ka mid ah daawooyinka loo isticmaalo cudurada nidaamka neef-mareenka. Taa baddalkeeda, agonist ka B2 xushay qaybsan daroogada ku-simaha-gaaban, iyo daroogada isagoo saamayn waara. Kooxdu waxay ugu horeysay ka mid ah daawooyinka "fenoterol", "terbutaline" "salbutamol" iyo "hexoprenaline". daroogada Long-simaha - daroogada ah "Formoterol", "Salmeterol" iyo "indacaterol."

Tilmaamayaasha In-agonister

Tilmaamayaasha in loo isticmaalo ee B-agonister ku xiran tahay nooca maandooriyaha. Beta-agonister waa tallaabo aan la xushay waxa ay hadda si dhib leh loo isticmaalo. Horaantii, ay isticmaalaa si loo daaweeyo noocyo ka mid ah garaaca, sii xumaanaysa tabinta wadnaha, neefta bronki. Haddaba dhakhaatiirta door bidaan in qori la xushay B-agonister. Ay faa'iido waa in ay haystaan waxyeelo yar. Intaa waxaa dheer, daroogada la xushay fudud si ay u isticmaalaan, sida saamayn kaliya xubnaha qaarkood.

Tilmaamayaasha for B1-agonister loogu tala galay:

1. wadnaha Ba'an.
2. lama filaan ah ee etiology kasta.
3. Dumaan.
4. cilladaha wadnaha decompensated.
5. Marar dhif ah - cudurada wadnaha ischaemic degree halis ah.

B2-agonister maamula in neefta bronki, chronic obstructive pulmonary disease. Xaaladaha intooda badan, daawooyinkaan waxaa loo isticmaalaa foomka of aerosols. Mararka qaarkood daawo "fenoterol" waxaa loo isticmaalaa in ku dhaqanka dumarka si aad u yarayso foosha, iyo ka hortagga dhicin. Xaaladdan oo kale, daroogada waxaa maamula intravenously.

Xaaladaha qaarkood, B-agonister yihiin?

Waa in la xusuustaa in kooxda daroogada A beta-agonister leeyihiin tiro ka mid ah sababo iyo waxyeelo. Tani waa run gaar ee agonister aan la xushay. Dhibaatooyinka ay keento daawooyinkan - .. Ma horumarinta hyperglycemia, gariir addinka, xanuunada garaaca wadnaha, dhexe nidaamka excitation neerfayaasha, iwm Beta-1 agonister jira daawooyin awood, sidaas darteed waxaa loo isticmaalaa oo kaliya in xaaladood oo deg-deg ah u baahan. Waxay yihiin in bukaanka qaba taariikh cudurada sida: arrhythmia ventricular, stenosis subaortic, pheochromocytoma. Sidoo kale, waxay ma loo isticmaali karaa tamponade wadnaha.

B2-agonister yihiin in arrimaha soo socda:

1. Dulqaad in beta-agonister.
2. Uurka adag by dhiig, abruption -balaasentaal abrabshan, hanjabay dhicin.
3. Carruurta ka yar 2 sano jir ah.
4. geeddi socodka bararka ee myocardium, garaaca wadnaha.
5. Diabetes mellitus.
6. stenosis Aortic.
7. Hypertension.
8. wadnaha Ba'an.
9. Thyrotoxicosis.

Medicament "salbutamol": tilmaamaha loo isticmaalo

Drug "salbutamol" waxa loola jeedaa B2-agonister garoomada ka gaaban. Waxa loo isticmaalaa in syndrome ee xirma bronki. Inta badan loo isticmaalo in aerosols 1-2 qaadasho (0.1-0.2 mg). Carruurta doorbiday in la sameeyo neefsasho ah via nebulizer ah. Waxaa sidoo kale jira qaab kiniin oo ah daawada ah. qiyaasta loogu talagalay dadka waaweyn waa 6-16 mg maalintii.

"Salbutamol": qiimaha daroogada

Daawada loo isticmaalo sida monotherapy in neefta fudud. Haddii bukaanku leeyahay stage dhexdhexaad ah ama daran cudurka, sii dheerayn daroogada codsatay (beta-agonister dheer-simaha). Waxay yihiin therapy aasaasiga ah ee neefta bronki. iyadoo la isticmaalayo "salbutamol" daroogada gargaarka deg deg ah ee weerarada ka mid ah neefsashada oo dhib. Qiimaha daroogada waa ka soo 50 ilaa 160 rubles ku xiran tahay soo saaraha iyo qiyaasta ku jira weelka.