"Azithromycin" ee carruurta, diiwaanka, dib u eegista

In case of cudurada adag oo aan xamili karo antibiotics ku salaysan penicillin, dhakhaatiirta qori "azithromycin". Waayo, carruurta (tilmaamaha loo isticmaalo waxaa loola jeedaa in ay) daroogada waxay leedahay saameyn aad u xoog badan, mararka qaarkood, carqaladeeyo kartaa weli ma si buuxda u sameeyay shaqeeyo, sidaa daraadeed waxa qaadan qiyaasood ugu yaraan loo baahan yahay.

foomka Release iyo halabuurka

Dejinteedu waxay ka kooban tahay oo ah walaxda firfircoon oo excipients kaabayaal azithromycin by kaas oo ku siin kiniin qaab dhaqanka. Sidoo kale in walxahan waxay mahad waxaa nuugo daroogada wanaagsan.

Sababo la antibiotic ah spectrum ballaadhan u isticmaalaan noocyada kala duwan ee sii daayo of daroogada loo isticmaalo Farmashiiste casriga ah:

• kaabsoosha oo habmaamulka adag jidh buluug dabool iyo buluug, gudaha taas oo ah cad ama midab huruud ah budada (ama tiro is dulfuulan). Marka aad riixdid nasashada. kaabsoosha waxaa ku jira Intaa waxaa dheer in ay qayb firfircoon, cellulose mikrokristallin, sodium lauryl sulfate iyo milmahayn magnesium.
• "Azithromycin" (125) tilmaamaha loo isticmaalo ee carruurta sharaxayaa sida film kiniinada buluug, qaab wareeg ah, biconcave. Dhinaca keliya bay leeyihiin xardho ah "PLIVA", oo dhinaca kale ah - "125". Haddii aad jebiso, waxaad ka arki kartaa in Warega of kaniiniga cad. Waxay ka kooban oo ka mid ah adjuvants soo socda: calcium ammooniya phosphate hydrogen, hypromellose, galleyda, cellulose mikrokristallin, istaarijka pregelatinized, sodium lauryl sulfate iyo milmahayn magnesium.
• Drug "azithromycin" ee carruurta barashada arjiga ku talinaysaa qaab ganaax ah, si farmashiyaha ka soo iibsan kartaa budo gaar ah diyaarintiisa la cherry ama muuska ur.

Qiimaha kordhay antibiotic ku xiran tahay content ee walax firfircoon.

sifooyinka pharmacological

"Azithromycin" waxa loola jeedaa ka antibiotics ballaaran spectrum. Marka uruureen sare ee diiradda caabuq dhacdaa dhimashada sheyga.

Inta badan xasaasi u garaam-positive cocci daroogada: Streptococcus pneumoniae, kooxaha Streptococcus CF iyo G, Staphylococcus aureus, St. Pyogenes, St. Viridans, St. agalactiae; Gram-negative bakteeriyada: catarrhalis Moraxella, H. Ducrei, Haemophilus influenzae, pneumophila Legionella, Bordetella pertussis, Neisseria gonorrhoeae, B. Parapertussis, Gardnerella vaginalis iyo Campylobacter jejuni; organisms anaerobic: trachomatis Chlamydia, bivius Bacteroides, urealyticum Ureaplasma, spp Peptostreptococcus, perfringens Clostridium, burgdoferi Borrelia, markii laysu tago laysu, iyo Mycoplasma pneumoniae. bakteeriyada Gram-positive adkaysi u erythromycin, antibiotic la isku beddelaysaa qaab aan firfircoonayn.

Pharmacokinetics

"Azithromycin" ee caruurta (tilmaamaha loo isticmaalo waxaa loola jeedaa in ay) si degdeg ah nuugo ka soo mareenka caloosha iyo mindhicirka ay sabab u tahay iska caabin ah si dhexdhexaad ah acidic iyo lipophilicity. Si degdeg ah loo qaybiyey jidhka oo dhan. Si fudud u guskiisa ma aha oo kaliya galay mareenka-mareenka, unugyada jilicsan iyo maqaarka, laakiin sidoo kale in xubnaha of mareenka Fistula. Sidaas darteed, a yar yahay waajib ah azithromycin iyo serum borotiinada, awoodda wax lays geliyey unugyada eukaryotic iyo ka-fiirsashada ee dhexdhexaad ah oo leh pH hooseeyo, lysosomes deegaanka kordhay muddo nus-nolosha iyo ka-fiirsashada ee unugyada.

All this go'aamiso mugga ugu sareeya ee qaybinta (31.1 litir kg) iyo ansixin plasma sare. Wixii burburinta wareer ah intracellular muhiimad badan waa karti "azithromycin" ururto si toos ah in lysosomes ah.

Sababo phagocytes daroogada helo goobta cudurka, halkaas oo uu ka sii daayay in habka of phagocytosis. Ka dib markii 12-72 saacadood oo qaadanaya diiradda caabuq waxaa lagu gaarayaa by-fiirsashada sare ee daroogada, taas oo si weyn u ka badan yahay fiirsashada ugu yaraan inhibitory infekshanka of wareer ah.

Sida hore u soo sheegnay, bar-nolosha geedi socodka dheer, sidaas darteed, tusaale ahaan, waxay u baahan yihiin 60 ilaa 76 saacadood in ay ka saarto ka difaan. fiirsashada Bactericidal ee daroogada waxa lagu kaydiyaa at sites barar 5-7 maalmood ka dib qiyaasta ee la soo dhaafay, sidaas waxaa suurtagal ah in ay isticmaalaan hal antibiotic ah maalinta, koorsada daawada waa in aan ka badnayn toddobaadkii.

Muujiya "azithromycin" inta badan in bile, iyo kaliya jajab yar - marka la kaadinayo.

Tilmaamayaasha gelitaanka

"Azithromycin" tilmaamaha loo isticmaalo ee carruurta waxaa lagu dhiirigelinayaa inay soo magacaabaan ee cudurada faafa iyo bararka, taas oo keentay bakteeriyada nugul azithromycin. cudurada noocan oo kale ah waxaa ka mid ah: pneumonia, boronkiitada, hogaga, pharyngitis, unugyada jilicsan iyo cudurada maqaarka, qumanka, otitis media, cudur ku faraxnay iyo urethritis. Waayo, takhaatiirta carruurta pneumonia looga shakisan yahay u muuqdaan in ay si dhakhso ah kuu qori antibiotics, xitaa iyada oo natiijada imtixaanka X-ray. Daaweynta cudurkan bilaabi waa in waqti wanaagsan, haddii kale aad la kulmi kartid cawaaqibka ugu nasiib darro. antibiotic The xaaladan oo kale la doorto iyada oo la tixgelinayo calaamadaha oo dhan, pathogene lagu soo eedeeyey iyo sawirka kiliinikada oo dhan. In la go'aaminayo u shaqeeyo keenaya cudurka, da'da ilmaha waa la tixgeliyaa. Haddii pneumonia lagu tuhunsan yahay in ilmaha ay da'doodu u dhaxayso 1 ilaa 6 bilood, ka dibna. u badan tahay, wakiilka - of Staphylococcus aureus, ka hal sano ilaa lix sano - Streptococcus pneumoniae. Iyadoo labada nooc oo bakteeriyada wax ku ool ah ku dagaalama "azithromycin".

Qadarka Qaadashada

daawada waxay ku xirnaan doontaa cudurka, laakiin qiyaasta guud waa in la dayactiro. Dhakhtarku wuxuu kuu qori karaa "azithromycin" daroogada ee carruurta. Tilmaamaha loogu isticmaalo fasaxa kiniiniyada in ay qaataan oo kaliya dadka waaweyn tan iyo markii ay ka kooban yihiin 250 500 mg oo ah walaxda firfircoon, iyo qadarka this waxaa loo xisaabiyaa on mass ah halkii ballaaran. Xaqiiqada ah in kiniiniyada in la wada liqo, laguma talinayo in ay burburin ama qaawi, sidaas awgeed si aan joogteyn karto qiyaasta lagula taliyey isticmaalka hal mar ah (10 mg / kg). Waa sababtaa tan aan dhallinyarada sida wakiilada bakteeriyada ay maamusho "azithromycin" (125). Tilmaamaha loogu isticmaalo ee carruurta kiniin mamnuucayaa qaato ilaa 12 sano, waxaa lagu bedeli karaa sharoobada ah ama ganaax ah.

Waayo, daawaynta cudurada ba'an bararka marinka hawada, otitis, pneumonia magacaabay dose daroogada hal (10 mg / kg). Drug "azithromycin" (125) tilmaamaha loo isticmaalo carruurta kiniin ku talinaysaa in kaliya ka dib 14 sano jir. Daaweynta Caruurta sameeyaa si gaar ah isticmaalaya slurry ah.

Waxaa la tilmaamayaa in 5 grams of sharoobada "Sumamed" (qaaddada shaaha) iyo samaynta kale analogs sidoo kale ku jira 125 mg oo ah walaxda firfircoon. Iyadoo la raacayo, qiyaasta caadiga ah ee carruurta waaweyn waa 1-2 qaado, taas oo ku xidhan miisaanka. Inta lagu guda jiro soo socda afar maalmood oo dawada ah sii, laakiin qiyaasta la mid ah waa la dhimay ilaa 5 mg / kg. In case of dose cudurka daran loo Laab laabi laga yaabaa, laakiin in xaaladda noocan oo kale ah, isticmaalka antibiotic la ogol yahay oo kaliya iyada oo ay kormeerayaan dhakhtar takhasus u leh. Diyaarinta "azithromycin" (125) tilmaamaha loo isticmaalo ee carruurta waxaa loo isticmaali karaa oo kaliya haddii ay dhacdo helo hal mar ama laba jeer at qiyaasta a of 30 mg / kg miisaankiisa jirka.

sababo

Drug "azithromycin" ee buuga carruurta barashada mamnuucayaa culeyskiisu yahay in ka yar shan kiiloogaraam. Intaa waxaa dheer, waxa waa u bukaanka qaba diidmo in qaybaha ku jira sideeda in wax antibiotics kale macrolide. daroogada Tani waa kiis kasta waa in aan la isticmaali ee beerka daran iyo kelyaha.

Iska badinta iyo kooxda saamaynta

Waayo, kuwa hooyooyinka kuwaas oo la isticmaalayo daawada "azithromycin" ee carruurta, tilmaamaha loo isticmaalo (Kurtumm bukaan oo ku saabsan isticmaalka antibiotics soo bandhigay in wax this) waxay bixisaa liiska waxyeelo. On qayb ka mid ah dhismaha nidaamka iyo dhiigga lymphatic laga yaabaa in trombotsipenii.

Bukaan-socodka colaad cad, fawdada ah, isku yaacsanaan iyo walwalka. Laga soo bilaabo habka dareemayaasha Dawakh, gariir, madax xanuun, somnolence, iyo xataa la suuxi doonaan. Marar dhif ah, daroogada sababa hurdo la'aan, daal, paresthesias, aragtida sidoo kale ugu rabshaysan tahay carafta fooxiinna iyo dhadhan.

Qabsiyada macrolides (group of daroogada, ku salaysan qaab-dhismeedka kiimikada kuwaas oo taag giraanta macrocyclic 14- ama 16-membered lactone la harta carbohydrate ku lifaaqan), kaas oo iska leh "azithromycin" keeni lumis maqal. Marar dhif ah, laakiin weli waxaa jira waxyeelo of qof dyspeptic iyo dareen diidmo oo xasaasiyadeed Cad.

"Azithromycin" edbinta ku saabsan codsiga ogol yahay carruurta in ay isticmaalaan, laakiin kids daroogada la qaadi karaa oo kaliya ee foomka of ganaax ah. Wixii kids ka weyn haboon iyo foomka kaabsal oo ah antibiotic ah. Ka hor inta codsanaya dawada, waxaad u baahan tahay si aad u hesho ogolaansho dhakhtar oo si taxadar leh u akhri tilmaamaha warqadda la socota.

About iska badiyo waxay muujin kartaa shuban, lumista maqalka ee ku meel gaar ah, lalabo iyo matag. In case of aad iyo aad u qaadasho lagu talinayo waa in isla markiiba lagu dhaqaa caloosha, ka dibna sii soco ilaa therapy astaamaha.

ganaaxyada

Isticmaalka "azithromycin" inta aad uurka leedahay waa mid aad loo baahnayn, laakiin la aqbali karo haddii aan macquul aheyn in la isticmaalo si loo caawiyo qof dumar (saamaynta daroogada ku saabsan horumarinta uurjiifka at 100% aan la bartay) ah. xilliga nuujinta waxay marka loo isticmaalo waqtiga daawaynta antibiotic in ay kala go'do naas-nuujinta.

Carruurta ka yar 12 sano waa ka fiican in la doorto analog ah "azithromycin".

Cabitaanka khamriga waxba uma dhimeyso tallaabada of daroogada, si kastaba ha ahaatee ay la isticmaalo waxaa darey cudur kasta. Sidaa darteed, xaddiga baabbi'iyey khamriga lagu talinayaa in la yareeyo si ay ugu badnaan, iyo xataa si fiican in la siiyo ilaa on daaweynta si buuxda.

isdhexgalka daroogada

Marka helo "azithromycin" la laabjeexa ah ay ku jiraan calcium, magnesium iyo aluminium, waxaa yaraysa nuugista ee antibiotic, oo sidaas daraaddeed, lagama maarmaan ah si ay u dhawraan bareeg 2-saac u dhexeeya qiyaasood oo ah daawooyinkan.

Farqiga ugu muhiimsan ee u dhexeeya daroogada si antibiotics kale macrolide - isgaarsiinta lahayn nidaamka cytochrome ah. Sidaa darteed, marka la "theophylline", "carbamazepine", "Digoxin", "terfenadine" iyo "triazolam" qaaday ayaa no dhexgalka.

Haddii daroogada loo isticmaalo la "warfarin", waxaa lagama maarmaan ah in lala socdo markii prothrombin ah.

Lincosamides yareeyo waxtarka ah antibiotic iyo chloramphenicol iyo tetracycline kordhay.

Xaaladaha iyo shuruudaha

antibiotic waa in lagu kaydiyaa meel carruurtu aanay gaarin at ilaa heerkulka ilaa 25 digrii ah. On nolosha shelf cadaymaha la heli karo si daroogada "azithromycin" (carruurta), buugan edbinta. eryiddu diyaariyey lagu kaydin karaa wax ka badan 5 maalmood, budada laftiisa - 2 sano, iyo kiniiniga iyo kaabsuullada - ilaa 3 sano.

Analogs iyo fikradaha dadka bukaanka ah

Kuwa isticmaalay "azithromycin" ee caruurta (tilmaamaha loo isticmaalo kaabsoosha waxaa laguma talinayo in ay qaataan in carruurta), bidix u eegista inta badan wanaagsan. Ka dib marka ugu horeeysa ee horumar la taaban karo go'doon ah antibiotic, sii horumarka.

By analogues daroogada waxaa ka mid ah "Azitsin", "Zomax," "Sumamed", "Azitral", "Azaks", "Zitroks" iyo kuwa kale.