"Levodopa / benserazide-Teva": tilmaamaha loo isticmaalo, analogs iyo dib u eegis

Maxaa bedeli karaa daroogada this sida "L-Dopa / benserazide"? Analogues ee dawada looga hadli doonaa goor dambe oo maqaalka. Waxaan sidoo kale soo bandhigi doona astaamaha pharmacological of this qalab, foomka of sii daayo, tilmaamo iyo hababka isticmaalka ay.

Form, halabuurka, baakadaha

medicament The "levodopa / benserazide-Teva", edbinta waxaa ku jira kartoon laga saaro qaab kiniin, baakadeeyey ee dhalooyinka of 30, 20, 60 ama 50 gogo '. walax ugu weyn ee levodopa daroogada iyo benserazide taag. Iyadoo la tixgelinayo qaybood oo dheeraad ah, ay ku jiraan: mannitol, phosphate calcium hydrogen (ammooniya), MCC, crospovidone, istaarijka galley pregelatinized, Silicon Kolloidol dioxide, K25 povidone, milmahayn magnesium, iyo xabagta a colorant cas ferric.

sifooyinka pharmacological

Diyaarinta "levodopa / benserazide" ka dhigan wakiilka weheliso antiparkinsonian oo ka mid ah in ay ka kooban inhibitor decarboxylase (durugsan) beduliyum acid iyo dopamine maamaan L-amino ah.

In parkinsonism, dopamine ayaa la sii daayay ka ganglia ee asalka in tiro ku filan. Its bedelka waxaa lagu fuliyaa by helaya levodopa, taas oo maamaan ah dheefshiidka ee dopamine.

Qaybta ugu weyn ee element this ee unugyada durugsan waxaa lagu beddelay dopamine, oo aan ka qayb saamaynta antiparkinsonian, tan iyo ma aysan gelin iyada oo caqabad dhiig-maskaxda, iyo sidoo kale mas'uul ka yahay inta badan dhibaato.

The kinetics daroogada

Sida khubarada sifaha daroogada ee su'aasha, ama halkii, ay ogeed-habka? Levodopa la benserazide nuugo inta badan ku jira xiidmaha yar. Marka la helo daroogada gudaha fiirsashada peak la gaaro in ku saabsan 65 daqiiqo.

Waa in la ogaadaa in si gaar ah nuugo walxahaasi ku xiran tahay tilmaamayaasha pH intragastric, iyo sidoo kale heerka of Digo ku jira gastric.

Marka la helo levodopa isla markiiba ka dib cuntada ay fiirsashada ugu sareeya ee plasma waa saabsan 30% ka yar, iyo heerka uu gaarsiisan yahay nuugista - 15% ka hooseeya.

In u tiro badan, daroogada this waxaa laga helaa xiidmaha yar-yar, kelyaha, iyo beerka. Si kastaba ha ahaatee, kaliya 1% galo maskaxda.

bar-nolosha ee daroogada hoos u eegid, waqtiga waa saddex saacadood.

Si ka duwan levodopa, dejinta qayb ka ah sida benserazide, ma geli BBB ah. walax Tan waxaa u ururay ee unugyada sambabada, kelyaha, beerka iyo xiidmaha yar-yar.

Marka ay maamusho?

Drug "Levodopa / benserazide" waa anti-Parkinsonistic. Sidaa darteed, waxaa lagu talinayaa in uu magacaabo:

• syndrome parkinsonian (marka laga reebo syndrome waxaa keena daroogada ee waallida dajiya);
• cudurka Parkinson,
• baaxaa lugaha syndrome, oo ay ku jiraan dadka qaba kelyaha chronic ku jira dialysis.

Oo mamnuucday isticmaalka

Haddii ay jiraan sababo in daroogada "Levodopa / benserazide-Teva" (jawaabaha oo muujinaysa in ay ansax, aan hoos ka fiirso)? daroogada waxaa ka mamnuuc ah in uu magacaabo:

• cudurka maskaxda;
• diidmo in xubno wakiilada;
• rabshooyin halis ah in nidaamka hormoonada jidhka, iyo sidoo kale weelal iyo wadnaha;
• cudurrada oo ka mid ah kelyaha iyo beerka, laakiin horumarka ee baaxaa lugaha syndrome la dialysis dhalidda isku daro,
• nuujinta,
• glaucoma xiro;
• codsiga barbar inhibitors nonselective MAO;
• uurka;
• da'doodu ka yar tahay 25 sano,
• da'da taranka ee jinsi ah caddaallad ah, ma la isticmaalayo habab lagu kalsoonaan karo ee ka hortagga uurka.

"Levodopa / benserazide": Magaca ganacsiga, habka codsiga

Iibso tixgelin medicament noqon kartaa farmashiyada. Magaca ganacsiga daroogada u muuqataa sidii "Levodopa / benserazide-Teva".

In waxa qiyaasta maamula in bukaanka dawada loo arkaa? Daaweynta hab kuwaas bilaabo qiyaas yar yahay, oo waxaa si tartiib ah kor u kacay (waayo, qof kasta oo si gaar ah).

Sida laga soo xigtay khubaro ah, waa inaad ka fogaataa qaadasho sare ee daroogada this. The mudada kacmaha soo socda waa in la tixgeliyaa sida talo guud.

"Levodopa / benserazide", afka laga qaato ugu yaraan nus saac ka hor ama 65 daqiiqo cuntada ka dib ka dib.

Dadka hore u qaadan taasi ka dhigan tahay, bilowga ah ee daaweynta ku talinaynaa isticmaalka 12.5 / 50 levodopa mg oo benserazide afar jeer maalintii. Iyada oo tolerability wanaagsan ee qiyaasta uu u kordhey inta la mid ah saddex maalmood oo kasta. titration Xiga waxaa lagu fuliyaa la soo noqnoqoshada ah 1 30 maalmood oo kasta.

Caadi ahaan, saamaynta ay ku daweyn ka dib markii maamulka daroogada hore u arkay marka la helo 100 benserazide mg oo 400 mg ah levodopa maalin kasta.

qiyaasta ugu badan ee daawada maalin kasta waa 800/200 mg ah levodopa iyo benserazide siday u kala horreeyaan. lacagta ayaa sheegay of medicament waa in la kala qaybiyey 4 jeer ama ka badan. Oo sidaasay loo qaybin waa in si ay u siiyaan bukaanka la saamaynta aan fiicnayn ku-daweyn.

Iyadoo horumarinta dhibaato waa in la kordhiyo qiyaasta ama joojiyaan, ama waxaa loo yareeyo.

mudada The qiyaasta of daroogada xaaladaha caafimaad oo gaar ah

Sidee baan u qaataa daawada "Levodopa / benserazide"? khubaro Guest sheegaan in bukaanka la kulma isbedbedelka motor daran, qiyaasta maalin kasta ee daawada waa in la qaybiyey in ka badan 4 gelitaanka.

In da 'weyn, la kordhiyo qiyaasta waa meel si tartiib tartiib ah u qaadan.

waayo-aragnimo ee daroogada ah ee carruurta iyo dhallinyarada waxaa ku koobnayn.

In cagaarshowga iyo renal failure dose medicament habayn loo baahan yahay.

Iyadoo horumarinta dhaqdhaqaaqyo iska dhaca, gaar ahaan marxaladaha ugu dambeeya ee daaweynta, waxaa lagu talinayaa in la yareeyo qiyaasta. Isla sidaas u dhaqmaan cawaaqib aan loo baahnayn ee CCC ah.

Calaamadaha badinta

Reception "Levodopa / benserazide" qaadasho sare ee daroogada, micne ah, kaas oo hoos lagu soo bandhigi doonaa, waxay keeni kartaa calaamadaha sida lallabo, aan joogto ahayn, dhaqdhaqaaq aan ikhtiyaarka lahayn ah nooca bahal ah, hurdo la'aan, matag, wareer. Sidoo kale waa in la ogaadaa in horumarinta calaamadaha sida loo dhigi karaa ugu wacan si ay u yareeyaan nuugista of daroogada ka soo xiidmaha.

Waayo, daaweynta ee xaaladaha tilmaamay therapy calaamadaha (daroogo antiarrhythmic qoray, analeptic neefsashada iyo neuroleptics), oo si joogto ah loola socdo hawlaha muhiimka ah ee jirka.

dhexgalka

Drug "Levodopa / benserazide" macaamila daawooyin kale sida soo socota:

• Qaadashada trihexyphenidyl yaraynaysaa heerka laakiin aan ilaa xadka ah nuugista levodopa.
• daroogada Antihypertensive, opioids, neuroleptics iyo alaabooyinka reserpine ah, joogsada in tallaabada of medicament ku tilmaamay.
• Codsiga la laabjeexa yaraynaysaa heerka uu nuugista ka dhigan tahay hoos tixgelin by 32%.
• Metoclopramide kordhiyaa heerka nuugista levodopa ah.
• pyridoxine Admission yaraynaysaa saamaynta daawada antiparkinsonian.
• Levodopa iyo benserazide looma isticmaali karo in lala non-xushay MAO.
• daroogada viewed potentiates tallaabada of sympathomimetic.
• Levodopa iyo benserazide daawooyin kale antiparkinsonian wanaajisaa saamaynta suurad wacan oo aan loo baahnayn.

macluumaad gaar ah

Ka hor inta aanad bilaabin qaadashada "Levodopa / benserazide" Waa in baaritaan buuxa oo caafimaad. Tan waxa u sabab xaqiiqada ah in ay jiraan tiro ka mid ah cudurada kuwaas oo isticmaalka qalab this si taxadir leh u daran waa in uu:

• ma ay joogaan therapy gulukooma xagal furan bilaabaan ilaa bogsiinta dhamaystiran oo bukaanka.
• Mamnuuc ah daroogada oo jir- burin "halothane", sida waxaa laga yaabaa in ay gacan horumarka ee neuroleptic syndrome malignant inta lagu jiro suuxinta guud.

Sidoo kale waa in la ogaadaa in bilowga ah ee uu daawo qaadashada oo xuduudaheedu nafsaaniga ah la bedeli karo by bukaanka. Marka tan la eego, in koorsada daawada waxaa loo baahan yahay in si joogto ah loo baaro si ay ula socdaan hawlaha saxda ah ee dhammaan xubnaha gudaha.

Dadka cudurka macaanka qaba waa in ay dhawr jeer maalintii si aad u hubiso sonkorta dhiigga.

Qiimaha daroogada iyo analogues / micne ah ay

Imisa daroogada this sida "L-Dopa / benserazide-Teva"? Qiimaha daroogada this ku xiran tahay tirada kaniiniyada halkii pack. Waxaa si caadi ah u dhaxeysa 600-1250 rubles.

Maxaa la oran karo waa in lagu badalo daroogada antiparkinsonian? Its analogues muhiimsan iyo micne ah waxaa ka mid ah habka soo socda: "Zimoks", "Duellin", "Isik," "Lac" "Dopar 275", "Carbidopa / Levodopa," "Sinemet", "Sindopa", "Tidomet", " Tremonorm ". Waa in la ogaadaa in si degdeg ah sifooyinka pharmacological iyo hababka isticmaalka daroogada, kuwaas oo ku kala duwan yihiin waxaa laga yaabaa in aad u ka kor ku xusan. Sidaa darteed, si ay u bedelo, "levodopa / benserazide-Teva" waa in kaliya talooyinka dhakhtarkaaga.

Jawaab-celinta waxtarka daawada

Waa wax qarsoodi ah cudurka Parkinson waa cudur aad u daran. Intaa waxaa dheer, waa xujo adag dadka buka iyo kuwa ay jecel yihiin.

Sida ay ku takhasusay oo macaamiisha lagu jiro daaweynta daroogada this saameeyaa dhammaan bukaanada kala duwan. Mararka qaarkood xitaa iyada oo ay kormeerayaan adag dhakhtar la soo dhaweynta dheer oo kiniin ah waxaa lagu arkay bukaanka caro aadanaha iyo joog- gardarada. Sidoo kale, reactions dhinaca dhacaan sida muuq iyo wareer.

By yareynta qiyaasta in bukaanka qaar ka mid ah astaamaha xanuunada maskaxda iyo baaba ', halka shaqo motor aan si daciif ah. Si kastaba ha ahaatee, in bukaanka kale, xitaa ka dib markii joojiyo dhamaystiran oo daroogada oo dhan xanuunada maskaxda ku adkaystaan. Intaa waxaa dheer, shaqo motor ay si weyn u sii xumaado.

In la xidhiidha kor ku xusan oo dhan, waxaan si ammaan ah gabagabayn kartaa in soo dhaweynta ah ee lacagta loo baahan yahay in loo diyaar garoobo horumarinta waxyeellooyin ba'an, sida kor ku xusan.

Sida ay sheegayaan warar ka mid ah khubarada, habka daaweynta ee diyaarinta anti-Parkinsonistic waa inay qaataan meel kaliya iyada oo ay kormeerayaan adag ee dhakhtar. Tani waxay u ogolaaneysaa xitaa ay ula socdaan isbedelka daqiiqadii xaalad bukaan-socodka nidaamka wadnaha iyo soo gunaanadeen, iyo haddii loo baahdo - in fal hab wakhti.