Interferon aadanaha - guryaha noolaha

Interferon aadanaha la ogaadey 1957 by laba cilmibaadhe oo Isaacs iyo Lindemann. Thanks to soo saar this hab cusub oo loogu talagalay ilaalinta gacanta aadanaha ayaa la aasaasay cudurada viral. qorayaasha fayraska hargabka Heat-daarnayn ayaa samayisma in ukunta, horionalantois Hda iyo ogaaday in supernatant ah uu hakiyo koritaanka virus firfircoon on horionalantoise. factor A ahayd oo homogenates ah ayaa loo magacaabay interferon, iyo hantidiisa noolaha sanado badan u gaar ah la rumeysan yahay ilaalinta antivovirusnuyu. Waxa la ogaaday in soo saarayaasha ee interferon yihiin unugyada kala duwan ee unugyada dadka iyo xoolaha. Its formation waxaa laaluusheen by fayrasyada, bakteeriyada xoogaa yar, fangaska pathogenic, protozoa, saamayn mitogens polymers dardaro. Leukocytes ay awoodaan in ay u abaari Avv interferon in 3-4 saacadood ka dib markii cudurku virus.

Waa in la ogaadaa in arrin ku faragelin viral ayaa muddo dheer la yaqaan. Waxay ku salaysan tahay awoodaha ilaalinta aadanaha ka dhanka ah tallaabada of fayras jaahilnimadii iyadoo la kaashanayo arrimo iska caabin nonspecific, virus haddii waqti isku mid ah ama hore ee jirka isla helo khatar yar. Wax sidan oo kale, in uu yahay, arrin ku faragelin lagu arkay ka mid wareer ah bakteeriyada in koorsada ee ay is dhexgalka. Waxa la ogaaday in mid ka mid ah noocyada of pathogene joogsada kartaa dhalmo ee noocyada kale, oo sidaas beddelo koorsada la micneeyey si dadku cudurka. Waxaa caddeeyeen in marka qof qaba cudurka ama brucellosis xoolaha, waxay yeeshaan difaac anthrax. faragelin ku tilmaamay dhexeeya bakteeriyada brucella iyo tulariimiya. Waxaa jirta sabab u maleeyaan in faragelinta bakteeriyada soo saaray inhibitor in blocks unugyada dareenka ee-shaqeeyo Dhaqale in abuuraa xaalad allifey oo loogu talagalay jiritaanka mid ka mid ah jirooyinka tartamaya.

Sida laga soo xigtay xogta la soo dhaafay, waxaa jira saddex nooc oo interferon (gamma-difaaca, beta fibroblast iyo leukocyte Alfa interferon), taas oo ku kala duwan yihiin asal ahaan, jir ahaan iyo sifooyinka nafleyda. Waa in la sheegay in ay faragelin dhexeeya fayrusyada waxaa lagu fuliyaa iyadoo ay kaalmo ka mid ah inhibitor gaar ah oo uu ku dhexsameeysmo by unugyada shaqeeyo cudurka.

Caddeeyeen in interferon aadanaha - Koox ka mid ah peptides bayoloji firfircoon la xiriira, kaas oo loo sameeyay in unugyada ka dib markii kicinta by inducers kala duwan. fiirsashada ee interferon in uu awoodo in uu xakameeyo dhaqdhaqaaqa noolaha ee fayrusyada kala duwan ee jirka, kala duwan ilaa xad si xoog leh. Inta badan xasaasi u ah tallaabo ee interferon cadaato fayrusyada isagoo qaybaha qolof iyo egyahay dibadda ah (miksovirusy, arboviruses, fayraska furuqa), iyo picornaviruses halka adenoviruses wax garad baqshadda dibadda badan yihiin adkaysi u factor this. Si kastaba ha ahaatee, waxaa ka reeban marka fayrusyada isagoo baqshadda this, soo bandhigid kordheen caabiga tallaabo ee interferon (fayraska herpes).

interferon aadanaha

wadadii ugu weyn ee ay formation badan oo ka fiirsada wax lays ee unugyada acid nucleic shisheeye, kuwaas oo ku xad-dheelitirka caadiga ah hidaha ee kooxaha kala duwan ee unugyada. Wax kicinaya si fiican u qabtaan virus acid nucleic unugyada xayawaanka laf, inkasta oo kale acids nucleic uma shaqayn karo sidii inducers ee interferon. Waxaa ka mid ah qaybaha unugyada microbial in waxaa lagu gartaa saamaynta interferon, door muhiim ah waxaa ciyaaray by endotoxins bakteeriyada garaam-negative iyo sidoo kale lipopolysaccharides iyo polysaccharides, in pirogenal gaar ah, prodigiozan. Interferon waxaa soo saaray waxqabadka aadanaha sarkhaansan phages RNA iyo fayrasyada, taas oo ay si fiican u ilaaliyo saamaynta inhibitory of ribonuclease.

Iyadoo la tixgelinayo sifooyinka interferon, uu, in la barbardhigo inhibitors ee loo yaqaan simaha on virus si toos ah iyaga saamayn ku dhex unugyada xasaasi ah, iyaga adkaysi u dhalmo viral. Si interferon sheegi karin saameynta fayruska, unugyada xasaasi ah waa in ay Avv loo igmaday ee RNA gacanta iyo borotiinada gacanta.

Recently, sida wakiilka fayruska maamulo "aadanaha recombinant interferon Alfa 2". hab tallaabo fayruska la xiriira abuuritaanka nidaamyo ilaaliya neinfetsirovanyh virus unugyada. Tani waxay beddeshay guryaha ee xuubka unug, taasoo ka hortagaysa in wax lays ee virus galay gacanta.

The guryaha noolaha ka mid ah interferon cayimayo noocyada, taas oo macnaheedu yahay muujinta la xushay ee dhaqdhaqaada ee jirka ka mid ah noocyada ay homologous. Tusaale ahaan, interferon soo saaray unugyada embriyaha digaag, waxaa laga yaabaa in aan ilaaliyo jiirka ama nuujiya kale, iyo interferon soo saaray leukocytes aadanaha, ayaa hawl lahayn ee xayawaanka. hantida ma aha mid sugan iyo, mararka qaarkood, asal heterologous interferon laga yaabaa firfircoon ee jirka ka mid ah noocyada kale.