"Dichloroacetate Sodium": Halabuurka, fikradaha iyo tilmaamaha loo isticmaalo

Thanks to saynisyahano ah oo ka tirsan jaamacadda xarunta Alberta ayaa la Been abuurtay in Kanada, adkaadeen kansarka. Waxa kaliya ee looga gudbi karo by dardargelinta cudurka mitochondrial ayaa la baabi'iyay. daroogada abuurtay "dichloroacetate sodium," sida ay saynisyahano ah, si ay ula qabsadaan dhibaatadan oo la dhibtoonayo noocyo badan oo kansar ah.

sumadda daroogada Gaar ahaan wax ku ool ah ee dagaalka ka dhanka ah kansarka sambabada, maskaxda iyo xabadka. Back ee 30meeyada ee qarnigii labaatanaad, saynisyahano ku soo gabagabeeyey in aan caadi ahayn functional of unugyada mitochondria dawadda kansarka. Mitochondria waa organelles lagama maarmaanka ah ee gacanta ku nool, oo ilaa dhawaan, saynisyahano rumeysan yahay in ay u halligmaan - ma aha sabab kansarka, iyo natiijada. Sidaa darteed, tan iyo 2005 Michelakis shakisan la xiqiijiyay in this, imtixaanka bilaabay shaqo ku saabsan u taagoo of dichloroacetate sodium.

waxbarashada Laboratory daroogada

baaritaan sheybaar iyo baaritaan ku saabsan xayawaanka waxay muujiyeen in daroogada "dichloroacetate sodium" waa activator ah ensaymes mitochondrial in ay u dhigan waayo cudurada qaar ka mid ah iyadoo aan loo eegin nooca kansarka. Dhimista ka mid ah unugyada kansarka waxaa lagu gaarayaa by caadi hawlaha organelles. Daawada waa si weyn u kala duwan ka chemotherapy ee aan ahayn sun ah oo aanu u dhaqmaan ma oppressively on unugyada caafimaadka bukaanka.

Professor Michelakis baaqaday in miday walax ku jira sheyga, waxay suuro gelineysaa in la noocyada ugu badan ee kansarka ka qaban, marka laga reebo sarcomas. Daawada saamayn ku saabsan waxbarashada kansarka, taas oo aan la saamayn kara daawooyin kale. maalkiisu daroogada uusan ka tirsan mid ka mid ah shirkadaha dawooyinka ee hadda jira, si daroogada ma aha patent. Tani waxay si weyn u saameeyeen uu awood.

tijaabooyin shaybaadh muujisay in daroogada, haya'ad saamaynta gacanta on unugyada kansarka oo aan saamayn caafimaad waqti isku mid ah oo ku saabsan qaybo ka mid ah jidhka.

Marka si ay u bilaabaan qaadashada daroogada?

Waa arrin aad u muhiim ah in daaweyn jiray kansarka waxay ka dhigan tahay "dichloroacetate Sodium" marka xaaladda jirka weli waa lagu qanci karo. Ha sugin marinka dhowr saf oo chemotherapy, taas oo uu leeyahay halligaad weyn. Intaa waxaa dheer, unugyada kansarka u muuqdaan in ay horumariyaan difaac kiimikada. Waxa ay muddo dheer ahayd dhakhaatiirta Ogaaday. Koorsooyinka yar oo chemotherapy ugu horeysay sameeyey leeyihiin saamayn togan ku koorsada cudurka, ku xiga, on lid ku ah, ma yeeshaan. Sidaa darteed, daroogada waa in ay bilaabaan in ay qaataan sida ugu dhaqsaha badan, xitaa lala kooxihii chemistry. Si kastaba ha ahaatee, qiyaasta waa in aanay ka badnaan 15 mg halkii miisaanka 1 kg.

Diyaarinta "dichloroacetate sodium": Qaabkadhismeedka

Halabuurka The daroogada - cusbo sodium ee dichloroacetic acid ah. Sol waa samaynta a qaab laktosmonohydrat, taas oo ku saabsan 12% - .. Biyaha cad yihiin.

Seynisyahanno hadda ku howlantahay sidii si loo yareeyo sumoobo daroogada ee loo tixgeliyaa iyo waxtarka in dagaalka ka dhanka ah cudurka kansarka.

daroogada

Waxaa lagama maarmaan ah in la ogaado, haddii aad go'aansato in aad iibsato daawada "dichloroacetate sodium." Sida loo qaato daawada si ay u caawiyaan shaqeeyo jirran, saynisyahano horay u aqoonsaday. Iyada oo ku saleysan 1 kg ee miisaanka - 25-50 mg maalintii oo dhan. Isticmaalka daroogada muddo laba sano ah 50 mg keeni kartaa neuropathy durugsan, sidaas daraaddeed dose qiyaasta la dhimay ilaa 25 mg, kaas oo dalacsiiyay joojinta ifafaale xun.

Haddii daroogada ee qiyaasta ah 25 mg halkii 1 kg ee miisaanka keena saxarada, lalabo, kabuubyo in faraha, neefsashada oo dhib (waxa ay sidoo kale keeni kartaa niyad-jab, gariirka, dawakhaad, hurdo, kaadida oo soo noqnoqda, walwalka), qiyaasta waa in la hoos u dhigay miisaanka jidhka 10 mg halkii 1 kg . Mararka qaarkood ku talinaynaa in guud ahaan in ay joojiyaan qaadashada dhowr maalmood. Kolkaasuu mar kale loo baahan yahay inuu ku soo laabto dose isku mid ah - 25 mg halkii 1 kg ee miisaanka jidhka maalintii. Xaaladaha xusay of qaarna, taas oo uu bixiyo ifafaale hoos neuropathy durugsan ka dib markii la helo "sodium dichloroacetate" diyaarinta. Tilmaamaha isticmaali baahida loo qabo in lagu milo medicament ah loo tixgeliyaa biyo (100-150 ml). Tani waa fududahay in la sameeyo, tan iyo daroogada waa in budo ah. Waa in aad isku daydo in ay ka fogaadaan xiriirka maqaarka la sheyga - waxay keeni kartaa cuncun.

Isticmaal daroogada ee lysis ee burooyinka

daroogada waxay keeni kartaa lysis of burooyinka halista ah ee kansarka ba'an lymphatic, lymphoma non-Hodgkin, leukemia mielotsiticheskoy ba'an, kansarka naasaha, carcinoma cell, leukemia lymphatic chronic, kansarka Testicular, carcinoma cell, medulloblastoma.

Lysis burada malignant yeedhay apoptosis aad u deg deg ah ee unugyada kansarka (barnaamijkii dhimashada unugyada), oo ay la socdaan daraysa af gobolka ee caafimaadka (xaalado gaar ah, waxay keeni kartaa dhimasho). Xaaladaha noocaas ah, waa in aad isla markiiba joojin daawada oo la tasho dhakhtar. dhowr maalmood ka dib, laga yaabee, waxaa loo oggol yahay in ay dib u bilaabaan isticmaalka daroogada, halka yareynta dose.

Warbixin ku saabsan incompatibility daroogada waxaa loola jeedaa "dichloroacetate Sodium" daawooyin kale ma aha, sababta oo ah cibaaro (marka laga reebo - daawo "Lasix").

mar Isticmaal la shah kofeinizirovannymi, qaadasho sare oo fitamiin B1, isku darka ee qaarna, coenzymes Q, iyo Alfa-lipoic acid daray oggolyahay.

Saamayntii daroogada

medicament oggolyahay "sodium dichloroacetate" waxay ku xiran tahay dhawr arrimood. Si weyn u yaraynaysaa hantida ku daweynta ee xaaladda dadka saboolka ah ee bukaanka ah. Tusaale ahaan, markii ay sabab u tahay cudur saameeyeen xubnaha muhiimka ah waxaa, ama burburinta sarkhaansan chemotherapy dhacay. Sidoo kale, ha ku talinaynaa isticmaalka lacagta, haddii bukaanku uusan ku kici, si joogto ah u xanuunsan, ayuu qaadataa daawooyinka.

Waxay yaraynaysaa oolnimada oo ka mid ah diyaarinta iyo cudurka beerka guuldarro xoog leh. Marka ma awoodi karo in unugyada burada dhintay iyo waxyaabaha daatay dhaca dhiiga, xaaladda sii adag.

At waxtarka qiyaasta yar ee daawada ay yar tahay, marka natiijada dose waaweyn noqdo dareemi. Laakiin waxaa jira arrimo halis qaar ka mid ah. At qaadasho sare, waxaa dhici kara in alaabta suuska oo ka mid ah beerka buro lama qabsan karo. Tani waxay keeni doontaa sarkhaan, lalabo iyo matag. Sidaa darteed, qiyaasta waa in si sax ah u doortay.

Halkee si ay u iibsadaan?

Maxaa dhacaya haddii qof waa in ay iibsadaan daawada "sodium dichloroacetate"? Halkee si ay u iibsadaan? Available tixgeliyo daroogada ee Kanada, si aad u dalban karaa iyadoo la isticmaalayo khayraadka Internet ka soo saarayaasha ugu. Waxa kale oo jira waa fursad ay ku iibsadaan alaab daroogada ee Russia, si ay u soo iibsadaan Kanada. Qiimaha daawo ma aha sare, sidaa daraadeed waxa uu ka iibsan awoodi karin bukaan ka tirsan ayaa ceegaagta bulshada kala duwan.

Reviews of diyaarinta

Saamaynta wanaagsan ee daroogada "dichloroacetate sodium", kaas oo dib u eegis ku u xaqiijiyo, la ogan karo in badan oo qaba kansar. Daawada loo isticmaalo waqti isku mid ah oo la koorsada of chemotherapy, iyo daawooyinka kale ee aan hoos ku oolnimada. dhakhaatiirta Qaar ka mid ah oo aan rumaysan in dib u soo kabashada dadka bukaanka ah ay. Waxay ahaayeen yaabay markii bukaanka waxay ahaayeen gobalada dalka. dhibic badan oo ay ku la'aanta ah ee waxyeellooyin inta aad qaadanaysid daawada.

Faallooyin aan fiicanayn waa mid aad u yar. Kulligood waxay farta ku waxtardarradoodu ee daroogada "dichloroacetate sodium." Waa maxay? Waxaa la og yahay in bukaanka qaar ka mid ah daroogada ma caawin takhaluso cudurka. Dadka qaar ayaa xusay ah ee ku xoogeystay cudurka.

Sidee si loo xaqiijiyo siidaayay of daroogada

Xaqiiq tahay "dichloroacetate Sodium" daroogada waxay muujinayaan dhowr arrimood: waxa uu ka kooban yahay kiristaalo caddaan, dhadhan qadhaadh. Haddii midabka waa kiristaalo hurdi, medicament uu leeyahay tayo hooseeyo, iyo waxa aan la talinayaa. Marka go daroogada ee biyaha, waa in aan waayi dhadhan qadhaadh. Marka la badhxay in slurry budo yihiin xilliyo codsatay in ay maqaarka ka mid ah dhudhun ama dusha hoose oo garabka dura 1 daqiiqo inta lagu jiro 10 daqiiqo, ka dibna ka dib markii in muddo ah la qarka waxaa la aasaasay kaalinta unobtrusive. Oo 5-10 saacadood oo kaalinta ka dib wuxuu noqon doonaa dheeraad ah oo cas oo cad. dhowr maalmood at meeshan ka dib markii maqaarka uu bilaabo inuu dhil. Qaabkan ah xaqiijinta waxaa lagu talinayaa in la isticmaalo in kiiska xad dhaaf ah, isagoo intaa ku daray budada ah ee acid sulfuric loo isticmaalo gaadiidka batari, reaction kaaga horumar kulaylka iyo ur dichloroacetic acid. daawo Self ayaa ku dhowaad ma ur. The sare tayada daawada, ur yar. Haddii aad dhadhamin budada ah, waxaa ka dhigi doonaa kabuubyo, Nidhi Naaray iyo saamaynta tannic.