"Amphotericin B": waxbarida, hab ay of talaabo. Kurtumm ku saabsan daroogada

maqaarka fangas keeno raaxo badan bukaanka. Waxaa intaa dheer, cudurada faafa sida. Sidaa darteed, marka calaamadaha ugu horeeya ee fungus waa in ay daruuri tahay gudbiyo Takhtar Takhasus leh. Ka dib markii maraya tijaabada caafimaadka iyo baaritaanada kale dhakhtarku waxaa waajib ku ah in uu magacaabo a daawooyin wax ku ool ah bukaanka.

Inta badan, waayo, daawaynta cudurada fangas oo isticmaalaya noocyo kala duwan oo cadar iyo kiniiniga. Si kastaba ha ahaatee, dhakhaatiir badan ayaa sheegaya in xaalad cudur noocan oo kale ah waxaa ugu wanaagsan ee loola dhaqmo by duro xididka. Ka dib markii irbadaha daroogada isla markiiba bilaabaan inay u dhaqmaan on sheyga in muujiyaan dareen gaar ah, waxa uu.

Siyaabaha ugu hufan oo wax ku ool ah si ay u fuliyaan daawo si loo baabi'iyo cudurada fangas "Amphotericin B". Tilmaamaha, foomamka of sii daayo iyo Kurtumm ku saabsan daroogada waxaa lagu hoos lagu soo bandhigay.

Form, halabuurka, sharaxaad iyo baakadaha ah antibiotic

La helo tixgeliyo daroogada noqon kartaa foomamka soo socda:

• Lyophilisate "Amphotericin B". Reviews ayaa soo wariyay in foomkan of daroogada waa a mass furan hygroscopic midabka jaalaha ah oo aan lahayn ur fahmayaan. Waxaa loogu talagalay diyaarinta of xal galiyey. qayb firfircoon ee daroogada waa amphotericin B. qaybaha waxaa loo isticmaalaa sida walxaha kaabayaal sida monobasic phosphate sodium iyo deoxycholic acid. In iibinta medicament la bixisey in toddobada fijaan oo 10 ml, iyo waraaqaha kartoonada.

• Waxay cadarkan "Amphotericin B". Codsiga of hab this lagu muujiyay sida daroogada a dheeriga ah ee therapy isku dhafan. cadar Antifungal isticmaalo dibadda oo kaliya. Waa jaalaha ah iyo waxa ku jira qayb firfircoon ee isku magaca. Sida qaybaha dheeraad ah waxaa loo isticmaalaa sida saliid macdanta, petrolatum, iyo polysorbate 80. Buy daawo tani waxay noqon kartaa sanduuqa of 30 ama '15

hab ay of tallaabo of protivogribkvogo daroogada

Waa maxay daawada "Amphotericin B"? Tilmaamaha loogu isticmaalo (kiniin la qayb ka mid ah oo firfircoon helay arrin dhibaato) ayaa sheegay in ay tahay antibiotic ah macrocyclic polyene hawlaha antifungal. Waxaa la soo saaray Streptomyces nodosus, iyo waxay bixisaa fungistatic iyo ficil fungicidal (ku xiran tahay midda of daroogada dheecaanka nafleyda iyo nuglaato).

Ka dib markii daroogada galaya dhiigga waxaa xidhana in sterols in waxa laga helaa xuubka unug ka mid ah fangaska xasaasi u ah daroogada ah. Sidaas darteed gaadhista sida loo jeediyo permeability oo ay ka saareen qaybaha intracellular ka dhacaan meel bannaan oo extracellular.

Daawada waa "amphotericin B" waa firfircoon ka dhanka ah nooc badan oo dhexdhexaad ah firfircoon ka dhanka ah fangaska protozoa.

Sidoo kale waa in la ogaadaa in ay taasi ka dhigan tahay spp Fusarium u adkaysta. iyo Pseudallescheria boydii. Intaa waxaa dheer, daroogada tani ma aha wax ku ool ka dhanka ah rickettsiae, bakteeriyada iyo fayraska.

The guryaha ogeed daroogada

Haddaba aad u ogaato in uu yahay sida wakiilka antifungal ah, sida "Amphotericin B". hab ay of action ah wakiilka this ayaa kor lagu sharaxay.

Ka dib markii maamulka xididka of daroogada ee dose hal dhiigga isla markiiba abuuray ay fiirsashada wax ku ool ah oo la hayo maalintii oo dhan. borotiinada C xidhana in plasma qalab by 90 boqolkiiba.

medicament viewed qaybiyey beerka, sambabada, kelyaha, caajisnimo, murqaha, qanjirka adrenal iyo xubnaha kale iyo unugyada. Its fiirsashada ee effusion pleural, xuubka hoose iyo dheecaannada synovial iyo sidoo kale kaftan aqueous gaadho 2/3 fiirsashada ee dhiigga.

Taas macnaheedu waa dariiqa aan la garanayn. In kaadida iyo bile ah oo ku saabsan 98 boqolkiiba joogo daroogada ee foomka of metabolites ah. Soo bandhigay si tartiib ah iyada oo kelyaha. The bar-nolosha hore ee daroogada ee dadka waaweyn waa 24 saacadood, carruurta - 6-40 saacadood, iyo dhasha ah - 20-60 saacadood. Terminal bar-nolosha waa 15 maalmood.

Tilmaamayaasha antibiotic

Taas oo daawaynaya cudurada daawo "Amphotericin B"? Wuxuu ayaa loo magacaabay in horumar cudurada, naf-gooyada ah fangas in ay ahaayeen sababa sheyga nugul:

• histoplasmosis, cryptococcosis faafiyay, coccidioidomycosis;
• cryptococcal meningitis, paracoccidioidomycosis, chromomycosis;
• meningitis ay sababtay fangaska kale, blastomycosis American North;
• xadka- iyo aspergillosis invasive, phycomycosis (zygomycosis);
• sameeyaan gialogifomikoza candidiasis faafiyay,
• mycosis caaryada, mycetoma chronic;
• sporotrichosis faafiyay, cudurada caloosha (oo ay ku jiraan peritonitis);
• endophthalmitis, endocarditis, sepsis fangas;
• leishmaniasis visceral, cudurada kaadi mareenka fangas;
• leishmaniasis visceral cutaneous American.

Sababo wakiilka antifungal

Ka fikir waxa gobolka si aad u dalbato daroogada mamnuuc "Amphotericin B" (kiniiniga ka fungus ka mid ah magac la mid ah aan la soo saaray). Sida laga soo xigtay tilmaamaha, qalab this waa u:

• renal failure raaga,
• in diidmo;
• inta lagu jiro naas-nuujinta.

Iyada oo daryeel medicament firfircoon loo isticmaalaa in cudurka kelyaha (oo ay ku jiraan glomerulonephritis), amyloidosis, beerka cirrhosis, hepatitis, dhiig yari, Agranulocytosis, uurka iyo macaanka.

Lyophilisate "Amphotericin B": tilmaamaha loo isticmaalo

Wixii diyaarinta ah xal dawo xididka waxaa loo isticmaalaa la-fiirsashada hore of 5 mg / ml. Iyada oo sirinj 10 ml oo biyo nadiif ah la isku duro si ay u sameeyaan weelka la medicament ah. Next, waxyaabaha la gariiriyey si ay u sameeyaan dheecaan hufan Kolloidol.

daroogada xididka waxaa maamula saac gudahood ay gacanta ugu jiraan dhiig-karka, heerkulka jirka iyo garaaca wadnaha ee bukaanka. In ay daroogada dulqaad wanaagsan waxaa lagu talinayaa in qiyaasta maalinlaha ah ee 0.25-0.3 mg halkii kg miisaanka jidhka (ku xiran tahay darnaanta cudurka).

In cudurrada wadnaha iyo xididdada dhiigga, dareenka korodhay iyo shaqada kelyaha ku filnayn, daaweynta waxaa curin leh qaadashada yar (5-10 mg), kaas oo si tartiib ah kor u kacay 5-10 mg maalintii iyo waxa laga beddelo si 0.5-0.7 mg halkii kg.

Marka sporotrichosis daawo dose Dabcan waa 2.5 g, iyo muddada ka mid ah therapy - ugu yaraan 9 bilood.

Marka qiyaasta aspergillosis qalab uu yahay 3.6 g, iyo muddada daawaynta - ugu yaraan 11 bilood.

Ilmaha bilowga therapy maamula 0,25 mg halkii kg miisaankiisa jirka ah maalin kasta, ka dibna si tartiib ah kor u kacay qiyaas ugu badnaan (1 mg halkii kg).

Waxay cadarkan "Amphotericin B": tilmaamaha loo isticmaalo

Kiniiniyada ka yar isku magaca ganacsiga ee farmashiyayaasha aan la iibin. Sidaa darteed, in bedel lagu daawada waa in la tasho dhakhtar.

Haddii loo baahdo isticmaalka marisay "Amphotericin B" lakabka khafiifka ah waxaa laga codsadaa in meelaha ay dhibaatadu saameysey laba jeer maalintii. Dabcan daaweyn waxay ku xiran tahay cadeymaha la heli karo:

• la candidiasis ee laalaabka maqaarka - oo ku saabsan 1-3 toddobaad,
• la finanka xafaayadda carruurta - qiyaastii 7-14 maalmood;
• la paronychia iyo meelaha interdigital guuldarro - 2-4 todobaad.

waxyeellooyin

Diyaarinta "Amphotericin B" keeni karaan dhibaatooyinka soo socda:

• madax xanuun, suuxitaan, neuropathy durugsan, vertigo transient, encephalopathy;
• rabitaanka cuntada oo luma, matag, dyspepsia, lalabo, gastralgia, shuban, hepatotoxicity, beerku failure, cagaarshow, hepatitis, melena, caloosha iyo haemorrhagic;
• anemia normochromic normocytic, leukopenia, disorder xinjirowga, Torombositobiiniya, Agranulocytosis, anemia hemolytic, eosinophilia, leukocytosis;
• aragti cawlan, maqal la'aanta, diplopia, tinnitus,
• tachypnea, dyspnea, barar sambabada, arrhythmia iyo pneumonitis diidmo;
• hoos ama kor u kacay cadaadiska dhiigga, cuncun, isbeddel ah ee beegyada uu ECG, wadnaha oo shaqadiisa gaba, lama filaan ah, wadnaha oo shaqadiisa gaba,
• reactions anaphylactoid, hindhiso, Insipidus nephrogenic diabetes, bronchospasm, nephrocalcinosis, finan, dermatitis eksfoliativiy, necrolysis epidermal sun ah
• kelyaha, hypokalemia, gipostenuriyu, aysiidh embriyaha kelyaha, Stevens - Johnson syndrome, kelyaha ba'an, oliguria, anuria;
• thrombophlebitis iyo goobta la duray ugu dhex gubaan,
• qandho, myalgia, miisaanka oo yaraada, arthralgia, tabar guud.

xaaladood oo badinta

Marka ay maamusho qaadasho badan oo dawooyinka laga yaabaa in bukaan joojiyo neefsashada iyo wadnaha. Sidaa darteed, in koorsada of therapy waa in si adag u hoggaansamaan dhakhtarka qiyaasta lagu taliyey. Waxa kale oo lagama maarmaan ah si ay ula socdaan neefsashada iyo wadnaha, kelyaha iyo beerka shaqo, sawirka dhiiga durugsan, iyo sidoo kale ay ka kooban tahay ee electrolytes.

Waafaqsan yahay dawooyin kale

medicament The "Amphotericin B" xoojin karaa ama ufududeeyaan saamaynta maandooriyayaasha kale, iyo sidoo kale in la kordhiyo ay sumoobo. Sidaa darteed, daroogada taas waxaa loo qoray si taxadir leh in lagu daaweeyo.

In magacaabista Wakiilka ayaa sheegay in bukaan, hubi inaad soo sheegto dhakhtarkaaga ku saabsan qaadashada daawooyinka kale. Haddii kale, isticmaalka "Amphotericin B" (IV) dhaawici karta caafimaadka iyo guud ahaan fayo-qabka nin.

talooyin gaar ah

• Daawada waa "amphotericin B" waxaa loo isticmaali doonaa oo keliya oo lagu daweeyo cudurada naf-gooyada ah iyo fangas horusocod ah.
• Iyada oo la isticmaalo daba dheeraaday ee suurtagalnimada waxyeellooyinka sun kordhay.
• Marka isticmaalka daroogada waa in ay ahaataa anemia joojiyey.

Reviews

Haddaba aad u ogaato sida daroogada dhaqmo "Amphotericin B". joojinta la magac isku mid ma aha on sale in Farmasiiyada. Sidaa darteed, maamulka afka, waa in aad doorato daroogada kale oo talaabo la mid ah.

Sida ay inta badan bukaanada, loo arkaa adeegsanayo si waxtar leh ula qabsadaan hawsha. Waxaa si fiican ula dhaqmaan lesions maqaarka fangas, baabi'inta raaxo jireed iyo maskaxeed ee qofka bukaanka ah.

khasaare ugu weyn ee daroogada tani waa tiro badan oo ah waxyeelo. Inta lagu jiro daaweynta, this qalab dhibaato laga yaabaa inuu dhaco on qayb ka mid ah oo dhan xubnaha iyo nidaamka. Sidaa darteed, waa in la codsadaa oo keliya ee muujinaya gaar ah.