Alanine aminotransferase kordhay - calaamad u ah geedi socodka bararka iyo side in xubnaha

alanine Sababo la guuray NH2-kooxaha la deeq acid γ-amino ah in aqbalana ah - α-amino acid aan dhismaha dhexe ee ammonium. Taasi waa, transamination ah (transamination: iibsiga karo kooxaha amino in Keto acid) - geeddi-socodka ah u furay by saynisyahano Ruush caan ah iyo Kritsman Braunstein.

acids amino (aspartic, glutamic iyo aminotransferase) inta lagu jiro transamination beddelay dhiganta acid α-Keto ah, kuwaas oo qayb ka ah wareegga acid tricarboxylic. Inta lagu jiro ay qayilo in wareegga Krebs, oo iyagu waa il tamar.

Transamination waa lagama maarmaan in la siinayo wareegga HOL u aspartate.

In kasta oo xaqiiqda ah in dareen diidmo transamination ah loo soo bandhigin waxa laga yaabaa oo acids amino leedahay beduliyum: phenylalanine, tyrosine iyo tryptophan - codsi ku ool ah in daawooyinka ayaa laga helay qeexidda dhabta ah ee waxqabad ah ee aspartate iyo alanine aminotransferase. falgalka Kuwan waxaa si weyn loo qaybiyey unugyada jidhka bini'aadamka.

alanine aminotransferase kordhay unugyada dhiigga cas iyo ka-fiirsashada waa lix jeer marka la barbardhigo in serum dhiigga. tirada ugu badan ee eulayska go'an yahay in unugyada beerka.

caadi alanine aminotransferase ma aha isku mid u ah unugyada jirka aadanaha. Tusaale ahaan hawlaha enzyme in unugyada wadnaha waa 7.1 (E * 10-3 g homogenate tissue), beerka - 44, murqaha lafaha - 4,8, kelyaha - 19, beeryarada - 1.2, 0.7, iyo sambabada serum - 0,016. hababka jira ee go'aan ka soo baxay dhaqdhaqaaqa alanine ee serum waxaa loo qaybiyaa laba kooxood: endpoint ah (colorimetric, iyadoo la isticmaalayo caadiga ah, ma ku qalabeysan yahay heerkulka gacanta ku cuvette qalab photometric a) iyo ogeed (spectrophotometric).

B6 waa vitamin caadi ah in cuntooyin kala duwan. Si kastaba ha ahaatee, waa in la xusuustaa in inta lagu guda jiro habka cunto karinta (obrobka kaamerada) vitamin ee waa la wada baabbi'iyey. Pyridoxine waa cofactor ah falgalka ugu. Urursanaanta pirodoksin-5-phosphate in dhiigga hoos u da'da. Sidaa darteed, waxqabadka of enzyme tani waa alanine aminotransferase, hoos u dhacay dadka ka weyn 64 sano (30%) marka loo eego kuwa da'doodu u dhaxayso 46-63 sano. fiirsashada of vitamin B6 ee serum dhiig alanine aminotransferase sababaha.

Si loo go'aamiyo gobolka functional ah ee beerka waxaa inta badan baaro heerka alanine in dhiig bukaan-socodka. Tan waxa u sabab ugu horrayn si ay xaqiiqada ah in ay isbedesho in ay hawl dhacdaa ka dhakhso badan oo xuduudaheedu kale shaybaarka. Tirtiridda ah (Ka bixitaan) of falgalka beerka ee dhiigga ay calaamad u tahay of cytolysis - burburinta cell ama carqalad ah permeability xuub ay. Marka la falanqeeyo isbedelada in waxqabadka of falgalka muhiim ah in la dhiso meeshii reebay. Waxaad u baahan tahay in la ogaado ay waxqabad ee unugyada dhiigga iyo jirka caafimaad leh, deegaamaynta ah subcellular iyo dheef. fiirsashada enzyme The - aminotransferase kordhay, gaar ahaan unugyada beerka, sidaas darteed, xataa dhaawac yar si dhirfinaya ay la kordhiyo waxqabadka enzyme ee dhiigga. Marka la eego dhaqdhaqaaqa ee eulayska ogaado cudurada beerka (hepatitis, tobnad).

alanine aminotransferase kordhay galleeyda beerka, iyo sidoo kale hepatitis parenchymal. fiirsashada yar yahay ee enzyme waxaa ka diiwaan gashan hepatitis chronic iyo Dystrophy. Waa in la sheegay in la kordhiyo hawlaha alanine ee serum bilaabmaa 3-8 maalmood ka hor bilawga ah calaamadaha ugu weyn ee caafimaad ee cudurka iyo gaadho ugu badnaan in maalmaha hore ee horumarinta geedi socodka bahal ah.

Sayidka, alanine aminotransferase sii kordhay, cirrhosis of beerka, cagaarshow, kansarka beerka, Wadnaxanuun myocardial, failure xaq u wadnaha, hypoxia, shoog, myositis, myocarditis, tobnad, pancreatin, Khamriga chronic.