"Valsartan": tilmaamaha loo isticmaalo. Daawo "Valsartan" - analogues iyo dib u eegis

Daawada waxaa loo yaqaan "Valsartan" diiwaanka sharaxayaa sida hab isku daro, waxaa ka mid ahaa in kooxaha pharmacological durugsan nooca vasodilators. Isticmaalka daroogada this waxay leedahay saamayn hypertensive fahmayaan on bukaanka. Sidoo kale, daroogada this waxay leedahay saamayn nidaaam ee doorashada ee AT ₁ receptors in masuul ka ah hirgelinta habka of angiotensin II yihiin. Intaa waxaa dheer, saameynta durayo oo caan ku yeelan karaan on jidhka bini'aadamka waa qalab isu geeyey, sida "Valsartan". Analogs ee diyaarinta this - kaabsal "Diovan" "Exforge" "Tantordio" iyo "Valsakor" - leeyihiin guryaha la mid ah.

Features ficilka pharmacological

Sida muuqaalada ficilka pharmacological wakiilada antihypertensive, waa, yavlyas antagonist gaar ah ee loo yaqaan angiotensin II receptor, si wax ku ool ah ka xanibeen receptors AT ₁ iyo kordhisaa-fiirsashada plasma of angiotensin II ah. At daawooyinka la mid ah "Valsartan" (tilmaamaha loo isticmaalo sharxayaa ay ka kooban) ma la xakameeyo enzyme angiotensin-celiyaa. Sidoo kale, waxa aanu haysan waxqabad kasta oo agonist marka la eego AT ₁ -receptors. Waxyaabaha kale, asalka "Valsartan" ma xannibi channels ra'iyi iyo receptors hoormoonada kale ee lagama maarmaanka u ah xeerka caadiga ah ee nidaamka wadnaha. Intaa waxaa dheer, daroogada uu leeyahay saameyn ah kuma laha glucose tireoglobulinpa heerka, uric acid, kolestaroolkaaga guud iyo plasma ah.

Pharmacokinetics

Haddii aan ka hadlo oo ku saabsan pharmacokinetics oo ka mid ah wakiilada anti-hypertensive, xal daaweyn for "Valsartan", ka dibna, sida caadiga ah, waxaa aad si degdeg ah nuugo ka soo mareenka caloosha iyo mindhicirka ka dib markii maamulka afka, inkastoo heerka uu nuugista ku xiran tahay kala duwan shaqsi.

In this saamayn antihypertensive badanaa bilaabataa in ay dhacaan ka dib markii boqol - mid ka mid boqol iyo labaatan daqiiqo ka dib kacmaha hal daroogada, iyo saamayn-ku-daweynta ugu badnaan waxaa lagu gaarayaa celcelis ahaan afar - lix saacadood. The buuxda bioavailability of this daroogada waa ka badan 22%. Taa baddalkeeda, ku qabanaya borotiinka dhiigga (badanaa albumin) waa 94-98%. ansixin The plasma daroogada "Valsartan", kaas oo qaab-dhismeedka uu saamayn toosa ku dul, waa ilaa 2 L / h. Waxaa la soo bandhigay wakiilka antihypertensive inta badan in saxarada (oo ku saabsan 70%) iyo, ilaa xad aad uga hooseeya kaadida. sidoo kale soo saaraha ku nuuxnuuxsaday, in ay dhacdo xanibaadii laga shido bile ama cirrhosis biliary, this daroogada kordhay midowga afrika in celcelis ahaan qeybtii. In sarrifka isticmaalka daroogada wixii isbeddel ah ee guryaha pharmacokinetic iyo xuduudaheedu arkay.

Description of daroogada

Soo saaray daroogada antihypertensive "Valsartan" (tilmaamaha loo isticmaalo kaas oo loo baahan yahay waxaa ka mid ah in pack kasta) oo ah qaab kiniin, film-dahaarka leh, iyo qaab of budo cad. walax Tani waa ficil beelaya in biyaha caadiga ah oo si sahlan loo milma ee methanol iyo ethanol. Miisaanka uu leeyahay kelli ah dejinta ku saabsan 430-435 waa. Sida ka kooban of this-vasodilating dhexdhexaad ah, ka dibna sida waxyaalaha ugu muhiimsan ee hawlgalka waxa ku jira angiotensin II nooca receptor ah oo lagu durayo a thiazide.

Field isticmaalka dawooyinka

Qaado kiniinka "Valsartan" tilmaamaha loo isticmaalo waxaa intooda badan lagu taliyay in ay qayb ka mid ah wax-u therapy isku dhafan oo loogu talagalay dadka ay dhibaatadu ka chronic ee wadnaha ama hypertension.

Intaas waxaa sii dheer, taas wakiilka antihypertensive Illustrated isticmaalaa si kor loogu qaado badbaadada dadka la Wadnaxanuun myocardial ba'an (oo ay ku jirto cillad systolic ventricular adag ama ventricular bidix failure). Bukaanka qaba cudurka wadnaha qaata daawooyinka dhaqanka, diuretics ayaa sidoo kale marar badan maamulo daawo ah "Valsartan". Analogues qalab this sidoo kale waxaa loo isticmaali karaa in dhammaan kiisaska kor ku xusan.

qiyaasta

Qaado daawada antihypertensive, dhakhaatiirta sida caadiga ah ku talinaynaa hal ama laba jeer maalintii siddeetan ama afartan milligram, siday u kala horreeyaan. Maqnaanshaha saamayn la doonayo daweynta, qiyaasta maalinlaha ah waa la kordhin karaa. Si kastaba ha ahaatee, tani waa in si tartiib tartiib ah ku sameeyey oo kaliya uu dhakhtarku soo qoro. Qiyaasta ugu badan ee daroogada isla waa saddex boqol iyo labaatan milligram.

Liiska sababo isticmaalka

Isticmaal khubaro qalab-vasodilator si adag ugu talinaynaa in haddii uu jiro qof ka mid ah diidmo shakhsi in mid ka mid ah qaybaha. Marka lagu rakibay cadaanyo analogously waa in ay iska ilaaliyaan qaadashada kiniiniga "Valsartan". daroogada asalka ah waa in sidoo kale aan loo qaadan by bukaanka kuwaas oo aan gaadhin da'da siddeed iyo toban. Arintaan waxaa sabab u ah xaqiiqada ah in ammaanka isticmaalka daroogada antihypertensive in kiisaska noocaas ah aan si buuxda u fahamsan yahay.

Isticmaal inta aad uurka leedahay

Qoray daawada dumarka "Valsartan" kaasoo dhasho, gabi ahaan uu u. Kuwani cilmiga caafimaadka abaabulay muujiyaan khatarta ah si caddaalad sare ee dhibaatooyinka ee wakiilada antihypertensive on uurjiifka. Si kastaba ha ahaatee, haddii ay dhacdo cudurka nafta halis daran, taas oo waa wax aan macquul aheyn in la isticmaalo kale, daawooyinka ammaan, ama ay waxtar yar yihiin, codsiga ah ee vasodilator daroogada. Dhanka kale waa in la yiri ku saabsan lagu ogolaan ee isticmaalka qalab halka quudinta ilmaha dhasha la caanaha naaska.

kooxda reactions macquulka ah

Magacaabista sida daroogada ah antihypertensive, sida "Valsartan" keeni kartaa muuqaalka kore ee ah madax halkii daran, dawakhaad, qufac iyo daciifnimo. Intaa waxaa dheer, waxaa inta badan waa lallabo, shuban, hyperkalemia, syncope, iyo hurdo la'aan. Calool xanuun, vertigo, neutropenia, Torombositobiiniya, arthralgia, dhabar xanuun, myalgia, daal, iyo barar ayaa ku dhici kara iyada oo sababtu tahay maamulka daroogada la mid ah "Valsartan". Reviews bukaannada ayaa horay waxa uu u adeegsaday, sidoo kale waxay muujinayaan halista pharyngitis, rhinitt, hogaga, noocyo kala duwan oo cudurada viral iyo cudurada saameeya waaxda neefsashada sare. Intaa waxaa dheer, dad badan ayaa ka hyperbilirubinemia arkay, hoos u hiimotokiriit, hypercreatininemia, korodhsan content HOL dhiig nitrogen iyo hoos u dhac in unugga. Intaa waxaa dheer, waa in aad had iyo jeer la xasuusto in soo dhaweynta isku mar ah hab-vasodilator "Valsartan" iyo daawooyinka ka tirsan ee diuretics potassium-uubatooyin keeni kartaa horumarinta hyperkalemia. In the case of badinta daroogada dhici kara xaaladaha sida bradycardia, hypotension ama tachycardia.

Digtoonidiinna Duulana aasaasiga ah

Gebogebadii, waa in la sheegay in ay lagama maarmaan tahay si taxadir leh xad-dhaaf ah oo keliya ka yar kormeer caafimaad adag magacaabi soo dhaweynta ah wakiilka antihypertensive in bukaanka qaba deficiency sodium, xadgudub ba'an ee kelyaha, stenosis laba geesoodka ah ee halbowlaha waxa loogu yeero kelyaha ama hoos u dhac wayn ku wareegaya mugga dhiigga. Tan waxa u sabab ugu horrayn si ay bukaanada halista sare leh hypotension halbowlaha. Intaa waxaa dheer, waa in aad lacag bixisid si aad dadka ka cabanaya cirrhosis biliary ama xanuunada daran beerka fiiro gaar ah. Bukaanka qaba stenosis ah halbowlaha kelyaha u baahan tahay la socodka joogtada ah ee ku uruuray of nitrogen HOL iyo kariyaatiniin serum. Sidoo kale, fiiro gaar ah laftiisa ay u baahan yihiin bukaanka qaba xanibaadii mareenka biliary, qaata diuretics potassium-uubatooyin xunxun, kalisodergaszczye gaar ah supplements potassium ama daroogada. Ugu dambeyntii, taxadar xad-dhaaf ah waa in la isticmaalaa daroogada antihypertensive dadka "Valsartan" kuwaas oo shaqada la xiriira wadidda baabuurta kasta, iyo kuwa xirfad toos ah la xaajoon uruuray sare ee dareenka.