Qarnigii ugu danbeeyay ee daroogada statin: faa'iidooyinka, qiimaha, dib u eegista

daroogada statin Class ayaa ku dhexsameeysmo jirka iyada oo loo adeegsanayo si loo yareeyo xaddiga cholesterol serum iyo in la yareeyo halista wadnaha. Muddo dheer cilmi iyo dhakhaatiirta ka shaqeeyaan oo kaliya daroogada, "Lovastatin," "Pravastatin" "dawo", "Fluvastatin." Ayaa markaas ku dhexsameeysmo "Atorvastatin" iyo "Rosuvastatin" - waa qarni ugu dambeeyay ee statins, ama halkii, dawooyinka ugu badan ee wax ku ool ah in this category. Waxa kale oo hadda socda si ay u horumariyaan cusub, in waa ka sii ammaan ah oo wax ku ool ah statins, ka mid ah taas oo ay ugu caansan iska leh "pitavastatin."

sifooyinka General pharmacological of statins

All statins dhicin category ee daawo saamaynaysa-shiid la egyahay ee jirka aadanaha. Daawooyinka jireedka daweynta System Qoondaynta Kiimikada ay qoondeeyey S10AA code oo la xidhiidhaan inhibitors ee reductase HMG-CoA. Anada Activity of enzyme this, waxay carqaladeeyo ereygu wuxuu ahaa ee kolestaroolka, serum si weyn u yareeyo ay qadar. statins tallaabo Tani waxay u ogolaaneysaa in ay gaadho uruureen taliyay subaga low-cufnaanta ee dhiigga.

saamaynta waxay u suurto gal ah in si weyn loo yareeyo heerka horumarka of huurada atherosclerotic. Sidoo kale daawooyinka looga hortago in ay dhacdo. Xitaa haddii la heli karo in saamaynta qiimaha badan ee statins: waxay xasilin endothelium ee huurada atherosclerotic, in arrintan la xiriira, si weyn u yareeyo suurtagalnimada of thrombosis coronary, ku simaha by hab ka duwan therapy antiplatelet. Waxaa intaa dheer, isticmaalka wadajirka ah ee lacagaha, kuwaas oo ogolaanaya xitaa dheeraad ah si loo yareeyo suurtagalnimada of wadno. Maxaa yeelay, statins waxa loo xiraa on qiimaha ay tahay si buuxda cudur daar.

Gaar ahaan statins soocidda

Waxaa jira dhowr waji horyaalka galay fasalada daroogada. Waxay waxaa laga arki karaa marka la eego sifooyinka Avv. Sidoo kale, tan iyo daaweynta statins kala duwan waxay u baahan tahay qoondaynta qaabab kala duwan waa macquul inay soo bandhigto soocidda ah oo ku salaysan qiyaasta lagu taliyey. Qoondaynta qarniyo u egtahay sidan oo kale:

• Waxaan jiilka "dawo", "Pravastatin", "Lovastatin".
• Qarni II, "Fluvastatin."
• III qarnigan "cerivastatin," "Atorvastatin".
• Generation IV "pitavastatin," "Rosuvastatin."

All statins kala qaybsan yihiin macmal ah ka alaabta ceeriin, iyo dabiiciga dhexsameeysmo jirka. Arintaan waxaa ka mid ah "Lovastatin," "Pravastatin" iyo "dawo". daroogada dardaro waa inteeda kale:. "Fluvastatin," "Atorvastatin", "Rosuvastatin" iyo "pitavastatin"

Qoondaynta oo ah statins qaabab ku xiran codsiga

Dhammaan noocyada daroogada, oo ay ku jiraan jiilka ugu dambeeyay ee statins, miyir ku qaybsan dose hooseeyo (8 mg), srednedoznye (10-40 mg) ee sare (40-80 mg). Gaar ahaan:

• daroogada sare-bararka ( "atorvastatin", "Lovastatin" "Fluvastatin");
• daroogada srednedoznye ( "dawo", "pravastatin", "Rosuvastatin");
• daroogada dose hooseeya ( "pitavastatin").

kala soocidda Tani waxay ka tarjumaysaa suurtagalnimada of daawo oo kala duwan oo ku daweyn. Gaar ahaan,-daawooyin sare leeyihiin saamayn xaddiyo sare, halka si fiican loo dulqaatay. daroogada Srednedoznye, laakiin "rosuvastatin" ka yar si fiican loo dulqaatay at qiyaasood sare, laakiin saamayn wanaagsan.

statin Srednedozny "Rosuvastatin" loo qaadan karaa qiyaasta sare (80 mg), haddii loo baahdo, in kastoo sababta oo ah hoos u dhac ku filan dhamaystiran oo kolestaroolkaaga guud iyo jajabka low-cufnaanta in waxaa inta badan looma baahna. "Pitavastatin" oo ma u baahan tahay Ahaado oo tiro yar, sababta oo ah waxa khatarta dhibaato marar badan ka hooseeya in dhigooda fasalka.

Taariikhda horumarka iyo sal-dhigida ee statins

History of statins waa muranka. Markii hore, horumarinta waxaa si weyn caqabad ku aqoon la'aanta shiid kolestarool ah iyo suurtagalnimada of horumarinta atherosclerosis, taas oo ku xidhan heerka subaga dhiiga. Waxaa intaa dheer, gopoholesterinemicheskie mar ku dhexsameeysmo jirka ka dhigan tahay in la xakameeyo microflora dhaqamada of wasakhahaasi, loogu tala galay si aad u hesho penicillin saafi ah. Furitaanka of tallaabo cholesterol-cayimay tiro ka mid ah walxaha saaray by fangaska, iyo awood waxbarasho ee statins.

Waxa uu noqday statin ugu horeysay, compactin, oo aan soo bandhigay galay bukaan eegida sabab u ah fikrado badan oo is khilaafsan oo ku saabsan saamaynta ay. Waxaa la karantiilo dhaqanka cetrinium Penicillium. Markaas, ka dhaqanka ah Ruber Monascus ahaa monacolin go'doon K, xiranayo bishii February 1979. In 79aad June xiranayo iyo mevinolin, oo markii danbe bilaabay inuu qaado magaca "Lovastatin". daroogada waxaa loo isticmaalaa in rugta, ka dib waxaa la go'doonsan ama ku dhexsameeysmo by jiilka ugu dambeeyay ee statins.

Dad badan oo iska soo horjeeda statins views Ddareenka horumarinta, ka dib markii taas waxaa la go'aamiyay in ay sameeyaan oo baaxad weyn oo tijaabo. Si aad u taariikhda, ugu weyn oo ugu waxtarka ahaa daraasadda ee Scandinavian dawo Badbaadada Study. ay magaca gaabisay waxaa «4s». Waxaa si buuxda u diiday suurtogalnimada cudurada kansarka la xiriira maamulka daroogada, oo ay caddeeyaan in ay u isticmaalaan si weyn u kordhiyaa cimri iyo yaraynaysaa dhacdooyinka heley coronary ba'an.

Abstracts faa'iido u ah statins

Marka-fiirsashada hore ee kolestaroolka guud ee 7.4 mmol / l, therapy statin iyo si ay u gaaraan heer ah 5.4 mmol / L si weyn u yaraynaysaa halista ah ee dhacdooyinka wadnaha iyo dhimasho by 40% in ka badan 5 sano ee soo socota. Tiro ka mid ah waxbarashada kale ayaa muujiyay in hoos heerka guud ee kolestaroolka kaliya 1 mmol / L by shanaad yaraynaysaa suurtagalnimada of thrombosis wadnaha iyo halkan ka wadno ama stroke.

Tixgelinaysa statins, faa'iidada iyo khasaaraha ee ku Hadli badan oo aqoonyahanno iyo bukaanka, waxaan u garan karaa arrimahan soo socda: aad kuu qori karaa daawooyin sida ugu da'da 40 iyo wixii ka weyn, iyo yaraynta halista cudurka wadnaha - taatiko qumman ee nolosha dheereeya. Oo tan iyo qiimaha statins waa wax la heli karo, daawooyinka, kuwaas oo la xaqiijiyay ku ool ah, waxaa la qaadan karaa iyada oo aan waxba loo dhimayn maaliyadooda u gaarka ah. Dabcan, jiilka ugu dambeeyay ee statins badan ka qaalisan yihiin, inkastoo ay "Rosuvastatin" isku Mabda ', waa qaali ee bukaan socodka. Oo waa qaab diyaarinta ugu jaban "Merten".

sifooyinka barbardhiga: Waxa Ayidaya iyo Diidaya

Qiimaynta statins, oo iyaga ka gees ah ku hadlo aad u fudud. Doodaha "for" waa feature ah ay tallaabo-daweynta, yareynta kolesteroolka dhiigga iyo jajab low-cufnaanta, ka hortagga halista ah ee dhacdooyinka ba'an iyo caawinaad in ay daaweynta. Si kastaba ha ahaatee, daawooyin sida statins, waxaa kale oo jira sababo. Waxaa jira waxyeellooyin, dhexdhexaadin doodaha ka dhanka ah codsiga.

Marka therapy la statins halista ah ee myopathy. Waxaa macquul ah inuu dhex dhexaadin by Iscelin of ereygu wuxuu ahaa ee kolestaroolka, taas oo loo baahan yahay muruqyada. Inta jeer ee saamaynta ay tani tahay mid aad u yar yahay, inkasta oo ay kor u coadministration kale wakiilada hypolipidemic. Sidoo kale waxaa jira halis ah cudurada kansarka beerka, inkastoo jaaniska cudurka noocan oo kale ah, sida lagu muujiyey by baaritaano dhawaan, aad u hooseeya. At isku xaqiijiyay iyo xaqiiqda ah in kansarka la xanaajiyeen by arrimo kale. Sidaa awgeed, in diyaarinta ah "statins" sababo waa mamnuucayo co-maamulka daawooyinkan la wakiilada kale kor u hoos u dhac in fiirsashada of unugyada baruurta.

Qiimaha qarnigan ugu dambeeyay ee statins

On jiilka ugu dambeeyay ee statins qiimaha kala duwan, inkastoo saamaynta ay ka qiimo bixinta. Su'aasha kale waxay tahay oo kaliya in natiijada ee ay falsayeen waxaa lagu gaari karaa iyadoo la isticmaalayo jaban analogues fasalka Quruumihii hore. Gaar ahaan, statin ugu badan Generation IV "Rosuvastatin" qiimaha qiyaastii waa sida soo socota:

• 600 rubles for loox oo 40 mg,
• 400-450 looxa 20 mg,
• 300-350 10 mg,
• 200 rubles 5 mg.

xirmo ka kooban yahay 30 kiniin, oo ku filan muddo hal bil ah oo daaweyn ah, halka daaweynta qiimaha bil kasta "pitavastatin" waa qiyaastii sida soo socota:

• 1 kiniin mg kharash ah oo ku saabsan 700-750 rubles,
• Tablet 2 mg - oo ku saabsan 1000 rubles,
• kiniin 4 mg - 1500 rubles.

doorasho u dhexeeya "Pitavastinom" iyo "rosuvastatin" wuxuu ku salaysan yahay afar qodob: factor qiimaha, heerka of yareynta lipoprotein low-cufnaanta,-cufnaanta sare buuxnaanta kordhay lipoprotein, ammaanka. xawaaraha hoos kolestaroolka iyo kordhinta HDL, iyo sidoo kale qiimaha ugu fiican u muuqataa "Rosuvastatin", halka aragti dheeraad ah oo aamin ah waa "pitavastatin."

Socon laba jeer sida qaali ah marka la barbardhigo "rosuvastatin". Si kastaba ha ahaatee, waxaa suuro gal ah ee la isticmaalayo kale, statins jaban. The hore "dawo" dhaqaale ahaan ugu faa'iidada. Haddaba isagu wuxuu iska bedelay "Atorvastatin", kaas oo si joogto ah u bedelay "rosuvastatin" (miraheeda daruuri dhici doonaa). Oo haddii statins qiimaha jiilka ugu dambeeyay waa awoodi bukaanka, waxaa lagama maarmaan ah in la tixgeliyo suurtagalnimada ee daaweynta "atorvastatin" ama "dawo". By habka, waxbarashada ugu sameeyay leh "atorvastatin".

Dood ay guushu ku statins waayeelka

Hadda ka hor, shaqaalaha rugaha caafimaadku waa diidan in ay qori statins bukaanka ka weyn yahay 75 sano. Sababta oo ah arrimaha soo socda:

• soo dhaweynta, dhowr fasallo kale ee daroogada;
• cagajiidka labada dhinac ku daray fasalka kale oo daawooyinka,
• la'aan ama daaweyn komplaentnost hooseeyo;
• diidan ee bukaanada inay soo iibsadaan statins oo loo isticmaalo, maxaa yeelay la'aanta ah ee fahamkooda saamaynta ay.

Tiro ka mid ah waxbarashada ay fuliyeen la "dawo" "Pravastatin" iyo "atorvastatin" muujisay hoos u dhac weyn ee dhimashada ah ee bukaanka ka weyn yahay 75 sano. Waxaa intaa dheer, hoos u dhac ah ee dhimashada ahaa xataa ka badan in bukaannada ku jira kooxaha da'da 55-65 iyo 65-75 sano. Maxaa yeelay, daawooyinka of fasalka this (statins) comments ka khubarada si cad u Xaqiijiyay xaqiiqo ah.

Daawooyinka waxaa loo qaadan karaa waqti dambe ee nolosha loo eegin in ay jiraan kuwo xanuunada wadnaha hore ba'an. Oo bukaanka runtii waa arimo muhiim ah si loo yareeyo khatarta uu dhintay ka Wadnaxanuun infarction ama stroke, waxaad u baahan tahay in la fahmo in haddii daroogada ay tahay wax ku ool ah oo nabad ah, waa xaqiiqo ah oo qiimihiisu qaadashada. Gaar ahaan daaweynta in la statins uu noqday more la heli karo, oo sii wadi doona sida.

Maqaallo dib u eegista farcanka ugu dambeeyay ee statins

comments Bukaan-socodka qiimaynta tayada a statins generic gaar ah ma aha waxay muujinaysaa, maxaa yeelay, iyagu ma ay dareemeen isbedel weyn ka qaadato daawooyinka. Hagaajinta profile la egyahay dhiig kama muuqan gobolka ee caafimaadka iyo ma laha calaamadaha dibadda. Waxay aqoonsan profile la egyahay oo kaliya. Sababta oo ah marka statin qiimaynta caqli hanuuniyey khubaro u eegista. Oo ku saabsan diyaarinta, taas oo qayb firfircoon waa pitavastatin, khubaro maxalli ah oo aan ka jawaabi karaan.

In nidaamka bukaan eegida ee CIS "pitavastatin" sababta oo ah qiimaha sare iyo sababta oo ah joogitaanka "rosuvastatin" iyo xabbo ay ma khuseeyo. In diyaarinta "rosuvastatin", kuwaas oo kor ku xusan, talaabada deg deg ah: profile la egyahay caadi 1-2 bilood. The "atorvastatin" waa wakhti iyo wakhtiyo kala bar ka badan. Sidoo kale generic "rosuvastatin" ammaan, tan iyo markii labada noocyada yihiin metabolized by cytochrome ah. Waqtigan xaadirka ah, macluumaadkan waxa laga soo qaatay ee comments khubaro ah, waxaa door muhiim ah in doorashada ee statin xaaladaha caafimaad oo gaar ah.

The gunaanad guud farcankii dambeeyay ee statins

Daroogooyinka "pitavastatin" iyo "Rosuvastatin" ayaa ah kuwa ugu ka mid ah wakiilo ka socda fasalka statin ah, kaas oo jidhka badan oo caddaynaya ururiyey sare. saamaynta ay guud ahaan la mid ah kuwa ka mid ah "atorvastatin" waa, laakiin waxaa jira kala duwanaan. "Pitavastatin" iyo "Rosuvastatin" u ogolaan in ay gaaraan heerka kolestaroolka bartilmaameed, iyo lipoprotein cufnaanta yar qiyaasta a hoose ka badan "atorvastatin".

Waxa intaa dheer in Fadilmo ee kor ku xusan statins jiilka ugu dambeeyey muhiim ah oo waa arrin kale. Magac ahaan, in daaweyn jiray "pitavastatin" iyo "rosuvastatin" arkay caadi ah soonkii subaga dhiiga iyo homocysteinemia reebay. Tani waa muhiim sida kiiska cudurka wadnaha ba'an, iyo in bukaanka qaba cudurka wadnaha chronic, huriyay atherosclerosis wadnaha. Security isticmaalka statins ka badan kardioform acetylsalicylic acid. Si kastaba ha ahaatee, joogitaanka sababo mamnuucaya isticmaalka dadka bukaanka qaarkood (eeg. Sababo General).

tusaalooyin dejinteedu

Daawooyinka ay ku jirto "Rosuvastatin" heli karo magacyada ganacsiga ee soo socda: "AKORT", "Rozistark", "Rozukard", "Rozart", "Merten", "Rozulip", "Roxer", "Rustor", "Tevastor". Dhamaan daawooyinka waa kuwan generic "Crestor" oo noqday rosuvastatin ugu horeysay. Drug, kuna waari dhexdeeda walaxda firfircoon waa pitavastatin, ka diiwaan gashan sida «Livalo». xabbo ay «Pitavas» iyo «Pivasta». iyagu ma ay dhacaan CIS, inkasta oo ka diiwaan gashan Pharmacopoeia ah.

oo kooban

Iyadoo la tixraacayo fasalka ka mid ah saamaynta iyo falanqaynta waxtarka ay u isticmaalaan daroogada, isticmaalka statins loo damaano qaado, waayo, xasilinta huurada atherosclerotic oo looga hortago in ay dhaawac. Waxaa sidoo kale loo isticmaalaa si loo yareeyo xoogga atherosclerosis, saamaynaya profile la egyahay ee serum dhiigga. Sidaas darteed, fasalka this daroogada waa runtii loo baahan yahay in wadnaha. Iyo tayada oo ka mid ah statins jiilka ugu dambeeyay hore u yihiin hab wax ku ool ah ee ka hortagga thrombosis coronary dilaa.