Inhibitors Cholinesterase: isticmaalka pharmacological

Waxaa la og yahay in habka dareemayaasha jirka ayaa synapses badan. Waxay lagama maarmaan u yihiin gudbinta falalkooda. Marxaladani waxay ku lug leedahay dhowr nooc oo dhexdhexaadiyayaal. iyaga ka mid ah, - .., acetylcholine, norepinephrine, reer Gebacna, serotonin, iwm dhexdhexaadiyayaal (laliska) waxaa loo baahan yahay kala iibsiga ee calaamadaha u dhexeeya neurons. Waxaa intaa dheer, sabab iyaga waxaa la kaxaystay excitation ama muruqyada Iscelin. In heley kala duwan oo ka mid ah shaqada nidaamka neurotransmitters dareemayaasha lagu xadgudbay waxaa laga yaabaa in. Tani waxay dhacdaa ay sabab u tahay geedi socodka Atrophic iyo side maskaxda. Xaaladahan, isticmaala daroogada loo baahan yahay jaha ama attenuating signal gudbinta. By koox la mid ah pharmacological waa inhibitors cholinesterase. Waxay waxaa loo isticmaalaa in laga daweeyay, neuritis, amyotrophic lateral sclerosis, cudurka Alzheimers, heley dhimirka.

Saamaynta of inhibitors cholinesterase

inhibitors Cholinesterase - daawo ah in si weyn loo isticmaalaa in neurolojiga iyo maskaxda. Waxay kala qaybsan yihiin kooxo dhowr ah, kuwaasoo mid walba uu yahay dabaqi karo kiis gaar ah. tallaabo ee daawooyinkan dhaqmaan by xanibeen cholinesterase. enzyme Tani waa laga heli karaa labada dad caafimaad qaba iyo kuwa qaba cudurada kala duwan. Waxaa lagama maarmaan ah in dumin neurotransmitter ah - acetylcholine. Sidaas darteed of gudbiye tallaabo ay Dullaysane in choline iyo acetic acid. In heley kala duwan ee atrophy kiliyaha maskaxda waxay dhacdaa si tartiib tartiib ah. Sidaas darteed, qaab-dhismeedka qaar ka mid ah si buuxda u dumi karaan, oo ay ku jiraan nidaamka cholinergic. Ka sokow atrophy maskaxda, waxay keenaysaa in geeddi-side ah, shalalka, faafa dabiiciga ah, viral. Sababo la burburinta nuclei maskax-ka waxaa jira la'aanta fahmayaan of neurotransmitter - acetylcholine. Ilaa iyo inta ay suurto gal ahayd yaraanta lahayn oo ah walaxda, waxaa lagama maarmaan ah inay wax ka qabtaan on enzyme in ay wada baabbi'iyaa. Ujeedada this, inhibitors cholinesterase ah waxaa loo isticmaalaa. Thanks iyaga, hawl neurotransmitter Daa'imaan laga yaabaa in dhowr sano.

inhibitors Cholinesterase: daroogooyinka kala soocidda

Waxaa jira dhawr nooc oo ah dawooyinka anticholinesterase. Waxaa loo kala saaraa sida ay saamaynta pharmacological on eulayska. Qaar ka mid ah iyaga ka mid ah waxaa ka xanibeen cholinesterase karin, dadka kale - ku meel gaar ah. Qoondee 3 kooxood medicaments. Ka mid ah iyaga,

1. blockers karo. Kuwani inhibitors cholinesterase dhaqmaan on seylaanyenta postsynaptic. Thanks iyaga, enzyme waxaa ku meel gaar ah kala gooyey. Kooxdan waxaa ka mid ah acridines iyo piperidine.
2. Psevdoneobratimye blockers cholinesterase. Waxa ay qaab hawleed waa in lala qayb onionovoy ee Britain eulayska. Intaa waxaa dheer, waxay awoodi karaan inay ku xidhaan in receptors acetylcholine yihiin. guryaha Kuwani waa koox ka mid ah carbamates.
3. inhibitors karin ee cholinesterase. Kooxdaan daroogada loo yaqaan hab organo-phosphates. Wakiilka medicament ah "Metrifonate".

Kooxdu waxay of acridines ka mid ah daroogada "xambaara dayuuradaha" iyo "Velnakrin". Wakiilada carbamates - daawooyinka "rivastigmine", "Epistatigmin".

Tilmaamayaasha isticmaalka inhibitors cholinesterase

inhibitors Cholinesterase waxaa loo isticmaalaa in lagu daaweeyo cudurrada muruqa ka soo jeedo dhexe, atrophy iyo xanuunada maskaxda side. Intaa waxaa dheer, daawooyinka qaarkood ayaa laga heli karaa foomka of dhibcood. Waxay waxaa loo isticmaalaa at cadaadis intraocular kacsantahay - gulukooma. Daroogooyinka in la xakameeyo cholinesterase karo, la tilmaamay lagu daaweyn jiray dementia, cudurka Pick iyo Alzheimers. Xulasho waa in la siiyo koox piperidine, tan iyo markii ay yihiin ee doorashada oo ay leeyihiin waxyeellooyin yar. Sanadihii la soo dhaafay, oo tilmaan u ah isticmaalka daroogada kordhay. Tan waxa u sabab daraasad dheeraad ah oo faahfaahsan oo ah guryaha ay. Waayo, cudurada, taas oo ah daroogada anticholinesterase qoray waxaa ka mid ah laga daweeyay gravis, atony xiidmaha, Dystrophy muruqa ah, amyotrophic lateral sclerosis, curyaannimo of adimada asal side. inhibitors karin waxaa loo isticmaalaa haddii qof sumoobo.

Sababo isticmaalka daroogada cholinesterase

Daawooyinka ee kooxdan in aan loo isticmaalin xanuunada convulsive, hyperkinesis of etiology kasta. Waxa ay sidoo kale ahaan uu u bukaanka qaba wadnaha daran, neefta, thyrotoxicosis. Waa aan loo baahnayn in la qaato anticholinesterases la boog gastric saameen, enteritis. Daawooyinka aan la ogaaday in ay dumarka uurka leh iyo kuwa nuujinaya.

inhibitors Cholinesterase: doorashada ee daroogada cudurka Alzheimers

cudurka Alzheimers - waa Atrophic habdhiska dhimirka, taas oo ay jirto xusuus la'aan, jirro shakhsiyadda iyo dementia. Seynisyahanno adduunka oo ay isku dayayaan si aad u hesho daawo loogu talogalay cudurka this. At darnaanta fudud iyo kuwa dhexdhexaadka ah ee cudurka waa daroogada ah ee doorashada "donepezil". Waxaa loola jeedaa in inhibitor a cholinesterase karo, waxay leedahay saamayn la xushay. daawada loo isticmaalo ujeeddo ah therapy pathogenetic. Isagu ma awoodo in lagu daaweeyo bukaanka si buuxda, laakiin gaabisaa horumarinta calaamadaha cudurka Alzheimers.