Imidazoliletanamid pentandiovoy acid: tallaabo pharmacological, codsiga, analogues

Haddii dhakhtarkaagu ayaa laga helay a "cudurka viral", waxay ka dhigan tahay in aad u baahan tahay in si fiican loogu daweeyo. group A caddaalad ah oo waaweyn muwaadiniinta walaalahooda ay aaminsan yihiin in antibiotics - daawaynta ugu fiican ee cudurrada oo dhan. Nasiib darro, waa fikrad khaldan in wax la yeelo wax badan ka badan meejeeda dhabta ah. Antibiyootikada way firfircoon yihiin oo kaliya cudurada bakteeriyada, laakiin ay yihiin bilaa awood fayrusyada.

Sidee shuqulladii daroogada?

Waxaa jira tiro badan oo ah daroogo la hawl antiviral. Mid ka mid ah walxaha ugu badan in ay leeyihiin hanti - waxa ay imidazoliletanamid pentandiovoy acid.

Waa firfircoon ka dhanka ah wareer ah noocyada hargabka A iyo B, adenovirus, parainfluenza iyo caawisaa jeermiska fayraska syncytial neefsashada.

Tani xarunta firfircoon leeyahay hab gaar ah garoomada. Waxa uu hakiyo geedi socodka taranka yada wajiga fayrusyada yaruna iyo sidoo kale retards socdaalka ee wakiilka cusub ee faafa ka unugyada deegaanka Bu'da cytoplasmic.

Sidoo kale pentandiovoy imidazoliletanamid acid waxaa si firfircoon uga qayb nidaamka difaaca jirka aadanaha, bixinta saamayn modulating ah. walax waxa ay kordhisaa content interferon dhiig heerka caadi ah nafsaaniga ah. waxa ay sidoo kale wuxuu kobciyaa nidaamka of α-, leukocytes γ-interferonproduktsii, taasoo keentay in xaalad u dhiganta hawlahaas.

Baarista oo ah walaxda firfircoon muujisay in imidazoliletanamid pentandiovoy acid kor u qarniga tallaabo limfosaytis cytotoxic. Waxaa intaa dheer, waxay kordhisaa tirada NK-T-wakiilada in ay leeyihiin awood u unsurpassed si loo burburiyo unugyada loo bedelay la fayrusyada, iyo sidoo kale fal toos ah on wareer ah.

Faa'iidada waa joogitaanka daroogada lahaa guryaha anti-bararka. Waxay waxaa la siiyaa by xakamaynayaan soo saarka ee profile cytokines, iyo sidoo kale hoos u dhacay firfircoonida ee myeloperoxidase eulayska.

saamaynta ku daweynta

Imidazoliletanamid pentandiovoy acid, dib u eegista ah oo fiican, soo socda ayaa muujinaya saamaynta ku daweynta ee daaweynta ee SARS iyo hargabka;

• Waxay yaraynaysaa muddada nidaamka xummada leh.
• Yaraynaysaa calaamadaha sarkhaan (wareer, xanuun, tabar).
• Yaraynaysaa daliilka catarrhal.
• Yaraynaysaa in dhibaatooyin xanuun this.
• Yaraynaysaa muddada jirrada.

Daawooyinka la pentandiovoy imidazoliletanamidom acid

farmashiyaha ayaa laga heli karaa daawooyinka soo socda oo ka kooban imidazoliletanamid acid pentandiovoy:

• budo "Vitaglutam".
• "Ingavirin" ee foomka of kaabsulka.
• kiniinka "Dicarbamine".

sababo

Sida wax imidazoliletanamid daroogada pentandiovoy acid - daroogada taas waa in lagu maamulo uu dhakhtarka xaadirka ah. wax soo saarka dawooyinka waxa uu leeyahay sababo, oo ay ku jiraan:

• Xilliga uurka iyo nuujinta.
• Carruurta da'doodu tahay ilaa 18 sano.
• Diidmo ah qaybaha daroogada.

Dhibaatooyinka ay keento ka daawo ay ku jirto walaxda tilmaamay firfircoon lagu sheegi karaa in qaab-celinta xasaasiyadeed.

saamayn Tani waxaa la siiyaa in qofka uu leeyahay dareen u gaar ah si ay u imidazoliletanamidu pentandiovoy walxaha acid ama kaabayaal ah, kuwaas oo qayb ka mid ah daroogada.

ammaanka

Dadka qaarkood waxay isku dayaan in ay ka fogaadaan isticmaalka daroogada this, iyagoo rumaysan in imidazoliletanamid pentandiovoy acid - waa antibiotic ah. view Tani waa qaldo, tan iyo this walax firfircoon muujinayaa hawl antiviral kaliya. tayada yeedhay diidaa isaga oo dhan dhibaatooyinka soo raaca in ay yihiin profile antimicrobial soo jireenka ah daroogada. Daawada ma laha tallaabo immunotoxic, kansar, mutagenic ama xasaasiyad aan diiqayaa marinka dheef shiidka aan la yareeyo shaqo taranka ma laha embryotoxic ama saamayn teratogenic.

Calaameeyay hawl halkii sare ee daawooyinka ka kooban yihiin imidazoliletanamid pentandiovoy analogs acid taas waxaa laga qaadaa afka. Waxaa si degdeg ah nuugo in mareenka caloosha iyo mindhicirka oo ay si siman u qaybiyey xubnaha iyo unugyada. Horeba ka dib markii nus saac ka dib markii uu qofku cuno ee qayb ka daawo gaadho fiirsashada ugu badan ee dhiigga iyo qabtay 37 saacadood. Muddada aad daawada ahaa 5 maalmood. Maamulka kasta oo daroogada boodi ah ay ka kooban tahay ee dhiiga, kaas oo si tartiib ah hoos inta lagu jiro maalinta. daroogada ee jidhka bini'aadamka looma metabolized saarka beddelin by kelyaha iyo mindhicirrada.

soo dhaweynta feature

Waxaa muhiim ah si ay u dhawraan mudada qiyaasta of daroogada ah. Imidazoliletanamid pentandiovoy analogs acid waxaa lagu gartaa qiyaastii talo isku mid ah loo isticmaalo, waa in afka laga wada baabbi'iyey hal mar maalintii qadarkuu of 90 mg muddo ka badan 5-7 maalmood, iyadoo aan loo eegin hadhuudhka ah.

peculiarity ee daaweynta this wakiilka ah dawooyinka waa in hufnaan ugu weyn waxaa lagu gaarayaa marka la siiyo ka dib markii laga arko calaamadaha ugu horreeya ee cudurka labada maalmood ee ugu horreeya gudahooda.

"Vitaglutam" - isha kooxda wakiilada fayruska

Taariikhda daroogada dib u 70s ee qarnigii la soo dhaafay. Waxaa la horumariyo by pulmonologist dhakhtarka caanka Ruush Alexander Chuchalin. medicament wuxuu ka kooban yahay sida firfircoon imidazoliletanamid qayb pentandiovoy acid ugu weyn. "Vitaglutam" la soo bandhigay magaca ganacsiga "Dicarbamine" ilaa 2008. Qasdigiisa ahaa in, in ay kicin nidaamka hematopoiesis in bukaanka soo maray daaweyn therapy kansarka.

Sannadkii 2009, dadka la soo wajahay cudurka daran virus - hargabka doofaarka, ama A / H1N1. Wakhtigan, "horumarinta Vitaglutama 'ayaa ahayd mid aad u khusayso. Aleksandr Chuchalin, kuwaas oo ahayd waqti in dhakhtar sare ee Ruushka, ay go'aansadeen in ay tijaabiso abuurkiisa fayruska hargabka doofaarka oo uu gaarey natiijooyin guul leh. Waxa uu sheegay in wax soo saarka qoyska, kaas oo ku salaysan imidazoliletanamid pentandiovoy acid, "Vitaglutam" muujinaysaa waxtarka aad u weyn ka dhanka ah cudurka amaanaa badan sheyga American dawooyinka "Tamiflu". Waxa uu si firfircoon daro hiddawadayaasha ah viral, iyo Halaagtay.

Life New "Vitaglutam" daroogada "Ingavirin"

Chuchalin jeediyay Gennady Onishchenko, dhakhtar sare nadaafada ee Ruushka, si ay u isticmaalaan oo uu been abuurtay sida qalab wax ku ool ah ee daaweynta ee hargabka doofaarka. Sidaas darteed of tijaabo ee daroogada ayaa lagu sameeyay, taas oo u xaqiijisay in ay ku oolnimada la eego cudurada kala duwan viral. Daawada waxaa la siiyey magac cusub "Ingavirin" oo waxaa ka diiwaan gashan diiwaanka ee kooxda oo ah daawooyinka fayruska iyo immunostimulatory.

Marka alaabta this waa shirkad dawooyinka "Valenta" tegey on sale, waxaa si rasmi ah waxaa lagula talinayaa in ay Wasaaradda Caafimaadka sida daaweynta ifilada doofaarku oo bilaabay inuu ku garaacday diiwaanka caan ka mid ah dadweynaha. Sidaas darteed, waxaan dhihi karaa oo ku saabsan isku midka ah "Dicarbamine" - imidazoliletanamid pentandiovoy acid - "Vitaglutam", in uu yahay, dhab ahaantii, hal iyo daawo la mid ah.

Waxaa xusid mudan xaqiiqada ah in "Ingavirin" tegey on sale ee 2008, oo aan tijaabo buuxda. Iyada oo gargaar ah Onishchenko 2009 degdegsiimada tijaabo on jiirka shaybaarka ayaa soo abaabulay. Sidoo kale haddii ay dhacdo this, ka soo qayb galay 100 bukaan ka qaybgalay. Iyada oo ku saleysan natiijooyinka kooxda daraasadda keentay in Chuchalin ku soo gabagabeeyey in "Ingavirin" 48 saac ee ugu horeysay tan iyo bilowgii cudurka gudahood tusay wareer ah cudurada oolnimada sare. Its tallaabo ka muuqataa hoos muddada xummada leh, hoos u sumoobo in xayawaanka shaybaarka iyo bukaanka iyo in la yareeyo daliilka catarrhal.

Sidaa darteed, ma jirto sabab in aad ka fikirto imidazoliletanamid pentandiovoy acid waa masaasad - ay ku oolnimada waxaa caafimaad ahaan la xaqiijiyay.

"Dicarbamine" maanta

Currently, dhammaan saddexda daroogada on pentandiovoy acid imidazoliletanamida sal ganacsi ka jirin oo ay u taagan sida dhigooda midba midka kale.

"Dicarbamine" talinayo in la isticmaalo by bukaanka qaba joogitaanka burooyinka halista ah. Waxa intaa dheer in qayb weyn ee firfircoon, waxa ku jira sonkor caano ah, Rusheyn kartaa, istaarijka baradho, milmahayn magnesium, xal Kolloidol ee Silicon dioxide iyo stearic acid.

"Dicarbamine" ayaa saamaynta ku daweynta soo socda:

• Acceleration of kaladuwan nuutrofilkaagu iyo koriinkedu functional.
• Gematoprotektsiya la chemotherapy myelosuppressive.
• Yaraynta inta jeer ee dhacdo iyo degree of neutropenia sun ah, leukopenia yareysey.

diyaarinta waxa lagula talinayaa in aad dalbato u dhexeeya kooxihii chemotherapy.

Its waxtarka hore u Muuqda 21-28 maalmood ee maamulka maalinlaha ah ee kiniiniyada ka dib.

Hal dose oo ah daawo - 100 mg (1 kiniin) - qaaday 5 maalmood ka hor bilowga chemotherapy iyo sii daaweynta oo dhan. "Dicarbamine" ayaa hantida si kor loogu qaado oo uu cimrigiinnu ku tallaabo daroogada cytotoxic anticancer, si loo yareeyo waxyeello sun ah cyclophosphamide iyo daroogada platina ku salaysan, iyo sidoo kale waxay keeni in geedi socodka caadiga ah ee hematopoiesis.