Antibiotic "Remedy": tilmaamaha loo isticmaalo, dhigooda dhabta ah

daaweynta ee hadda ah hababka faafa, waa wax aan macquul aheyn oo aan isticmaalka daroogada bakteeriyada. iska caabin ah ayaa mar walba sii kordheysa ee sheyga ka dhigaysa raadinta daawooyin cusub ama isticmaalka isku jir ah, antibiotics xaqiijiyay. Ma ay guushu ku adeegsiga qumman ee antimicrobials waxaa daliil u ballan reer caasiyoobay antibiotics ballaaran spectrum, halkii qiimaynta hore ee dareenka ee flora daroogada ee kooxdan. Drug "Remedy", haysashada pharmacokinetic weyn iyo faa'iidooyinka pharmacodynamic in tiro ka mid ah fluoroquinolones sii kordheysa loo isticmaalo daweynta cudurrada faafa ee etiologies kala duwan.

sifooyinka Clinico-pharmacological

medicament The "Remedy" ama "levofloxacin" (International noocan Name) waa antibiotic ka fluoroquinolones taxanaha ah, loogu tala galay wadooyinka enteral iyo parenteral maamulka.

By dabiicad ahaan "Remedy" (diiwaanka ku siinayaa macluumaad sax ah sida) waa monoftorhinolonom - isomer of ofloxacin, iyo marka la barbardhigo daawooyinka kale, uu leeyahay faa'iidooyin pharmacokinetic muhiim ah:

• bioavailability afka waa 100%, heerka uu xiriir la borotiinada plasma u sarraysaa sida 40%;
• ugu badnaan daroogada serum dhiig lagu arkay 1-2 saacadood ka dib markii maamulka afka waa dhigma in ka dib markii maamulka xididka;
• "Remedy" waxa lagu gartaa mugga kordhaysa oo ah qaybinta ee jirka, ay sabab u tahay wax lays degdegga ah tiftafyadiisa;
• Waxay leedahay nus-cimri dheer ee u shaqeeyo sababa keliya dhoos keli ah daawada maalin kasta.

Marka la eego in a fluoroquinolones saameyn ku daweyn la taaban karo sababa heerka deg deg ah ee u kaca ee fiirsashada dhiigga daroogada ku-daweyn ah, ku soo koobin pharmacokinetic sheegnay bixiyaan xaaladaha wanaagsan loogu talagalay reebay dhamaystiran oo sheyga.

Sida laga soo xigtay iyaga oo nooca tallaabo on koritaanka iyo taranka bakteeriyada, "Remedy" uu saameyn ku bactericidal, saamayn ma aha oo kaliya on foomamka firfircoon ee bakteeriyada pathogenic, laakiin sidoo kale in daaqsinka iyo firfircoonayn.

Dheef-daroogooyinka qaar ka mid ah waxay ku dhacdaa hepatocytes by deacetylation ama lagu qayilo. Si kastaba ha ahaatee, oo ku saabsan 5% ka mid ah daroogada saxarrada kelyaha sida metabolites, oo ka dhiman la sii daayay iyada oo loo marayo sifeynta glomerular iyo dheecaan embriyaha. Waa in la ogaadaa in ka dib markii maamulka afka qayb muhiim ah oo daroogada (70%) waxaa raaca jidhka ka 24 saacadood gudahood, laga bilaabo kaadida, iyo wax ku saabsan 80% qiyaasta la tirtiro 48 saacadood ka dib. Saamiga Digo of daroogada iyada oo mareenka caloosha iyo mindhicirka yar tahay oo waa kaliya oo ku saabsan 4%.

Marka la isticmaalayo daroogada ee qiyaasood oo ka badan 1000 mg maalintii (kiniinno laba jeer-maalin walba ah ee 500 mg) looma filayo of horumarinta saamayn wadareed.

hab of action

hab ay of tallaabo daroogada ku saleysan Iscelin of enzyme gaar ah u yeedhay gyrase DNA, taasoo ku lug leh geeddi-taranka ee wax hidde ah by tola gariiradda wanaagsan in DNA galool xun. Sidaas darteed of Iscelin of hababka enzyme xad ah ee taranka DNA, qeybinta unug, dhimashada unugyada dhacdaa.

"Remedy": tilmaamaha loo isticmaalo iyo tilmaamo

Si aad u taariikhda, ku tilmaamo weyn ee dejinaya geedi socodka waa etiology bakteeriyada faafa, sababa nooc nugul ee sheyga in antibiotic ee bukaanka ka weyn yahay 18 sano.

Diyaarinta "Remedy" hab fiican cadaato in daaweynta caabuqyada neef-bakteeriyada ka mid ah caabuqyada neef-mareenka sare iyo hoose sida boronkiitada ba'an, hogaga, cudurada bararka ee unugyada sambabada. Tan waxa u sabab, dhammaan ayuu ka sarreeyaa, lays daroogo fiican galay epithelium reer hawomareenno iyo sambabada halkaas oo xitaa ka dib markii maamulka ugu horeysay ee daroogada abuuraa fiirsashada wax ku ool ah.

dejinta ayaa isku si guul leh loo isticmaalaa in lagu daaweeyo cudurka kaadi mareenka (hurgumada kilyaha, cystitis, urethritis, iwm), cudurada Biliary mareenka, prostatitis, cudurada maqaarka, cudurada intraabdominal iyo sepsis.

Si loo daweeyo cudurada faafa ee marinnada hawadu ee "Remedy" waxa lagu qoray (ku xiran tahay darnaanta cudurka) 1-2 jeer maalintii la 500 mg, halkii kaniini, ama diyaarinta isku duro.

Waayo, daaweynta infekshinka kaadida waa qiyaas ku filan oo lagu diyaariyo 1, 250 mg maalintii hal mar, iyo xaaladaha daran, qiyaasta maalin kasta waxay noqon kartaa 500 mg ( "daawaynta 500"). Tilmaamaha loogu isticmaalo ayaa sheegay in qiyaas laba jeer-maalin walba ah ee 250 mg lagu beddeli karo hal 500 mg ah ku xiran tahay darnaanta cudurka.

Waayo, daawaynta cudurada faafa ee maqaarka iyo xabka "Remedy" waxaa loo xilsaaray in qiyaasta a of 250 mg laba jeer maalintii.

sababo

contraindication Absolute in la helo daroogada waa diidmo iyo dareen diidmo oo xasaasiyadeed ay goobjoog ka ahaayeen taariikh fluoroquinolones daawooyinka.

data kama dambaysta ah ee ku saabsan maamulka daroogada inta ay uurka leedahay, ma, sida waxbarashada gacanta ku buriyay teratogenic ama embryotoxic aan la sameeyay.

In view of this ballan "Remedy" haweenka uurka leh waa in laga fogaadaa, marka laga reebo xaalado khataraha ka iman kara maamul oo ah walaxda waa ka hooseeyaa faa'iidooyinka ka.

In the case of daroogada ee bukaanka ka cabanaya porfyri, waxay keeni kartaa xaalad xumeyd ee cudurka.

Iyada oo xal galiyey taxadar gaar ah waa in la dalbadaa in bukaanka qaba lesions ka hor of habka dhexe ee neerfayaasha (stroke, wadne, dhaawac maskaxda), ay sabab u tahay suurtagalnimada sare ee dalalka convulsive.

Waayo, bukaanka oo la habab adag oo ka shaqeeya shaqo ama wado baabuur ah, ma jiraan wax tilmaamo gaar ah, laakiin fekero suuragalnimada in waxyeellooyinka ee nidaamka dhexe ee habdhiska qaab hurdo, wareer, iyo kuwa kale. Taa aawadeed waa ka fogaadaan shaqada noocan ah.

waxyeellooyin

Mid ka mid ah dhibaatooyinka ugu weyn in la horumariyo in bukaanlayda qaadato fluoroquinolones, waa cudur ka mid ah burburka carjawda chondrocytes epiphyseal sabab iyo unug laftiisa. In view of this daroogada waa u dadka ka yar 18 sano iyo haweenka uurka leh. Waa in la ogaadaa in ee bukaanka in ka badan 18 sano jirka ah la tixraacayo isticmaalka muddada-dheer ee daroogada ayaa lagu arkay dhacdo of arthralgia ama cillad ee kala goysyada. Ka mid ah waxyeelo kale oo jira soo socda.

On qayb ka mid ah mareenka caloosha iyo mindhicirka - lallabo, matag, rabitaanka cuntada oo luma, muuqaalka kore ee dareenka raaxo ee gobolka gaastari, waxaad heli kartaa dhiig caloosha iyo mindhicirka iyo horumarka ee caloosha; kordhiyo transaminases ee plasma dhiigga.

On qayb ka mid ah nidaamka dhexe ee dareemayaasha - horumarinta calaamadaha encephalopathy, madax-xanuun, wareer, miyirka oo luma, hurdo xumo, iyo Isbedellada joogtada ah ee niyadda, muuqaalka kore ee paresthesias, dhalanteed iyo dhibaatooyinkooda.

On qayb ka mid ah habka difaaca jirka - horumarinta dareen diidmo oo xasaasiyadeed sida finan maqaarka, cuncun, iyo horumarinta kartaa photodermatitis bixiyo insolation sare.

Laga soo bilaabo nidaamka kaadi - horumarinta crystalluria.

Nidaamka dhacdo neefsashada badan tahay ee bronchospasm iyo nidaamka wareegga dhiigga - Hoos u fiiqan ee cadaadiska dhiigga, reaction horumarinta hypoglycemia by hemostasis gacanta (foomka of Torombositobiiniya, iwm).

Dhexgalka daroogooyinka kale

daroogada fluoroquinolone aan wada maamula la laabjeexa, maadaama ay tani si weyn u yaraynaysaa nuugista iyo bioavailability of antibiotics. Aan lagula talinayaa in codsiga wadajira "Remedy" diyaarinta bir ah, iyo sidoo kale daawooyinka wax-yeeleya waxqabadka functional of habka dhexe ee neerfayaasha. Intaa waxaa dheer, waxaa jira caddayn ah oo ku saabsan saamaynta probenecid iyo cimetidine on Digo ee daroogada (walxahan waxay awoodaan si loo yareeyo tirtirista antibiotic).

calaamad u dirayaan of isdhexgalka daroogada la levofloxacin ma. In view of-shiid hoose ee daroogada ah ee unugyada, cagaarshowga iyo la'aanta ah ee is dhexgalka ensaymes ee kooxda P450 cytochrome «Remedy" ma dooriyo waxqabad ee la soo dhaafay, laakiin inkastoo this, sida xubnaha kale ee fluoroquinolone ah, daroogada waa in aan la isku daro daawooyinka teofilinovogo taxane oo aan toos ahayn xinjirowga lidka ku ah, ay sabab u tahay kor u suurto gal ah in ay fiirsashada ee dhiigga.

Isticmaalka daroogada lagu jiro naas-nuujinta

Si aad u taariikhda jiro wax macluumaad ah oo ku saabsan awoodda ee daroogada si uu dhex gelin caanaha naaska hooyada. Haddii ay jirto waa lagama maarmaan ah therapy antibiotic inta lagu jiro naas-nuujinta, stop ee la soo dhaafay markii lagu taliyey (muddada ay ku xiran tahay darnaanta caabuqa iyo muddada la filayaa daaweynta antibiotic). Haddii ay lagama maarmaan si ay u ilaaliyaan nuujinta soo saaro shubto wareegsan ama joojiso nuujinta oo gebi ahaanba qaab caafimaad.

Xaaladaha xad-dhaaf ah, naas-nuujinta iyo antibiotics waxaa laga yaabaa in qiimeynta khatarta ah ee carruurta iyo hooyada.

foomka Release iyo qiyaasta

"Remedy" waxaa la soo saaray ee laba nooc: maamulka enteral iyo parenteral. Waayo, maamulka afka waxaa kiniin ka kooban 250 ama 500 mg ah ee daawada (siday u kala horreeyaan oo hoos magacyada ganacsiga ee "Remedy 250" iyo "500 Remedy" ka). Waayo, maamulka parenteral xal faleebo laga heli karaa.

Kiniiniga "Remedy" ayaa laga qaadayaa 1-2 jeer maalintii cuntada ka hor ama inta u dhaxaysa hababka ay ma aha dareere ah, majuujin biyo ku filan. Haddii ay dhacdo in baahida loo qabo in qiyaasta qaybiyaan nus ka mid ah daroogada, kiniinka jebin karaa qoraalka laba qaybood.

Waayo, maamulka parenteral, xal la isku duro waa la heli karaa uruureen firfircoon 500 mg / 100 ml oo xal ( "daawaynta 500"). In the case of duridda xididdaha, hordhaca ah ee daroogada ahaa ma ka dhaqso badan 1 saac.

guurka dheeraad ah si qaab kiniin ah waxaa lagula talinayaa in ka dib markii maamulka galiyey. duration filayaa ku xiran tahay darnaanta caabuqa iyo dareen ee sheyga pathogenic in antibiotic ah. Therapy (eegin qaab maamulka) waxaa lagu dhiirigelinayaa in ay sii wadaan muddo 3-4 maalmood ka dib caadi ah heerkulka jidhka. daaweyn gaar ah iyo joojinta hore ee daroogada laguma talinayo sababtoo ah khatarta sare ee reactions dhinac iyo horumarinta suurto gal ah in ay iska caabin ah microflora daroogada.

ganaaxyada

Ka hor inta therapy isticmaalaya "Remedy" diiwaanka waajib haysta baarka dareen dhaawac microbial in daroogada. Si kastaba ha ahaatee, tan iyo qaybaha kala duwan ee ficil, daaweynta, waxaa curin kara iyada oo aan qabashada shaybaarka, ku xiga go'aan daroogada ugu waxtarka badan.

Howl a daawo "Remedy", fiiro gaar ah in la bixiyo, in baadhitaanka loogu talagalay si ay u qiimeeyaan socodka dhiigga kelyaha, tan iyo bulk of daroogada waxaa raaca iyada oo u kelyaha. Marka xadgudubyada daroogada dose shaqo ee la soo dhaafay loo baahan yahay in wax laga beddelo si waafaqsan ansixin ku kariyaatiniin qoomiyadda.

qaab diyaarinta galiyey gebi ahaanba la mamnuucay isku qasan oo leh xal loogu talagalay irbado, kaas oo ay leeyihiin dareen-celin xumadoodu ah (sodium bicarbonate), iyo heparin. Ujeedada dilutions galiyey rasvor "Remedy" socon xal sodium chloride isotonic, isotonic glucose xal "Ringers".

Inta lagu guda jiro soo dhaweynta, "Remedy" waa in ay ka fogaadaan cabitaanka aalkolada, in ay wanaajisaa saamaynta sun ah levofloxacin on habdhiska dhexe iyo muujinta inta badan sameysa ee waxyeelo.

Haddii, si kastaba ha ahaatee, go'aansaday on iyaga u gaar ah si aad u dalbato ah "Remedy", tilmaamaha loo isticmaalo, analogues, waa in si taxadir leh loo baaro, maxaa yeelay, waa tirada buuxda oo macluumaad iyo ku tiirsanaanta aqoon ku filan oo ah diyaarinta looga fogaado doonaa qaladaad.

Kaydinta iyo sahayda farmashiyeyaasha

xaaladaha kaydinta Gaarka ah ee daroogada looma baahna. Its ammaanka la hubinayaa Heerkulka 25 degrees Celsius. Laga soo bilaabo farmasiyada "Remedy" (antibiotic) qoro.

Marka aad iibsanayso soo saarka waa lagama maarmaan in ay bixiyaan si ay ugu daacadnimada iyo ammaanka ee baakooyinka, taariikhda wax soo saarka iyo nolosha shelf dareenka. Waa in la joogo in sanduuq oo ah dawada "Remedy" diiwaanka qasab noqon. Kiniiniyada waa in ay Baakadaha oo tayo sare leh. Waxaad ka eegi kartaa dareenka taabashada waxaa ka mid ah (sida u muuqato mid la yaab leh). Tan waxa u sabab xaqiiqada ah in qaar badan oo ka inta badan suuqa dawooyinka been abuurka ah waxaa jira oo faalsada ah, kuwaas oo ugu wanaagsan ee aan awoodin in ay saamayn bakteeriyada ku filan marka afka laga qaato, iyo ugu xun - keenaan waxyeelo daran. Sidaa darteed, helitaanka daawada, ha noqon caajis si aad u weydiiso farmashiistaha ku saabsan joogitaanka shahaadada tayo leh, isagoo rumeyn Quraanka asalka ah ee daroogada, "Remedy" (kiniin). Tilmaamaha loogu isticmaalo (daawada iibsan) waa ku jira macluumaad ku saabsan asalka ah ee lacagta.

badinta

Xaaladdan oo kale ma jiraan wax iska badiyo daawo gaar ah. Symptomatology ka badan qiyaasta waa sababta ugu waynina ay saameyn ku leeyihiin dambaysta ah ee ay hawshu u functional of habka dhexe ee neerfayaasha. Xaaladdan oo kale, waxaa jira jahwareer maskaxda, la qabsi, dawakhaad, iyo astaamaha excitation ee habka dareemayaasha ee foomka of psychosis, suuxdin, iyo kuwa kale.

Daaweynta waxaa loogu talagalay Digo ee degdeg ah ee daroogada. Marka la eego bioavailability sare iyo qaybinta daroogada ee jidhka oo dhan, hababka naanin kelyaha sifeeya ah ma yeeshaan. Waxaa lagama maarmaan ah in la joojiyo socodka daroogada galay jidhka iyo si ay u fuliyaan daaweynta calaamadaha.

Sababta oo ah in xididada badan ee "Remedy" by sifeynta ee habka glomeruli kelyaha wax ku ool ah u detoxifying waa in la isticmaalo xal cusbo aqueous iyo faleebo of daroogada lagu durayo tallaabo noocan loop.

Reviews of diyaarinta

Asal arkay jawaabo wanaagsan on daroogada sababta oo ah oolnimada sare oo lagu daweeyo cudurada faafa ee etiology kala duwan. Sida ku xusan tilmaamaha "Remedy" loo isticmaalo ee dib u eegista daroogada hadhay bukaanka ma aha oo kaliya, laakiin sidoo kale dhakhtarro, kuwaas oo xusay in ay ku oolnimada sare, ilaa daaweynta cudurada nosocomial iyo nosocomial.

Dib u eegista xun iyo qanacsanaanta daroogada ayaa inta badan ka tagay bukaanka. Tani waxay sabab u tahay horumarinta dhibaatooyinkooda ama habka aan habooneyn ee Remedia. Hase yeeshee, waxbarashadu waxay bixisaa macluumaad dhamaystiran oo loogu talagalay diyaarinta. Dib-u-eegisyada xun waxay sababaan isticmaalka sheyga daawooyinka ee kiisaska marka aysan waxtar lahayn sababtoo ah isma-marin la'aanta ficilka ficil-celinta fayruska ee fayraska microbial. Waa in la ogaadaa in fikradaha muhimka ah ay inta badan ka tagaan bukaanada ku hawlan daaweyn is-daaweyn ah iyo qaadashada daawo is-u-qoris ah ama talooyinka asxaabta ama ogeysiisyada Remedia (waxbarida badanaaba waa la iska indhatiray, taas oo aad uga niyad jabsan). Jawaabta xun ee dhakhaatiirta takhasuska ah ayaa si aan macquul ahayn loo arkay. Tani waxay sabab u tahay isticmaalka saxda ah ee saxda ah ee alaabta daawada (macluumaadka ku saabsan Remedia 500, waxbarashadu waxay ka kooban tahay macluumaad ku filan oo ku habboon maamulka habboon ee daawada).

Analogs of daaweynta daaweynta

Wixii Remedia ah, barashada analogues ayaa tilmaamaya sidan soo socota: maaddaama daawadani ay tahay daawada antibiyootiko ee fluoroquinolone levofloxacin, waa suurtogal in la tixgeliyo dhammaan daawooyinka isku midka ah ee ka kooban halabuurka. Kuwa ka mid ah, waa in aan sheegnaa ugu horeyntii "Levofloxacin", "Zolev", "Lebed", "Levoximed" iyo kuwo kale oo badan. Wixii "Remedia" (kiniiniyaasha), barista isticmaalka isku dheelitiryada ayaa bixiya daawooyinka sida "Leflok", "Floxyum" iyo kuwo kale.

Gabagabo

Qeybta firfircoon ee Remedia waa daawada antibiyootiko ee levofloxacin. Waa daawo liddi ku ah bakteeriyada oo leh ficil fara badan oo ficil ahaan leh bakteeriyadu. Iyadoo ay sabab u tahay dhacdooyinka hooseeya ee falcelinta xun iyo la'aanta caabuqa antibiyootig ee noocyada kala duwan ee bakteeriyada, waxaa si guul leh loo isticmaalaa habka daaweynta ee Remedia. Tilmaamaha isticmaalka waxay bixiyaan macluumaad aad u faahfaahsan oo ku saabsan waxqabadka daroogada.