Alpha-fetoprotein ee xaaladaha caadiga ah iyo bahal

Alpha-fetoprotein waa wax ka soo jeedo protein kaasoo lagu soo saaro baxaan koleyga dheefta ee embriyaha waxay dhalashada ka dib - jirta marinka dheef shiidka iyo in unugyada beerka. Sida caadiga ah, waxaa ku jira jidhka ilaa 15 NG / ml.

Alpha-fetoprotein la go'aamiyo inta ay uurka leedahay si loo baadho cilladaha caloosha. Waxaa helaa qeexidda codsiga of tilmaame iyo kansarka. Alpha-fetoprotein waa oncomarker kansarka Testicular beerka. In ku saabsan 70% ka mid ah ragga la burooyinka Testicular waxaa Qolol, gaar ahaan geeddi-socodka metastasis.

Marka hore, waa walax protein ah ku dhexsameeysmo jirka ee ugxan, la yirahdo gulkroppshormon. Toddobaadkii shanaad, ilmaha caloosha ku bilaabmaa in ay soo saaraan u gaar ah. Alpha-fetoprotein ka ilaaliya ilmaha caloosha ka soo nidaamka difaaca hooyada, taas oo uu yahay wakiilka ajnabi ah.

Its fiirsashada bateen saamiga sida dhiig embriyaha iyo dhiigga hooyada. Qiimaha isitcmaalo dhimaya this lagu ogaado - at 12-16 toddobaad. At 32-34 toddobaad ee uurka gaaro heerka ugu sareeya ee Alfa-fetoprotein. caadi aadanaha caafimaad waxaa lagu gaarayaa in sannadka ugu horeeya ee nolosha.

Hababka Research weyn u saameeya qeexidda tilmaanta. aan caadi ahayn naqshada Guud aqbalay ee Alfa-fetoprotein ahaa badnaanta ee bartamaha (Itobiya). bartamaha waa tirada dhexe ee qiyamka ah amar ku fiirsashada protein ee uurka caadiga ah gudahood xilli. Sidaas darteed, mid ka mid is barbardhigi kartaa uurka Alfa-fetoprotein ee marxaladaha kala duwan, iyo sidoo kale qoral sameeyey laboratories kala duwan. Heerarka index ka 0.5 2.5 Itobiya waa caadi.

Kordhinta AFP wuxuu noqon karaa calaamad u ah:

• Burooyinka of bronkie.
• metastases beerka.
• Kansarka caloosha, xameetida, sambabada, beerka, xiidanka, naaska.
• Testicular embriyaha iyo burooyinka ugxansiduhu.

Ku meel gaar ah iyo in yar kordhay Alfa-fetoprotein ee heley soo socda:

• cirrhosis beerka,
• Chronic failure beerka,
• Khamriga joogitaanka dhaawac beerka,
• Chronic ama ba'an hepatitis viral.

tiradaasi kor u kacay inta ay uurka leedahay u muuqataa in arrimaha soo socda:

• uurka Multiple.
• Cudurka Kelyaha ee ilmaha caloosha ku.
• Sheelada xudunta in ilmaha caloosha ku.
• galleeyda beerka uurjiifka.
• Cilladaha tuubada neural (rahishizis, Anencephaly).
• Dillaacii derbiga hore ee caloosha caloosha.
• curyaanimo kale.

Si kastaba ha ahaatee, hoos u Alfa-fetoprotein ee uurka waxay muujin kartaa waxyaabaha soo socda:

• uurka Beenta ah.
• dhac koritaan.
• dhimashada uurjiifka.
• uurka gaws.
• dhicinta lama filaanka ah.
• Trisomy ee koromosoom 18 ama 21.

fiirsashada hoos Alfa-fetoprotein ayaa tilmaamaya laga yaabaa in go'aan qaldan ee muddada uurka, in uu yahay, fikrad ah ka dib dhacay.

In dumarka marxalad la joogo waa rin hoose firfircoon tilmaame of cudurada koromosoomyada uurjiifka oo heley ee uurka. Duwanaanta ka horumarinta caadiga ah uurjiifka bedeli fiirsashada caadiga ah ee walxaha protein in dhiigga hooyada. Dabcan, waa inuu jiraa ma aha oo kaliya qeexidda tilmaamahan, sida ay tahay wargelin ah. Daruuri u baahan yihiin si ay u qabtaan waxbarashada ultrasound, taas oo suurto gal ah si loo hubiyo qeexidda sax ah muddada, uurka kala duwan iyo wixii la mid ah. Sidoo kale, waxaa lagama maarmaan ah in la aqoonsado iyo hormoonnada mandheerta (gonadotorobin iyo estriol free), jidaynayey qiimayn sax ah nidaamka fetoplacental. Waxay isku dhafan oo Alfa-fetoprotein waxaa lagu qeexaa in imtixaanka xaafuun kaas oo u ogolaanaya si loo ogaado khatarta ah noocyo kala duwan oo curyaanimo in ilmaha caloosha ku.